My Posting Place

#6,332
HAHA Contrast and threefirefour hold two of the three top ratings spots on TT, along with our wonderful Glynis.
 
#6,337
Manny said:
Erm what does that mean? Or do PM ratings also count?
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no they actually removed my PM ratings or i would have been at like OVER 9000 by now.
i know my ratings are stupidly high, look how quick JohnAdam's ratings go up
 
#6,340
MPP was poppin today!

Our lord and savior @threefirefour hasn't been back in a day. He has abandon us! :(

This means we must elect a new president of MPP! The only logical way to choose one is trial by combat! :ROFL:
 
#6,341
The Battle of MPP Presidency has begun!

170112063330-turkey-lawmakers-brawl-super-tease.jpg
 
#6,343
Sorry I haven't been on i a while. My family has been dragging me places lately. I'll like everyone's comments soon.
Manny said:
I'm confused.
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It's basically a new meme. The premise is to make a meme making fun of something, and then say the meme was sponsored by a group of people with a vested interest against the thing being made fun of. So this meme is saying it's dumb to be annoyed by tinnitus, because it's sponsored by Jastreboff supporters.
 
#6,344
Bam said:
Don't despair John. I admire your tenacity and I know you genuinely want to help others and move the whole shit show on from the same old same old. Stay strong my friend and who knows one day you may be proved right.
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I'm going to despair even if we get cured. There is still going to be massive loads of suffering people everywhere, brainwashed and lied to. Children in screwed up families getting emotionally damaged. The situation here on earth is very bad. Having tinnitus is just another reality check.
 
#6,345
Ed209 said:
John, it's apples and oranges. Imatinib is a cancer drug and would have been fast-tracked due to the fact that cancer kills people. I don't make the rules, but a drug for hearingloss restoration will not be given the same treatment.
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Both AM-101 (tinnitus) and AM-111 (SSHL) received fast-track designation:
 
#6,346
Ed209 said:
This lesson was all too apparent after the drug trials for AM-101 and AUT00063 showed they were not efficacious.
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I would probably rephrase this slightly more subtly:
  • Auris Medical and Autifony Therapeutics were unable to prove efficacy with regards to AM-101 and AUT00063 (best case)
  • AM-101 and AUT00063 did not show efficacy (worst case)
The implications of the best case scenario is that there are drugs out there that may actually work but which cannot be proven to work (for various reasons: higher placebo-response, subjectivity in assessing outcome, lack of standardized patient profiles). This therefore also comes with the caveat that - unless resolved - future drug trial for tinnitus may suffer the same fate. And this "subtlety" could easily add another 10 years to the timeline of bringing a new drug to the market...
 
#6,347
JohnAdams said:
Novartis' imatinib (Gleevec) for CML -- Phase 1 trials began in June 1998, drug was approved 3 years later in May 2001 (FDA granted fast track and priority review; FDA review was a record 2.5 months)
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I would double (and triple) check that timeline (if I were you).
 
#6,348
attheedgeofscience said:
I would probably rephrase this slightly more subtly:
  • Auris Medical and Autifony Therapeutics were unable to prove efficacy with regards to AM-101 and AUT00063 (best case)
  • AM-101 and AUT00063 did not show efficacy (worst case)
The implications of the best case scenario is that there are drugs out there that may actually work but which cannot be proven to work (for various reasons: higher placebo-response, subjectivity in assessing outcome, lack of standardized patient profiles). This therefore also comes with the caveat that - unless resolved - future drug trial for tinnitus may suffer the same fate. And this "subtlety" could easily add another 10 years to the timeline of bringing a new drug to the market...
Click to expand...

That's something I didn't know. However, I stand by my point that we shouldn't be getting our hopes up until we see some clinical data. Lobbying for a new drug that we know nothing about - in humans - is futile at this stage.

I applaud the enthusiasm, but it's still not clear to me exactly what John Adams wants us all to do. We need to see what phase IIa brings up first; if it gets that far.
 
#6,349
attheedgeofscience said:
I would probably rephrase this slightly more subtly:
  • Auris Medical and Autifony Therapeutics were unable to prove efficacy with regards to AM-101 and AUT00063 (best case)
  • AM-101 and AUT00063 did not show efficacy (worst case)
The implications of the best case scenario is that there are drugs out there that may actually work but which cannot be proven to work (for various reasons: higher placebo-response, subjectivity in assessing outcome, lack of standardized patient profiles). This therefore also comes with the caveat that - unless resolved - future drug trial for tinnitus may suffer the same fate. And this "subtlety" could easily add another 10 years to the timeline of bringing a new drug to the market...
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If your tinnitus is caused by hearing loss then you dont need a tinnitus drug, you need a hearing loss drug. but yeah anything can happen. Your example is kinda stupid because fx322 isnt going to have subjective measures for efficacy. Audiograms are very objective and that's what they will use to measure efficacy. I highly doubt the placebo effect will come into play with hearing loss.
 
