Lenire — Bimodal Stimulation Treatment by Neuromod

My tinnitus got a lot worse about 18 months ago. All I can say is you somehow adapt over time. Don't write yourself off yet.

May well be able to cope further along the road.

Lenire seems to be causing real harm to some. Are Neuromod getting any feedback on this?
How is your reactive tinnitus? I remember your topic about nerve section, did you had any procedure on it?

Did you habituate to your tinnitus?
 
Hi all!

I just wanted to post again that my tinnitus still remains improved after using Lenire. The bad days are fewer and those are more easily manageable. Lenire didn't cure me totally but it made a life changing improvement for me. I still use it but only 30 min/day.

I'm sorry for the ones not improved or even possibly got worse. If one person got Trigeminal neuralgia, it is not sure Lenire caused it, it could have happened anyway. Many people take headache pills (paracetamol) and die of heart attacks, and that doesn't mean that paracetamol causes heart attacks. It must be proven that the risk factor for heart attacks are increased from taking paracetamol.

Trigeminal neuralgia in relation to Lenire is of course important to follow in the future. Is it only one reported case?
 
If one person got Trigeminal neuralgia, it is not sure Lenire caused it, it could have happened anyway. Many people take headache pills (paracetamol) and die of heart attacks, and that doesn't mean that paracetamol causes heart attacks. It must be proven that the risk factor for heart attacks are increased from taking paracetamol.

Trigeminal neuralgia in relation to Lenire is of course important to follow in the future. Is it only one reported case?
I believe so... on here at least.

Believe it or not, I developed chronic nerve pain on the day I was due to try Lenire. If I had developed it the day after I tried Lenire, I would of course assume that Lenire had caused it. That's how easy it is for something like that to happen. Correlation vs causation is a huge problem when it comes to health.

Congratulations on your success with the device.
 
That does not surprise me since the entire clinical definition of hearing loss is based on a 125Hz-8000Hz pure tone audiogram. It's probably safe to assume people with very high pitch tinnitus have an undocumented hearing loss.

I came across some people with tinnitus who don't have loss even on an extended audiogram, but it's a minority.

I really don't understand why this isn't studied more. Audiologists keep quoting the same stupid numbers even though when pressed they must admit the data is flawed and more research is needed. How hard would it be to let a Ph.D. candidate run a study in a tinnitus clinic? All it takes is 5 extra minutes in the audio booth.

I've seen a preliminary study suggesting that when performing an extended audiogram, the group "without hearing loss" suddenly shrinks by a lot.

What about those with hearing loss and no tinnitus?
According to Dr. De Ridder, they must have something in the brain that does not try to compensate for hearing loss by mal-adapting and introducing noise in the system.
My father and i have the same genes. He (87) has massive hearing loss on all frequencies (almost deaf) due to loud noise exposure all his life (working with machines as a carpenter without any ear protection ever). He doesn't suffer from tinnitus or hyperacusis. I have been exposed to noise all my live also (musician DIY...). But the difference probably is I was once exposed to extreme loud noise from a PA monitor and this event caused my initial tinnitus (trauma). My ears felt like they snapped (sharp pains). Maybe it is inflammation or nerve damage that causes tinnitus and hyperacusis and not necessary hair cell loss.
 
My father and i have the same genes. He (87) has massive hearing loss on all frequencies (almost deaf) due to loud noise exposure all his life (working with machines as a carpenter without any ear protection ever). He doesn't suffer from tinnitus or hyperacusis. I have been exposed to noise all my live also (musician DIY...). But the difference probably is I was once exposed to extreme loud noise from a PA monitor and this event caused my initial tinnitus (trauma). My ears felt like they snapped (sharp pains). Maybe it is inflammation or nerve damage that causes tinnitus and hyperacusis and not necessary hair cell loss.
It seems to be that the combination of hair cell and/or synapse damage *and* the resulting neuro-inflammation that causes tinnitus. I imagine if you were to hypothetically extremely gradually lose a limb over years, you would likely be much less prone to phantom limb. It seems like the neuro-inflammation from sudden loss seems to result in more maladaptive neuroplasticity as a response.
 
You write *AND* but some have no hair cell damage but still have tinnitus.
Some have (temporary) tinnitus just due to ear wax.
Someone recently posted here he got tinnitus just by pressing weight on a bench. 20 year-old, probably very healthy ears/cochlea/hair cells/synapse.

I experience very different tinnitus sounds which I think have different causes and developed in different time frames. One of them is related to hyperacusis and is somatosensoric, the other is not and completely different.
 
You write *AND* but some have no hair cell damage but still have tinnitus.
Some have (temporary) tinnitus just due to ear wax.
Someone recently posted here he got tinnitus just by pressing weight on a bench. 20 year-old, probably very healthy ears/cochlea/hair cells/synapse.

I experience very different tinnitus sounds which I think have different causes and developed in different time frames. One of them is related to hyperacusis and is somatosensoric, the other is not and completely different.
Of course. I was specifically talking about cases of cochlear damage. Sorry if that wasn't clear.
 
