N-Acetylcysteine (NAC)

[orbiter12]

Does anyone know if this powder form
http://www.bulkpowders.co.uk/n-acetyl-l-cysteine-nac.html?gclid=CPiQ7KqR6NMCFUqx7QodSGcKtQ

is this the same as the capsules? I can swallow the capsules

 

[Iliasp]

I use these

 

[Christian78]

I use these:
http://www.jarrow.com/product/323/N-A-C_Sustain

1/3 fast realease, 2/3 slow release

 

[Christian78]

Hey @shasta0863 I don't want to start a baseless conspiracy theory here but I am also shocked enough by what you reported and how very exactly it aligns with my recent experience that I thought I should post. I have had T for over 12 years now and taken NAC after every episode of noise exposure with a "well it couldn't hurt" attitude. The dosage I'd take was actually quite high, typically 2400mg-3g/day for 4-5 days following the episode. Maybe in retrospect this was dangerous but I've also done it for many, many years without issue.

At the very end of October 2016, though, after going to a concert (at which I actually wore earplugs and don't think noise exposure was really very dramatic), I did this regimen, and 2 or 3 days into it my tinnitus in a moment became much louder and now sounds exactly as you are describing. Exactly like "electrical misfiring going haywire, going up and down and up and down" in my left ear. I have been describing it as a "swirling" but your description is dead on. Previously for me it was a constant tone, much quieter.

I still hear the old constant tone but now have this new very, very loud, very distracting electronic type swirling going on on top of it. I would say the impact on my quality of life of this new tone is a multiple of the old T I'd lived with for 12 years, mostly because the constant fluctuation in volume makes it disrupt my hearing of outside sounds in a way that is much harder to ignore. I've been checked out for inflammation, tumor etc (MRI and carotid ultrasound) by my ENT. I'm seeing a neurologist monday. I'm wondering if a bad batch of NAC floating somehow had something to do with this.

The NAC I was taking when this happened was "NOW Foods" brand, purchased from Amazon on October 9, 2016.

Again I've taken NAC for years without issue. I'm wondering if by some chance this is the brand/batch you were taking?

To be honest concert that loud even with earplugs of -20dB is still loud goes over bones and other ways. People think ear plugs protect, while they do ear canal partially but not hearing. They are meant as supplement on lower noises like lawn mower...

 

[Christian78]

I've done 2 separate 60 day experiments with NAC and it makes my T much louder and annoying.

I also had impression nac got my t up

 

[JasonP]

I found some interesting information on NAC. If you study up on neurons it might make some sense. Apparently, it can help to restore a glutamate balance to neurons after cocaine use. Before reading, just remember that glutamate is essential to the function of the body, but when it gets too low or too high things can get bad.

Here is an article on one of theories on how it works:

Source:
https://www.nature.com/nrn/journal/v10/n8/box/nrn2515_BX3.html


This is information on the cysteine/glutamate transporter:

https://en.wikipedia.org/wiki/SLC7A11#Regulation

NAC affect on glutamate before and after:

Source:
https://nootropix.com/nootropics-drug-abuse-addiction/

From what I hear, the optimum dosage of NAC is important while taking it. If it works, that's great, but too much NAC or too little can cause problems. I don't quite understand how the restoration of the synaptic terminals occurs because of NAC. It seems there is less glutamate and less AMPA and NMDA receptors after NAC restoration. That definately sounds good to prevent overexcitability of the cell if there was too much there. If anyone can explain how this works, please let me know.

 

[JasonP]

I found some interesting information on NAC. If you study up on neurons it might make some sense. Apparently, it can help to restore a glutamate balance to neurons after cocaine use. Before reading, just remember that glutamate is essential to the function of the body, but when it gets too low or too high things can get bad.

Here is an article on one of theories on how it works:

View attachment 13221


Source:
https://www.nature.com/nrn/journal/v10/n8/box/nrn2515_BX3.html


This is information on the cysteine/glutamate transporter:

https://en.wikipedia.org/wiki/SLC7A11#Regulation

NAC affect on glutamate before and after:

View attachment 13222


Source:
https://nootropix.com/nootropics-drug-abuse-addiction/

From what I hear, the optimum dosage of NAC is important while taking it. If it works, that's great, but too much NAC or too little can cause problems. I don't quite understand how the restoration of the synaptic terminals occurs because of NAC. It seems there is less glutamate and less AMPA and NMDA receptors after NAC restoration. That definately sounds good to prevent overexcitability of the cell if there was too much there. If anyone can explain how this works, please let me know.

I may have found some information on how that last part works and maybe be able to answer my own question ...

"Cysteine assists in the regulation of neuronal intra- and extracellular exchange of glutamate through the cystine–glutamate antiporter. Whereas this antiporter is ubiquitous throughout all cell types, in the brain it is preferentially located on glial cells.25 The dimer, cystine, is taken up by astrocytes and exchanged for glutamate, which is released into the extracellular space. This free glutamate appears to stimulate inhibitory metabotropic glutamate receptors on glutamatergic nerve terminals and thereby reduce the synaptic release of glutamate.26Given that relation, the amount of cysteine in the system as well as the feedback via GSH production by neurons may directly regulate the amount of glutamate present in the extracellular space. Furthermore, GSH itself has been shown to potentiate brain N-methyl-d-aspartate receptor response to glutamate in rats."

Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/

Also, here is some information I found on the MGluR2, MGluR3, and MGluR5 receptors which are shows in the picture I posted previously:

https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor

 

[EatMoTacos]

I think too much NAC is bad... since I take daily NAC, I keep it around 600mg to 1200mg.

I have had no change with my T, since I been on NAC. I am though just taking a vitamin B complete plus C (they have almost the same ingredients as a bottle of lipo).

 

[teacher34]

Yes, I agree that a consistent yet moderate dosage is likely the best way to go with NAC. I also agree with a prior poster that it's primary value is preventative rather than curative.

 

[Ecip]

Finally, melatonin (3 mg daily) limited subjective tinnitus in patients.

So, would you take 1 mg throughout the day or 3mg all at once at night before bed? lol.. i've never taken more than 1mg, and never consecutively.

 

[jer]

So what do you guys consider to be the right daily dosage for NAC to be preventative, without falling into the risk of out tinnitus possibly becoming more obtrusive? What is that safe dosage?

 

[Ecip]

So what do you guys consider to be the right daily dosage for NAC to be preventative, without falling into the risk of out tinnitus possibly becoming more obtrusive? What is that safe dosage?

I do 1000 mg per day.
If I get exposed to something really loud and it worries me, I'll do two doses of 2000 mg, and then back to 1000 per day.

 

[jer]

What brand do you use? Any links? I have some trouble swallowing large pills, so hopefully something small!

 

[IvanRus]

Guys, I ordered from the US acetylcysteine company doctor's best detox regulators 60 capsules. Today he pissed me. In together with the capsules there were two odor absorbers. But still, the smell from the capsules is very unpleasant, chemical. Who faced this? To accept it? I'm afraid...
https://www.iherb.com/pr/doctor-s-best-best-nac-detox-regulators-60-veggie-caps/41653

 

[Lex]

But still, the smell from the capsules is very unpleasant, chemical.

NAC does smell like rotten eggs.

 

[JasonP]

I believe it is also supposed to be taken on an empty stomach and with vitamin C.

 

[Fangen]

I notice that my stomach hurts and yesterday I got a fever from taking NAC. As I am going on a flight tomorrow I have taken 1200 mg of NAC in one go. Maybe I need to take 600 mg at difference times during the day? Have anybody else gotten side effects from NAC?

 

[CaRd]

Guys, I am ordering NAC, because I can see much benefits when I take it. Doctors here prescribe it as medicament for lungs cleaning, but it is too expensive and has fillers. Basically 600mg powder is like 1$ or a bit less ... I have problems with my lungs (asthma in regress), so this thing is making wonders. It even eases my tinnitus after a few days of using it.

So now I am ordering the pure stuff from iHerb and I am a bit confused between three products.

Two of them are Jarrow NAC (sustained and not sustained) and the other is Thorne Research, Cysteplus. The latter one is more expensive, but as I understand Thorne is a top-quality, pharmaceutical grade company. It has fewer fillers, no magnesium stearate(but has Hypromellose), and it is a capsule (which I think is better than tablet).

Yep ... I am overthinking it

But has anyone tried any of these products? Any recommendations?

 

[JasonP]

I notice that my stomach hurts and yesterday I got a fever from taking NAC. As I am going on a flight tomorrow I have taken 1200 mg of NAC in one go. Maybe I need to take 600 mg at difference times during the day? Have anybody else gotten side effects from NAC?

Guys, I am ordering NAC, because I can see much benefits when I take it. Doctors here prescribe it as medicament for lungs cleaning, but it is too expensive and has fillers. Basically 600mg powder is like 1$ or a bit less ... I have problems with my lungs (asthma in regress), so this thing is making wonders. It even eases my tinnitus after a few days of using it.

So now I am ordering the pure stuff from iHerb and I am a bit confused between three products.

Two of them are Jarrow NAC (sustained and not sustained) and the other is Thorne Research, Cysteplus. The latter one is more expensive, but as I understand Thorne is a top-quality, pharmaceutical grade company. It has fewer fillers, no magnesium stearate(but has Hypromellose), and it is a capsule (which I think is better than tablet).

Yep ... I am overthinking it

But has anyone tried any of these products? Any recommendations?

What do you guys think about Mucomyst? I just saw that it was basically acetylcysteine (or NAC as I understand it) which people took with an inhaler. Sometimes I wonder if it would work a little differently or faster. I have never tried it.

This website I found says that NAC taken orally will not work for respiratory diseases but inhaled NAC will.

