Prof. Thanos Tzounopoulos Receives $2 Million Grant

#61
Daniel Lion said:
Hi bro, I gave you a star for your awesome uplifting message.

One issue, not a biggy, but I got to say it.

The DoD wastes money all the time and gets ripped off all the time by corrupt subcontractors and insiders. I want a cure, and think this bloke in Pittsburgh is a morally sound person. The DoD, as I recall, sponsored Levo? If I am wring, I stand corrected, but I don't have much faith in them. They may have good intentions, like the VA, but perhaps the bureaucratic system is just too big...

I am with you bro, just raising a question mark over the DoD.
Hope your tinnitus is mellowing, mine is a consistent thorn in my ass.
Click to expand...
It's all good. Thankfully mine is mellowing! Still not as mellow as before the worsening but it just might be getting there. I'm sorry about yours being the same.

As having been a member of the DoD myself by being a U.S. Army soldier, the spending inside is not wasteful, it's just that there's a huge budget and veterans are suffering. What they're doing is giving them the least they can do, which is giving them what's available.
 
#62
ChrisBoyMonkey said:
It's all good. Thankfully mine is mellowing! Still not as mellow as before the worsening but it just might be getting there. I'm sorry about yours being the same.

As having been a member of the DoD myself by being a U.S. Army soldier, the spending inside is not wasteful, it's just that there's a huge budget and veterans are suffering. What they're doing is giving them the least they can do, which is giving them what's available.
Click to expand...
Glad your tinnitus is mellowing, as far as the DoD goes, agree to disagree... in peace.
 
#63
ChrisBoyMonkey said:
It's all good. Thankfully mine is mellowing! Still not as mellow as before the worsening but it just might be getting there. I'm sorry about yours being the same.

As having been a member of the DoD myself by being a U.S. Army soldier, the spending inside is not wasteful, it's just that there's a huge budget and veterans are suffering. What they're doing is giving them the least they can do, which is giving them what's available.
Click to expand...
Can't talk about the US, but in the UK the MOD is very wasteful. Figures as high as £6 billion are often wasted, and you've got to remember the UK'd defence budget is way lower than US's.
 
#64
For those who don't know, the Hough Ear Institute also received funding from the DoD. They're also working on nerve regeneration for hearing loss and tinnitus. Check them out.
 
#65
Rb86 said:
For those who don't know, the Hough Ear Institute also received funding from the DoD. They're also working on nerve regeneration for hearing loss and tinnitus. Check them out.
Click to expand...
Have been to Hough. Was very impressed by their professionalism and concern.
 
#66
FGG said:
Have been to Hough. Was very impressed by their professionalism and concern.
Click to expand...
I just donated 100 dollars to them. Really hope they can succeed quickly. They're the most promising and most responsive group I've encountered to date. Impressive research team as well.
 
#67
Hi there,

We will be interviewing Prof. Tzounopoulos soon for the Tinnitus Talk Podcast!

Cheers,
Hazel
 
#68
smapti said:
Thought I would chime in on this one and show you a reply to a recent e-mail from Dr.
Tzounopoulos. As far as I see it, he is our greatest hope. Everything else is just so...well...1972.

Hello -

I know you get a lot of questions about this, so I'll be brief:

(1) Will RL-81 have a clinical trial? If so, when will it start?

Yes. We are currently performing preclinical studies (toxicity, etc)


(2) What is the possibility it will work for tinnitus sufferers?

Do not know for sure, but I am optimistic based on our research so far


(3) If it works, when do you project it could be on the market? 5 years? 10 years? Not in our lifetime?

Hard to predict the future – I do not plan to leave the planet before we have FDA approved medication for tinnitus
Click to expand...

Do you think it's worth reaching out to Dr. Tzounopoulos for an update? I was going to try him on Twitter until I saw your post. Is the drug he is using the same as Keppra/Levetiracetam but modified?
 
#69
vttbx said:
Do you think it's worth reaching out to Dr. Tzounopoulos for an update? I was going to try him on Twitter until I saw your post. Is the drug he is using the same as Keppra/Levetiracetam but modified?
Click to expand...
It's a remake of Trobalt / Retigabine.

An update would be nice, last I heard from him he just said it's still in preclinical trials and the clinical trials are next.
 
#70
vttbx said:
Do you think it's worth reaching out to Dr. Tzounopoulos for an update? I was going to try him on Twitter until I saw your post. Is the drug he is using the same as Keppra/Levetiracetam but modified?
Click to expand...
Always worth it. Nothing to lose. Everything to gain.
 
#71
vttbx said:
Do you think it's worth reaching out to Dr. Tzounopoulos for an update? I was going to try him on Twitter until I saw your post. Is the drug he is using the same as Keppra/Levetiracetam but modified?
Click to expand...
There's no problem reaching out. I doubt there's any significant update though.
 
#75
Lucifer said:
If it's a remake of Trobalt hopefully there's no visual snow as a side effect.
Click to expand...
That's exactly what he's trying to fix, and possibly the effectiveness for tinnitus.

The endpoint for this drug is to be specifically for tinnitus, it is not being remade for the purpose of the original epilepsy drug. This is being designed for us.
 
#78
Re: Trobalt & Prof T's potential potassium opener / Trobalt reboot drug -

I believe ATEOS used Trobalt before it went off the market in 2017 and if I recall correctly, he felt it was the treatment that got his tinnitus from a 4/10 to a 1/10. Trobalt wasn't a lifelong drug - the max course was a few months.

I mean, if someone said to me "here's a drug that probably can help your Tinnitus, but it has some likelihood of turning parts of your skin and eyes blue" I think my next question would be "how blue?" Not to be insensitive, but that side effect may actually be better than tinnitus.
 
#79
LostOutWest said:
Re: Trobalt & Prof T's potential potassium opener / Trobalt reboot drug -

I believe ATEOS used Trobalt before it went off the market in 2017 and if I recall correctly, he felt it was the treatment that got his tinnitus from a 4/10 to a 1/10. Trobalt wasn't a lifelong drug - the max course was a few months.

I mean, if someone said to me "here's a drug that probably can help your Tinnitus, but it has some likelihood of turning parts of your skin and eyes blue" I think my next question would be "how blue?" Not to be insensitive, but that side effect may actually be better than tinnitus.
Click to expand...
People were also getting visual snow, but that's why it's being remade to benefit us.
 
#80
Anyone else think it's a weird coincidence that Knopp Biosciences is in pre-clinical for a tinnitus drug using the same potassium ion channel receptor as Dr. Tzounopoulos while also being in the same city as him? He's not listed on their webpage but I do wonder...
 
#82
mrbrightside614 said:
Any idea of when the interview with Prof. Tzounopoulos might drop? Need something to lift my spirits before Christmas.
Click to expand...
Bad news:

We had scheduled the interview with Prof. Tzounopoulos, and had already carried out a test recording with his secretary, but then, at the last minute, Prof. Tzounopoulos cancelled and wanted to postpone the interview stating that his schedule is just too busy for the next several months to be able to dedicate 2 hours on a recording (which is what we need to allocate for an exhaustive interview). Basically he doesn't yet know an exact time frame when he will have enough spare time, so it's anybody's guess when it might happen.

We very much look forward to having him on the Tinnitus Talk Podcast though, and hopefully it can happen sooner rather than later.

Therefore, our next episode published will be an interview with the President of the Hyperacusis Research, Bryan Pollard, to be released later this month.
 
#89
I hate to say this, but this doesn't sound like promising news at all.

Can we start an e-mail campaign to see why he is dodging the bullet on us?
 

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