New University of Michigan Tinnitus Discovery — Signal Timing

[Manny]

This person is still waiting to be called to start in the trial...

Who is "this person"?

 

[1000]

A participant.

 

[1000]

The trial will be divided in 2 parts, they will assign real devices and fake devices in both parts of the trial... During the 6 months.

 

[MickV]

It isn't meant to repair or fix that. It is meant to stop the cells from sending the signal to the brain which creates the sounds.

But you have to fix the damaged area in order to silence it.

 

[ee9892]

But you have to fix the damaged area in order to silence it.

I think you're confusing a treatment with a cure.

 

[Ecip]

The tinnitus came back for those people that reported to have felt relief - meaning - it does not work.

That's scientifically quite pessimistic, lol. But, according to everything, it does work.

 

[Ecip]

But you have to fix the damaged area in order to silence it.

According to the research and the trials, you don't. Again, repairing/regrowing hair cells does not mean a remission of tinnitus symptoms.

 

[Ecip]

No duh. But it is the absolute best hypothesis that if your tinnitus came from hearing loss then reversing hearing loss will reverse tinnitus. Theres also 16 people that have been give the drug and they will know very soon. You have to be completely insane not to be interested in the outcome here.

That's pure speculation, at best.

Which drug?

 

[kelpiemsp]

I think you're confusing a treatment with a cure.

No they are confused about tinnitus. Tinnitus is in the brain. Ear damage can lead to Tinnitus but unless it's pulsatile in nature, the issue is a maladaptive plastic response in your brain. No need at all to mess with the ear.

 

[Soren]

We just don`t know enough about tinnitus to say that it is fully in the brain, the ear or both. There is evidence that points to some of these. Like getting a cochlear implant or hearing aids will help with tinnitus, or that bimodulation helps with tinnitus.

Hopefully FX-322 will shed some light on the ear part in tinnitus.

 

[kelpiemsp]

We just don`t know enough about tinnitus to say that it is fully in the brain, the ear or both. There is evidence that points to some of these. Like getting a cochlear implant or hearing aids will help with tinnitus, or that bimodulation helps with tinnitus.

Hopefully FX-322 will shed some light on the ear part in tinnitus.

I think the research is pretty clear. There is a reason every single tinnitus therapy focuses on the brain and drugs like Fx-322 aren't even marketed towards tinnitus at all.

 

[Manny]

I think the research is pretty clear. There is a reason every single tinnitus therapy focuses on the brain and drugs like Fx-322 aren't even marketed towards tinnitus at all.

It seems widely accepted that many cases of tinnitus are a result of reduced auditory stimuli to the brain due an aural hearing loss.
As such, would it not seem reasonable that restoring hearing would reduce tinnitus?

 

[MickV]

It seems widely accepted that many cases of tinnitus are a result of reduced auditory stimuli to the brain due an aural hearing loss.
As such, would it not seem reasonable that restoring hearing would reduce tinnitus?

That's exactly what I was saying!!! There you go. You need to fix the nerve/hair cells in order to fix tinnitus!

That is why this machine will not work!

 

[Jack Straw]

That's exactly what I was saying!!! There you go. You need to fix the nerve/hair cells in order to fix tinnitus!

That is why this machine will not work!

This machine isn't supposed to cure tinnitus. It is supposed to reduce the symptom aka ringing. Just like insulin doesn't cure diabetes, but it helps keep it under control.

 

[ee9892]

This machine isn't supposed to cure tinnitus. It is supposed to reduce the symptom aka ringing. Just like insulin doesn't cure diabetes, but it helps keep it under control.

Exactly.

Viagra doesnt make your dick work the rest of your life. But it helps when used.

 

[katri]

Exactly.

Viagra doesnt make your dick work the rest of your life. But it helps when used.

Starting to think I don't understand viagra as much as I thought I did.

 

[MickV]

This machine isn't supposed to cure tinnitus. It is supposed to reduce the symptom aka ringing. Just like insulin doesn't cure diabetes, but it helps keep it under control.

So are you saying if you reduce your tinnitus then maybe over time it can get cured on its own? Maybe?

 

[Petronius]

It seems widely accepted that many cases of tinnitus are a result of reduced auditory stimuli to the brain due an aural hearing loss.
As such, would it not seem reasonable that restoring hearing would reduce tinnitus?

Tinnitus is not a result of hearing loss, otherwise almost everyone would have tinnitus.

 

[Silvio Sabo]

I think the research is pretty clear. There is a reason every single tinnitus therapy focuses on the brain and drugs like Fx-322 aren't even marketed towards tinnitus at all.

If damage to the inner ear drives brain plasticity to produce tinnitus. Wouldn't repairing the damage drive the same brain plasticity mechanism to revert back to normal?