Has anyone else on this board tried it? Feedback would be great. Thanks

http://www.clintwoodpharmacy.com/n-acetyl-cysteine.htm

 

[Melike]

Guys, I am ordering NAC, because I can see much benefits when I take it. Doctors here prescribe it as medicament for lungs cleaning, but it is too expensive and has fillers. Basically 600mg powder is like 1$ or a bit less ... I have problems with my lungs (asthma in regress), so this thing is making wonders. It even eases my tinnitus after a few days of using it.

So now I am ordering the pure stuff from iHerb and I am a bit confused between three products.

Two of them are Jarrow NAC (sustained and not sustained) and the other is Thorne Research, Cysteplus. The latter one is more expensive, but as I understand Thorne is a top-quality, pharmaceutical grade company. It has fewer fillers, no magnesium stearate(but has Hypromellose), and it is a capsule (which I think is better than tablet).

Yep ... I am overthinking it

But has anyone tried any of these products? Any recommendations?

hey buddy

Where will you order it from? It is extremely hard to find NAC in capsule form here. Only the effervescent ones that are prescribed for phlegm and I am not sure if they are the same / have the same benefits.

 

[Rubenslash]

hey buddy

Where will you order it from? It is extremely hard to find NAC in capsule form here. Only the effervescent ones that are prescribed for phlegm and I am not sure if they are the same / have the same benefits.

Iherb.com

 

[Melike]

Iherb.com

Thanks ! It seems like their shipping to TR is faster and cheaper compared to other e-retailers. Now I wonder if it goes through the customs successfully....


EDIT : oh...I haven't realized there were links embedded in @CaRd's post...Now I feel stupid lol.

 

[CaRd]

What do you guys think about Mucomyst? I just saw that it was basically acetylcysteine (or NAC as I understand it) which people took with an inhaler. Sometimes I wonder if it would work a little differently or faster. I have never tried it.

This website I found says that NAC taken orally will not work for respiratory diseases but inhaled NAC will.

Has anyone else on this board tried it? Feedback would be great. Thanks

http://www.clintwoodpharmacy.com/n-acetyl-cysteine.htm

NAC works really well for me when i have lungs problems. I start caughing out the bad stuff in my lungs after only a few days of using it. I take it as a powder.

hey buddy

Where will you order it from? It is extremely hard to find NAC in capsule form here. Only the effervescent ones that are prescribed for phlegm and I am not sure if they are the same / have the same benefits.

Hey Melike! Sorry for answering so late ... Been bussy with other things. Did you find what you are looking for? I still have not ordered NAC, but i am about to do it as the cold days are starting. I cut off most of my supplements after doing some blood-tests, so now i will be only taking NAC and Magnesium Citrate(both from Thorne).

 

[Chaz]

NAC gives me the worst gas.
Anyone else experience this haha? I could clear out a room if I wanted to.

 

[IvanRus]

Is it true that n acetylcysteine (NAC) has otoprotective (protective properties for the ear)? And it is recommended to use it as a treatment and prevention after a brief exposure to loud noise? Are there any scientific justifications? What about melatonin? Thank you

Who takes NAC, tell me how does it affect your tinnitus? Does not it increase it? What average dosage do you take, which is the maximum? Whether it is normal to accept on 1800 mg? Is NAC not ototoxic?

 

[IvanRus]

Hi @valeri:

For what it's worth, I take a low dose (7.5mg) of an antidepressant (Remeron) nightly and my doctor said that taking 600mg/day of NAC is fine. But as @jazz advises, discuss with your doctor.

You might be surprised: when I brought up NAC with my doctor, he was well acquainted as it is being touted as a wonder-drug in various medical circles.

-Golly

Tell or say, whether it is possible to 5qk3 n-acetylcysteine and antidepressant SSRI (escitalopram) simultaneously?

I take NAC 1200 mg (2 capsules) a day with an antidepressant. Just someone said that, NAC itself increases serotonin. And too much of it is dangerous.

 

[IvanRus]

I took 2000 mgs today and regularly take 1500 or 1000. Totally safe for most.

Tell or say, whether it is possible to accept n acetylcystiene and atidepressant SSRI (escitalopram) simultaneously? I take NAC 1200 mg (2 capsules) a day with an antidepressant. Just someone said that, NAC itself increases serotonin. And too much of it is dangerous. Did you take them together, this did not increase your noise?

 

[TheDanishGirl]

I have bought some NAC in powder form and took some yesterday and today, because I was going to a restaurant and a bar (with moderate music) it taste absolutely awful, but oh well.....if it works. I took the recommended 700 mg.

Can it cause T to spike?

 

[TheDanishGirl]

I don't think I will take it every day, just when and if I get exposed to some loud noise.

 

[TheDanishGirl]

I am thinking of upping my intake of NAC. The past 2-3 weeks I have taken about 800-900 mg. NAC about 3-4 times a week and now my hyperacusis has diminished to very little.

I am thinking of starting taking it on a daily basis, about 1000 mg, to see if it can help better on my tinnitus, BUT I am quite afraid of the hightened risk of kidney stones.

Do any of you know if I can do anything to prevent kidney stones.