ok, so i've got another followup and i think it is positive. with the cbd/thc and the cb1 receptor, the British Journal of Pharmacology refers to "selective downregulation" of receptors, which means there are cb1 receptors all over in the brain, and as you feed the brain with cannabinoids, the receptors diminish in numbers, as a reaction to the abundance of canabinoids. however, what is observed to happen, is some parts of the brain diminish numbers of receptors more than in other parts, which means the bottom line, that it can happen that the unwanted side effects, caused by the cb1 receptors, can down regulate to a greater degree than the cb1 receptors that are responsible for the beneficial effects.
so i have been using myself as guinea pig, because the experiment is otherwise unethical, and i am aware that i may be causing permanent harm to myself, but there is a possibility i can benefit myself, based on "selective downregulation".
so that, is the background theory.
the result, is that i'm feeding myself with the same dose, approx .13g of cbd blue dream, which i have not had analyzed for the specific phenotype i happened to grow out, and commercially available 0.13 Treasure Island. my hunch is the cbd blue dream is higher in cbd than thc, because other "balanced" strains, are not working as well. Treasure Island, I know to be 17% CBD and 0.6%THC. At minimum, i am then vaping a 3:1 CBD / THC product, with the vape set at 180C. the effect of this vape, now, is to feel quite medicated, almost to the point of being narcotic, which is quite effective to get me to sleep, despite what is said about CBD keeping you awake. also, my strains are Sativa, again, supposedly uplifting and energizing, but in my case quite narcotic and makes me head to the couch.
so although the first impression with cannabis, is that it is useless, and why am i fooling myself, with prolonged use, it seems like it is doing the job for me. which is great for a medication that has a positive health effect profile, supposedly promotes neural plasticity, and promotes generation of new brain cells and promotes memory.
overall people that know me quite well, observe a noticeable improvement in my appearance/demeanor/work-stamina.
so i can't guarantee the results for everyone, but for me, i was noticing exactly what everyone else was reporting, was that cannabis was causing a tinntis spike, and the inclination was to give up, but instead i chose to hope for a selective down regulation to work in my favor, so far it seems like yes.
for example, initially i would get quite a big tinnitus spike from cannabis, gradually the spike changed in character, now i get a minimal spike with strong narcotic like sedation. i feel as if my command of my work is fine, my memory seems quite fine, and so i am actually pleasantly surprised, actually, because i was for the longest period of time very pessimistic. i was sure what i was doing would not work, so there is no placebo effect going on here. at the moment, i take 0.12mg pure CBD sativa with 0.12mg cbd/thc sativa in equal amount, and if i wake up in middle of night, which is pretty much guaranteed, i take another similar dose. so daily, i take 0.5g total cannabis, with 0.25 being thc/cbd strain, i am likely taking 10mg of actual thc and maybe 30mg cbd. cbd modulates the thc receptor, so i am not getting the non-modulated thc effect, which is increased pulse/paranoia/ etc, all the usual thc side effects, instead the cbd acts like a "protector", changes the shape of the thc receptor so it doesnt fit in so snugly, and does not activate it to the same extent if cbd was not there.
the other interesting part about cbd, is that cbd inhibits the brains own enzyme that breaks down its own endogenous cannabinoid, which means that you now have the benefit of the brains own built in cannabinoid system at play.
many of the major breakthrough in medecine come from plant world, such as anti cancer, anti biotic, general anesthetic, cardiac medication, and cannbis represents an untapped treasure trove, to quote the British Journal of Pharmacology. due to prohibition, reseach has been very limited, but we have the opportunity in my jurisdiction to access medical cannabis by prescription, including growing, and i'm kind of optimistic now that i'm on to something.
i also report that moving to new surroundings, with much less exposure to low frequency industrial rumbling noises, and traffic noise has also likely helped me out. you also need a positive attitude, and belief that you are getting better, you can get better, and you will get better. Because, simply put, you will get better. use the tools you learn on this forum. you dont' need to resort to cannabis, but if that is your choice, my experience is like everyone else here, cannabis will cause a tinnitus spike, but eventually, the amount of spike goes down, and the sedation effect that you're looking for, the anti anxiety anti depressant and pro-mood effects will help you out. only attempt this if you live in a place where this is legal, and you know for sure that you are getting pure cbd strains, and a 2:1 cbd/thc strain, and use them in equal proportion by vaping. oral ingestion of cbd is very poor, and will not work. oral ingestion of delta-9 thc goes through the liver and you get 10 hydroxy thc which is highly psychoactive, and my experience is that cannabis edible or cannabis oil is a waste of hope/effort/money/time.
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