Pu-Erh Tea and GABA Attenuates Oxidative Stress in Kainic Acid-Induced Status Epilepticus
- Thread starter Danny Boy
- Start date
Member
Abstract
Background
Pu-Erh tea is one of the most-consumed beverages due to its taste and the anti-anxiety-producing effect of the gamma-aminobutyric acid (GABA) if contains. However the protective effects of Pu-Erh tea and its constituent, GABA to kainic acid (KA)-induced seizure have not been fully investigated.
Methods
We analyzed the effect of Pu-Erh tea leaf (PETL) and GABA on KA-induced neuronal injury in vivo andin vitro.
Results
PETL and GABA reduced the maximal seizure classes, predominant behavioral seizure patterns, and lipid peroxidation in male FVB mice with status epilepticus. PETL extracts and GABA were effective in protecting KA-treated PC12 cells in a dose-dependent manner and they decreased Ca2+ release, ROS production and lipid peroxidation from KA-stressed PC12 cells. Western blot results revealed that mitogen-activated protein kinases (MAPKs), RhoA and cyclo-oxygenase-2 (COX-2) expression were increased in PC12 cells under KA stress, and PETL and GABA significantly reduced COX-2 and p38 MAPK expression, but not that of RhoA. Furthermore, PETL and GABA reduced PGE2 production from KA-induced PC12 cells.
Conclusions
Taken together, PETL and GABA have neuroprotective effects against excitotoxins that may have clinical applications in epilepsy.
Background
Pu-Erh tea is one of the most-consumed beverages due to its taste and the anti-anxiety-producing effect of the gamma-aminobutyric acid (GABA) if contains. However the protective effects of Pu-Erh tea and its constituent, GABA to kainic acid (KA)-induced seizure have not been fully investigated.
Methods
We analyzed the effect of Pu-Erh tea leaf (PETL) and GABA on KA-induced neuronal injury in vivo andin vitro.
Results
PETL and GABA reduced the maximal seizure classes, predominant behavioral seizure patterns, and lipid peroxidation in male FVB mice with status epilepticus. PETL extracts and GABA were effective in protecting KA-treated PC12 cells in a dose-dependent manner and they decreased Ca2+ release, ROS production and lipid peroxidation from KA-stressed PC12 cells. Western blot results revealed that mitogen-activated protein kinases (MAPKs), RhoA and cyclo-oxygenase-2 (COX-2) expression were increased in PC12 cells under KA stress, and PETL and GABA significantly reduced COX-2 and p38 MAPK expression, but not that of RhoA. Furthermore, PETL and GABA reduced PGE2 production from KA-induced PC12 cells.
Conclusions
Taken together, PETL and GABA have neuroprotective effects against excitotoxins that may have clinical applications in epilepsy.
If you intend to consume Pu-Erh tea you might just want to first look over the "Interactions" list from the webmd.com website to determine if you are using/consuming some of the listed meds/drugs and other substances. Click on "Interactions":
http://www.webmd.com/vitamins-supplements/ingredientmono-1169-PU-ERH TEA.aspx?activeIngredientId=1169&activeIngredientName=PU-ERH TEA
http://www.webmd.com/vitamins-supplements/ingredientmono-1169-PU-ERH TEA.aspx?activeIngredientId=1169&activeIngredientName=PU-ERH TEA
Only me it seems. Does make you really happy! So really does give you that GABA boost!
It lowered it for me, but maybe I was just happy and ignored my tinnitus? Either way, it's worth a try. It's healthy, helps battle depression and can make your skin glow ^_^.
Danny, in the article COX2 is mentioned. In your research have you come across any information regarding either COX or LOX as being a contributor to Tinnitus type neuro excitatory behaviours? The reason I ask is there are quite a few proven natural COX and LOX inhibitors in use at the moment which act in an anti inflammatory capacity.
Religious drinker and professional pourer of pu-erh for years leading up to when I got tinnitus. Pu-erh has high levels of Mycotoxins. Beware this is not a tinnitus fix and may make matters worse.
Log in or register to get the full forum benefits!
Similar threads
