Neuroinflammation Mediates Noise-Induced Synaptic Imbalance and Tinnitus in Rodent Models

#125
OK, I googled it:

"testing if the mice can detect a short gap in a constant, low-level background noise that happens just before a loud noise. If the mouse can hear it, then over time, it learns that the gap means there's about to be a loud noise, so they don't jump as much when it happens. But if the mouse has tinnitus, that is, if it's constantly hearing a ringing in its ears, then it won't hear the gap warning it about the noise, so they jump just as much the tenth time it happens as they did the first time. "
 
#127
JohnAdams said:
Well it stopped thinning but I'm cautiously keeping an eye on it.
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I don't believe that the thinning can just stop by itself. The thinning process can be very slow, but keep in mind that Proscar doesn't really cause one to regain the lost hair. Proscar allows you to slow down the thinning. Ideally, for about 10 years or so, you will get to mostly keep the amount of hair you have had when you began taking Proscar. So if this is important to you, and you are ok with the possible side effects of Proscar, it is better to begin taking it as soon as possible.
 
#128
Bill Bauer said:
I don't believe that the thinning can just stop by itself. The thinning process can be very slow, but keep in mind that Proscar doesn't really cause one to regain the lost hair. Proscar allows you to slow down the thinning. Ideally, for about 10 years or so, you will get to mostly keep the amount of hair you have had when you began taking Proscar. So if this is important to you, and you are ok with the possible side effects of Proscar, it is better to begin taking it as soon as possible.
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Yeah, I know, my ol' pal has been on it since he was 20. I don't think my hair thinning was natural. I think it was from eating like 12 curcumin capsules every day.
 
#129
Here's a link from a local radio station where it seems they got an interview with the University of Arizona's lead researcher on the tinnitus neuroinflammation research Dr. Shaowen Bao. They added a few seconds of it on the link.

https://kjzz.org/content/1132831/ua-rodent-study-identifies-possible-tinnitus-treatment-target

The station said that Dr. Bao cautioned it is new research, and if human trials will happen, it would be "years in the future".

Let's hope by years they mean only like 2.
 
#133
Erik11 said:
Where the hell do I get this pill? What kind of ethics do these companies have, here we suffer in pains and have to W.A.I.T
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It's not a company it's the University of Arizona. Dr. Shaowen Bao is the lead researcher and unfortunately he doesn't seem to be in a hurry to speed up his work, but I agree he really should be all over this if he has found the actual cure. It would be moronic to find the cure to something then not do anything with it.
 
#134
I'm new to this forum. Would this work for drug induced tinnitus? I'm a bit leery of drugs at this point.

Also, how do they know when mice have and don't have tinnitus? They can't ask them. Serious question. Is there a method?
 
#137
Bill Bauer said:
Take Proscar - problem solved.
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I had to google what proscar is. Propecia, aka finasteride.

I used to take it through the gray market because I was too embarrassed to try to get a prescription. It probably helped slow my hair loss. I stopped taking it once I found out about the potential sexual side-effects. I've been off it long enough and lost enough hair since then that I'd have to get back on it ASAP if it were to have any benefit. You have to understand that people pushing 50 like me tend to develop ED problems all on their own so it's something I'm concerned about.
 
#140
Candy said:
Wow so this contradicts the limbic system theory then? Can someone explain if it's a piece of the puzzle or a different theory?

What about intermittent tinnitus? Please let this be true please.
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In my opinion, the limbic system theory does not hold up when you really dig into it. It *may* play a role in the annoyance to the sounds, but the chances that it serves as a route cause seems unlikely.

This would likely be a different theory. However, one could tie the two together if they were really motivated to. For instance, it could be the inflammatory process that gets the limbic system all hot/bothered. But again, this seems unlikely to me.
 
#141
ChrisBoyMonkey said:
They did not specify in article. The actual journal on PLOS may have that information.