Anyone have any idea if Neuromod will be upgrading their core product as an evolutionary device or will they launch separate versions such as Lenire V2 for example?
I've asked them about this a couple of times over the last month or so - will they be refining the treatment protocols in light of the feedback they've received from their first wave of patients. I've never got a straight answer out of them - I think they're as in the dark about why it does or doesn't work as the rest of us.

They're not collecting any data from current patients, just anecdotal feedback, so I don't see how they could formulate any refinements.

I'm not holding out any hopes for FX-322 - it seems too science fiction at this stage - so my gaze is falling on Susan Shore for the inevitably drawn out commercialization of the UMich device.
 
It seems to be that the combination of hair cell and/or synapse damage *and* the resulting neuro-inflammation that causes tinnitus. I imagine if you were to hypothetically extremely gradually lose a limb over years, you would likely be much less prone to phantom limb. It seems like the neuro-inflammation from sudden loss seems to result in more maladaptive neuroplasticity as a response.
I've made this observation too.

Maybe that's why corticosteroids work in acute cases? Not to prevent cell death from apoptosis as presumed, but fighting inflammation and thus preventing neuroplastic changes?
 
They're not collecting any data from current patients, just anecdotal feedback
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I've made this observation too.

Maybe that's why corticosteroids work in acute cases? Not to prevent cell death from apoptosis as presumed, but fighting inflammation and thus preventing neuroplastic changes?
Partly, but steroids sometimes preserve hair cells and hearing too as evident by before and after audiograms.
 
Partly, but steroids sometimes preserve hair cells and hearing too as evident by before and after audiograms.
Yes. No doubt the audiograms recover, but wouldn't you agree that could be down to the brain "flattening out the hearing dip" by using bundles of neighbouring hair cells for off-frequency listening? I recall reading this somewhere. The audiogram recovery happens over a longer time window, like weeks and months, where hair cells would probably die or recover within 72 hours after trauma. It's hard to know for sure as we cannot look into the cochlea but I wonder if any research has been conducted post-mortem of the test subject.
 
Yes. No doubt the audiograms recover, but wouldn't you agree that could be down to the brain "flattening out the hearing dip" by using bundles of neighbouring hair cells for off-frequency listening? I recall reading this somewhere. The audiogram recovery happens over a longer time window, like weeks and months, where hair cells would probably die or recover within 72 hours after trauma. It's hard to know for sure as we cannot look into the cochlea but I wonder if any research has been conducted post-mortem of the test subject.
Inflammation can interfere with hair cell function (and eventually lead to hair cell death) after acute injury. People can actually recover their hearing in some cases if treated early/within the first two weeks. It can be across an entire hearing range (i.e. that "dip" in the case. some viral causes of SSNHL can be all frequencies in some cases) so it's not due to the brain picking up neighboring cells.
 
Or maybe they went under... :(

All hail the king, FX-322. :beeranimation:
Eh, if they can actually improve this then I'm not against it. Having FX-322 and neuromodulation as an option instead of just FX-322 works for me. The more effective ways we have to treat this monster, the better everyone will be.
 
Eh, if they can actually improve this then I'm not against it. Having FX-322 and neuromodulation as an option instead of just FX-322 works for me. The more effective ways we have to treat this monster, the better everyone will be.
I agree with you. I'm sure they will fine-tune Lenire and it will become helpful for a lot of people eventually.
 
What happened? (I haven't been following this thread.)
Lenire doesn't seem to be the "miracle" we all were hoping for.
It is more or less a bust.
Definitely not a game changer.

The hype is over and this thread will fade into obscurity - time to move on and forget about Lenire for now.
 
Very insightfully conclusive, steyrs:

Lenire still shows no indication of being available in the US (and for a cost of over $3,000.00 with such results as have been posted on here, perhaps there is no longer any reason why it should be).

It has been two years and nearly nine months since our Chicago Tribune in the Health and Wellness Section had a feature article on Susan Shore's device (with the comments that substantial testing had already been completed). Didn't she mention that testing would be completed in "early Autumn" of this year?

Well, here we are moving into September, and regarding commercialization and availability it feels as if I am waiting for the return of Hailey's Comet.

Will she come clean about the real results of this many years of testing?
Is this another convincingly theoretical venture that unfortunately yields negligible results in practice?

As I have reiterated, I recall that every external, topical treatment I attempted for my migraines was useless until the powerful drug Maxalt was introduced (that actually shrank the dilated blood vessels surrounding the brain).

Such a direct effect that can only be produced by a drug is still, I opine, what will be necessary to finally treat this.
 
Such a direct effect that can only be produced by a drug is still, I opine, what will be necessary to finally treat this.
So, the Minnesota device showed clear results, so bimodal stimulation isn't useless. There's also just recently been the results of a 5 year study where in the Netherlands I think, we they had an implant deal with tinnitus as well. It reduced it 50%. So, it can work, when done right.

Lenire's problem is they're trying to mass produce something I suspect is too individual. They need to get the timing of the shocks right, and right now, I don't think it does. Hence why some have great responses, and others don't. I believe they'll see this from their TENT studies.

In the meantime, if this private company wants to work towards a cure, I'm not going to hold it against them.
 

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