@attheedgeofscience also was among the few with permanent improvement from Trobalt, so it's certainly possible.That sounds good. Bad side effects usually appear when you take a drug for a long time.
@attheedgeofscience also was among the few with permanent improvement from Trobalt, so it's certainly possible.That sounds good. Bad side effects usually appear when you take a drug for a long time.
I wonder what this means for other causes. Obviously treating underlying conditions is the first route to go down, but if that doesn't work (eg brains not adjusting accordingly anymore), how effective would it be?
Or, those with damage elsewhere in their ears? If it's targeting the brain's abnormal response to (any) damage within the auditory pathway, I hope it works for those without clear cochlear injuries too...
But time will tell. I do hope it'll be available and effective to those with chronic tinnitus too.
In theory yes, since the channel opener calms these hyperactive neurons down and this should also benefit hyperacusis. In the clinical trial they will also have hyperacusis patients.
- Is RL-81 also supposed to help pain hyperacusis?
I think pain hyperacusis is just the nasty little brother of tinnitus and what might help against either of them might help also against the other. This drug sounds promising but I think we will first get a shot of FX-322 before we can test if the redesigned Trobalt solves our auditory problems.
I wasn't able to watch the whole presentation. It seemed to be more intended for Thanos (nice name, heh) to establish his credibility.
Did they say how much they expect this drug to improve symptoms? Is it too early to tell?
It apparently works very well enough in rodents that they expect to move into clinical testing in humans in about a year and a half. His main concern seemed to be making sure it didn't have the side effects of Trobalt but they believe they can make it more selective and therefore both safer and more effectiveI wasn't able to watch the whole presentation. It seemed to be more intended for Thanos (nice name, heh) to establish his credibility.
Did they say how much they expect this drug to improve symptoms? Is it too early to tell?
The last sentence of the conclusion in the book "Hyperacusis and Disorders of Sound Intolerance: Clinical and Research Perspectives" 2018 from Marc Fagelson and David Baguley says in the last sentence of the conclusion:Really curious to see whether this will be beneficial for noxacusis. Based on this it suggests that this kind of drug could be helpful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664349/
Also wondering whether potential treatments for pain hyperacusis, if they're targeting the type 2 nerve fibers in the cochlea would be local delivery or would a general pill be effective?
The clinical trials are taking place in a year and a half. When can we imagine the drug coming out?
Yeah I guess it also depends on whether they decide to apply for breakthrough status or fast-tracking.There is usually 3 phases for clinical testing. Maybe 6 years or more. Am I wrong?
I'd say 5-10 years, yeah. Which seems like a very long time, but if it's going to have similar benefits many reported having from Trobalt... I'd say it's worth it, no? Maybe that's just because I'm still young and would still have a lot of youth to enjoy in 10 years.There is usually 3 phases for clinical testing. Maybe 6 years or more. Am I wrong?
I'd say 5-10 years, yeah. Which seems like a very long time, but if it's going to have similar benefits many reported having from Trobalt... I'd say it's worth it, no? Maybe that's just because I'm still young and would still have a lot of youth to enjoy in 10 years.
I have hopes this works for chronic cases too.
Yes. It's a long time. Probably we will have FX-322 available sooner. But it's good to have two alternatives. If FX-322 does not work.. you have the pill.
I hope it works for chronic cases too. I'm trying to be optimistic.
This is encouraging to hear - Paul Fuchs from Johns Hopkins seems to think pain hyperacusis is more likely peripheral.The last sentence of the conclusion in the book "Hyperacusis and Disorders of Sound Intolerance: Clinical and Research Perspectives" 2018 from Marc Fagelson and David Baguley says in the last sentence of the conclusion:
Moreover, if the induction of auditory pain in hyperacusis is at the periphery, then the side effects of retigabine (and those of any other new drug) could be minimised if delivered locally through systems for drug administration to the inner ear and we might thus see some progress toward clinical trials in the not too distant future.
Its a dark comedy...Exactly, we can't put our eggs in one basket.
If FX-322 fails us, there are still other regeneration projects being developed like Hough's pill. If all regeneration meds fail to silence our tinnitus, maybe this will help us.
Going from phase 1 to a full release can easily take 10 years. We have to be patient. The safety tests exist for a reason.
What phase is Xenon Pharma in at the moment?This is encouraging to hear - Paul Fuchs from Johns Hopkins seems to think pain hyperacusis is more likely peripheral.
I've also seen Liberman discussing the possibility of developing drug therapies to selectively block the type 2 nerve fibers.
There are also other companies working on new and improved versions of retigabine, mainly for epilepsy, e.g. Xenon Pharma. Wonder if these could also be beneficial.
Its a dark comedy...
So yesterday I went to the doctor... she, he told me to come back in 13 years and charged me 200 dollars for the consultation.
Hang in there Daniel. Well make it through these dark times together. There are definitely brighter days ahead (hug).Its a dark comedy...
So yesterday I went to the doctor... she, he told me to come back in 13 years and charged me 200 dollars for the consultation.
Maybe the dosage was not sufficient. Do you know others who have taken Trobalt for tinnitus?I did try Trobalt for 2 months with no positive effect on my tinnitus. Luckily I experienced no side effects either. I wonder if RL-81 is to be more potent than Trobalt, if not then I think only a few lucky ones may benefit from it. I don't put much of my hopes in it.
They have several products in their pipeline - the one that's furthest along is about to start Phase 3 trials.What phase is Xenon Pharma in at the moment?
With hyperacusis would we need to continue taking Retigabine everyday or would we only need to take it until it goes away?
Thanks HootOwl.Hang in there Daniel. Well make it through these dark times together. There are definitely brighter days ahead (hug).
I'm in Australia. How can I get in on this ?Clinical trials in Australia. That's shocking. I wouldn't have expected they would do clinical trials there. I wonder why they would choose to do clinical trials there and not USA.
It won't be soon. They stated in a year or two they will start human clinical trials.I'm in Australia. How can I get in on this ?
I can't recall the dosage. It was already like 3-4 years ago, but I followed Danny Boy's recommendation who was most experienced with it.Maybe the dosage was not sufficient. Do you know others who have taken Trobalt for tinnitus?
I agree, Prof. Thanos is reformulating Trobalt to reduce toxicity, Trobalt did not cure tinnitus, not even close.I did try Trobalt for 2 months with no positive effect on my tinnitus. Luckily I experienced no side effects either. I wonder if RL-81 is to be more potent than Trobalt, if not then I think only a few lucky ones may benefit from it. I don't put much of my hopes in it.