#6,350
#6,352
Ed209 said:
That's something I didn't know. However, I stand by my point that we shouldn't be getting our hopes up until we see some clinical data. Lobbying for a new drug that we know nothing about - in humans - is futile at this stage.

I applaud the enthusiasm, but it's still not clear to me exactly what John Adams wants us all to do. We need to see what phase IIa brings up first; if it gets that far.
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@JohnAdams I don't think he wants us to do something... what can we do as mentally ill tinnitus sufferers but donate... but maybe to get the ATA and BTA to acknowledge some advancements... not say these are cure s but to acknowledge and support their development would be a hopeful start but nooooooooooooo
 
#6,354
IAmCalifornia said:
@JohnAdams I don't think he wants us to do something... what can we do as mentally ill tinnitus sufferers but donate... but maybe to get the ATA and BTA to acknowledge some advancements... not say these are cure s but to acknowledge and support their development would be a hopeful start but nooooooooooooo
Click to expand...

FX-322 is already going through the approval process. What can we add at this stage?

If it turns out to be efficacious, and without bad side effects, then I see no problem in going all in to get this drug to the people who deserve it. Right now, however, we know nothing about it. For all we know it could make tinnitus worse.

You have to be pragmatic and look at the bigger picture.
 
#6,355
Ed209 said:
FX-322 is already going through the approval process. What can we add at this stage?

If it turns out to be efficacious, and without bad side effects, then I see no problem in going all in to get this drug to the people who deserve it. Right now, however, we know nothing about it. For all we know it could make tinnitus worse.

You have to be pragmatic and look at the bigger picture.
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Ed209, the bigger picture. They already know about the efficacy, they are doing this trial because of the FDA approval, as we know it's a process to follow. We don't have many choices, this company is already on track and they need not only support but people that will believe this will help every person with hearing issues, tinnitus and probably hyperacusis. They are a step forward.

In 2 months from now we need to get the ATA involved, we need to make a movement.
 
#6,356
Ed209 said:
FX-322 is already going through the approval process. What can we add at this stage?

If it turns out to be efficacious, and without bad side effects, then I see no problem in going all in to get this drug to the people who deserve it. Right now, however, we know nothing about it. For all we know it could make tinnitus worse.

You have to be pragmatic and look at the bigger picture.
Click to expand...

Susanna Reid posts about tinnitus. Hundreds of retweets. Only word from associations is call for support.
1000 said:
Ed209, the bigger picture. They already know about the efficacy, they are doing this trial because of the FDA approval, as we know it's a process to follow. We don't have many choices, this company is already on track and they need not only support but people that will believe this will help every person with hearing issues, tinnitus and probably hyperacusis. They are a step forward.

In 2 months from now we need to get the ATA involved, we need to make a movement.
Click to expand...

100% agree. After Susanna Reid's tweet the only response from BTA was call us for support aka crappy therapy. Not, put money towards this potentially world changing treatment.

If FX 322 is a failure, so what. As tinnitus sufferers, we're used to disappointment.

The BTA and ATA's attitude towards funds for a c t u a l treatments is depressing and angers me.
 
#6,357
I cry a lot, I know many of y'all also do.

We can't afford loosing more lives, more souls. We are all one, can't be against each other but unity.

Loosing dannyboy, kristen amber was devastating. They left an empty space. They were just like you and me. I still think of them, hope their soul's are in peace with the Lord.

We can't afford this to be a epidemic.
There's many suicidal threads and posts, many others had thought about it but are staying strong, WAITING ON FREQUENCY THERAPEUTICS. WAITING ON A MIRACLE. WAITING ON THE REAL DEAL. FX 322, right now it's the thing that brings us closer for a cure. They have the keys, they know how to cure hearing loss, they surely knows more of tinnitus than what you and me think.
 
#6,358
Just forget about the past drugs that didn't work.... That's a wasted page.
As katri was taught, forget about chapter 17, start the new chapter, 18.

Lets give fx322 a chance.

Frequency Therapeutics can bring us joy back again and can restore our hearing...nothing to lose by believing. Let's all get on same thought.
 
#6,359
1000 said:
Just forget about the past drugs that didn't work.... That's a wasted page.
As katri was taught, forget about chapter 17, start the new chapter, 18.

Lets give fx322 a chance.

Frequency Therapeutics can bring us joy back again and can restore our hearing...nothing to lose by believing. Let's all get on same thought.
Click to expand...
Sorry not interested before they announce the results of their first trial.

Blind faith is dangerous. People who believe in God even more dangerous.
 
#6,360
annV said:
Sorry not interested before they announce the results of their first trial.

Blind faith is dangerous. People who believe in God even more dangerous.
Click to expand...
If you don't believe in God, or if considered yourself an atheist, it's your own choice of living. God still loves you. God is real.
 

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