As far as I understand it our brain fills in for gaps in neural input. The same thing happens in our vision and the so called blind spot and people that have lost limbs that experience phantom pain (which tinnitus has been compared to).

I've also read about people that have had their tinnitus resolve completely after cochlear implants. If it were only a brain problem, that shouldn't happen.

So if we fill in the gap wouldn't the brain "go back to normal"?

The reason why FX-322 isn't marketed towards tinnitus is, in my own belief at least, because hearing loss can easily be quantifiably measured. Tinnitus is a bit tricky in that reagard.

 

[annV]

So if we fill in the gap wouldn't the brain "go back to normal"?

That makes sense but is it possible if you have had tinnitus for many years that the tinnitus gets permanently entrenched in the brain and won't go away even if hearing organ is made to function impeccably?

 

[grate_biff]

That makes sense but is it possible if you have had tinnitus for many years that the tinnitus gets permanently entrenched in the brain and won't go away even if hearing organ is made to function impeccably?

That would certainly go against plasticity, wouldn´t you agree?

You are really good at planting seeds of doubt @annV.

 

[Silvio Sabo]

That makes sense but is it possible if you have had tinnitus for many years that the tinnitus gets permanently entrenched in the brain and won't go away even if hearing organ is made to function impeccably?

I was tinnitus free for the first 22 years of my life. Why hasn't that been permanently entrenched in my brain?

 

[Jack Straw]

Tinnitus is not a result of hearing loss, otherwise almost everyone would have tinnitus.

There is no scientific fact to back this statement up. Tinnitus can be caused by many things including hearing loss. Hearing loss can cause tinnitus because there is less noise coming in externally, increasing the perception of tinnitus, or because the brain is deprived of a stimulus and creates the sound in the brain itself.

Many people have hearing loss with no tinnitus, many people do. It has been shown that certain people's brains have the ability to "turn off" these phantom sounds, while others don't. For some reason those of us with tinnitus for some reason don't have the mechanism in the brain to turn off those sounds. Just like some people who lost limbs can feel phantom pain and feelin while others can not.

 

[Petronius]

There is no scientific fact to back this statement up. Tinnitus can be caused by many things including hearing loss. Hearing loss can cause tinnitus because there is less noise coming in externally, increasing the perception of tinnitus, or because the brain is deprived of a stimulus and creates the sound in the brain itself.

Many people have hearing loss with no tinnitus, many people do. It has been shown that certain people's brains have the ability to "turn off" these phantom sounds, while others don't. For some reason those of us with tinnitus for some reason don't have the mechanism in the brain to turn off those sounds. Just like some people who lost limbs can feel phantom pain and feelin while others can not.

There is also no scientific explanation that T is generated by the brain because of deprivation of stimulus and hearing loss.

 

[Jack Straw]

There is also no scientific explanation that T is generated by the brain because of deprivation of stimulus and hearing loss.

There is a lot more evidence and research pointing toward hearing loss and lack of stimulus than pointing away from it.....

 

[Petronius]

There is a lot more evidence and research pointing toward hearing loss and lack of stimulus than pointing away from it.....

There is scientific evidence that some people's brains can switch off T? I wonder where can I find that evidence.

 

[Jack Straw]

There is scientific evidence that some people's brains can switch off T? I wonder where can I find that evidence.

 

[Ecip]

Tinnitus is not a result of hearing loss, otherwise almost everyone would have tinnitus.

Well, actually... lol

 

[kelpiemsp]

If damage to the inner ear drives brain plasticity to produce tinnitus. Wouldn't repairing the damage drive the same brain plasticity mechanism to revert back to normal?

As far as I understand it our brain fills in for gaps in neural input. The same thing happens in our vision and the so called blind spot and people that have lost limbs that experience phantom pain (which tinnitus has been compared to).

I've also read about people that have had their tinnitus resolve completely after cochlear implants. If it were only a brain problem, that shouldn't happen.

So if we fill in the gap wouldn't the brain "go back to normal"?

The reason why FX-322 isn't marketed towards tinnitus is, in my own belief at least, because hearing loss can easily be quantifiably measured. Tinnitus is a bit tricky in that reagard.

That's the hope. But so far it's proving easier to drive plasticity.

 

[Bart]

"We're definitely encouraged by these results, but we need to optimize the length of treatments, identify which subgroups of patients may benefit most, and determine if this approach works in patients who have nonsomatic forms of the condition that can't be modulated by head and neck maneuvers," Shore said.

Seems to only work for some forms of tinnitus , and there are alot of ifs and maybes .

Anyway, let's hope this leads to something, looks promising at least .