To be honest from what I know of psychology, other people who studied it more than I did, and from the research I have read into, I don't feel like the limbic system theory holds its weight. It could be a contributor, but it seems unlikely to be a root cause.

From what I've seen, most studies seem to show that the changes to the limbic system and other parts of the brain come after tinnitus onset.
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Exactly Chris. As a neuroscientist who studies the limbic system, this is my feeling exactly.
 
#142
ChrisBoyMonkey said:
From what I've seen, most studies seem to show that the changes to the limbic system and other parts of the brain come after tinnitus onset.
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I think the thought is that the limbic response may contribute to the chronic nature of tinnitus, rather than its onset. And so it could technically come after tinnitus onset and still be a "cause" of long-term, chronic tinnitus. In other words, if it wasn't for the limbic response, the tinnitus percept would disappear before it became chronic.

That said, I still don't buy it. The limbic response seems far more likely to me to be reactionary, rather than causal. In fact, that goes for most of the brain responses that researchers are finding. The big thing these days is to say that so many parts of the brain are involved, and that tinnitus is thus far more complicated than ever imagined. But this seems a bit straw-man to me. Far more likely, there's a root cause somewhere that hasn't yet been identified, and all these other brain regions - emotion regions and attention regions and memory regions - are all trying to deal with the fact that there's this annoying sound present.
 
#143
MattS said:
I think the thought is that the limbic response may contribute to the chronic nature of tinnitus, rather than its onset. And so it could technically come after tinnitus onset and still be a "cause" of long-term, chronic tinnitus. In other words, if it wasn't for the limbic response, the tinnitus percept would disappear before it became chronic.

That said, I still don't buy it. The limbic response seems far more likely to me to be reactionary, rather than causal. In fact, that goes for most of the brain responses that researchers are finding. The big thing these days is to say that so many parts of the brain are involved, and that tinnitus is thus far more complicated than ever imagined. But this seems a bit straw-man to me. Far more likely, there's a root cause somewhere that hasn't yet been identified, and all these other brain regions - emotion regions and attention regions and memory regions - are all trying to deal with the fact that there's this annoying sound present.
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That's exactly how I feel too. It makes much more sense, and also falls more with the TNF-alpha inflammation in the auditory center and hyperactive fusiform cells in the dorsal cochlear nucleus theories.
 
#144
If this ever does become "The Cure" then I hope we only have to take it for a short duration.

It's also made me ponder what would happen if you stayed on curcumin for years, if that would heal the tinnitus away.
 
#147
Hi all -

In case you all didn't see, that the VA is starting a clinical trial with Enbrel (a TNF inhibitor for arthritis, inflammation-related diseases) as a means of tinnitus suppression.

https://www.clinicaltrials.gov/ct2/show/NCT04066348

Would be great to hear from any forum members that may have taken Enbrel, Humira, Remicade, or any other TNF-inhibitors as to whether it had any impact on their tinnitus.
 
#148
Heinrich_S7 said:
If this ever does become "The Cure" then I hope we only have to take it for a short duration.

It's also made me ponder what would happen if you stayed on curcumin for years, if that would heal the tinnitus away.
Click to expand...
As far as I can tell turmeric/curcumin only offer a temporary suppression.
 
#149
Bears mentioning that Shaowen Bao (The U of Arizona Professor who is deep into TNF's link to Tinnitus) is one of the Principal investigators on the upcoming VA trial of Enbrel for Tinnitus.
 
#150
LostOutWest said:
Bears mentioning that Shaowen Bao (The U of Arizona Professor who is deep into TNF's link to Tinnitus) is one of the Principal investigators on the upcoming VA trial of Enbrel for Tinnitus.
Click to expand...
Makes sense. I remember hearing of some cases similar to this before, where some people would take a pill for something else and then this lowered.

It also would be faster to approve something already on the market for this instead of making a whole new pill and all the clinical trials. They still should work on a pill specifically for this too though, in case the ones already out aren't of much help.
 

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