Cool.
It has been shown in human clinical trials that IGF-1 eardrum injections may very well be capable of restoring hearing loss by regenerating hair cells, at the least protecting them from apoptosis, which is what's most important to the topic of this forum.
Dexamethasone steroid injections also have been shown to be effective at preventing permanent hearing loss when injected quickly after acoustic trauma. Neither of these things are being offered as a standard intervention for acoustic trauma.
This is not a popularity contest. This is not a contest at all. Let's work together to cure tinnitus. The BTA isn't doing that. They are actually not very transparent in their decision making processes. They are funding research into non curative studies while downplaying the effectiveness of things like dexamethasone treatment which is contradictory to published medical science.
Here is a breakdown of that study:
First from the BTA:
https://www.tinnitus.org.uk/2018-at...lliance-tinnitus-priority-setting-partnership
"The steroid dexamethasone was used on 27 patients, with 27 others in the control group receiving a saline injection.
There was some improvement in both groups, but there was no significant difference between them [46]."
[46] Choi SJ, Lee JB, Lim HJ, In SM et al. Intratympanic dexamethasone injection for refractory tinnitus: prospective placebo-controlled study.
Laryngoscope. 2013: Nov 123(11): 2817-22. doi: 10.1002/lary.24126
I have access to the full text of this study.
Now we aren't even talking about IGF-1. PRP. Me. Minbo Shim. Whatever.
We are talking about the detrimental incompetence of the British Tinnitus
Association.
Analysis of he aforementioned study:
View attachment 29794
Introduction:
"Thirty patients with
refractory tinnitus who were
diagnosed in the Department of Otolaryngology, Ajou University Hospital, Suwon, Republic of Korea,
between 2006 and 2007 were enrolled and then were assigned into two groups of ITDI (15 patients) or saline (15 patients) by permuted block randomization. Intratympanic injections were double‐blind performed four times within 2 weeks. After 4 weeks, we analyzed the improvement and aggravation rates of tinnitus using the following parameters: questionnaires, tinnitus handicap index (THI), loudness matching test, frequency, and duration of tinnitus."
"This work was supported by Konyang University Myunggok Research Fund of
2009."
Source:
View attachment 29795
So this study was performed between 2 to 3 years after they were diagnosed with tinnitus. Of course intratympanic steroids wouldn't help them. Their hair cells would have long been dead (apoptosis).
The whole point of dexamethasone intervention is to be administered quickly, shortly after acoustic trauma, to prevent hair cell apoptosis (death of the hair cell).
The previous paper I've cited numerous times regarding IGF-1 treatment vs dexamethasone had populations that improved in both groups, but intervention occurred quickly,
within 25 days, not 2 to 3 years.
"Patients who had been diagnosed as having SSHL and who had no recovery after systemic glucocorticoid treatment for more than 7 days were recruited within 25 days of SSHL onset"
Source:
View attachment 29796
The BTA is very influential in the tinnitus world of academia. They are quoted in college level textbooks about tinnitus and hyperacusis. They are dismissing and ignoring interventions that may have very well helped the majority of us avoid chronic hearing loss and tinnitus, if we had had access to them as soon as we first acquired our acoustic traumas. However, the main intervention being offered to us is oral steroids, which from the accounts of patients on this forum, including myself, is obviously ineffective. So why is that even the main intervention? Oral steroids? Wouldn't intratympanic steroids be more effective? Topical vs. systemic application? The science points to a more effective result when administered intratympanically shortly after onset of hearing loss. However, the mention of IT dexamethasone use from the BTA's website just downplays any use of this, while not mentioning that the study they sourced was on patients that were years into their onset. It seems as if they are making arguments against effective interventions while taking money and funding non-curative research into mindfulness. Am I the only one that sees how detrimental this is? Their actions are possibly increasing the number of people that don't recover from tinnitus, while also not funding research into the very things that may reverse it. Their very existence could be delaying any progress whatsoever.
Maybe the BTA staff have good intentions, but maybe they are not equipped to handle their level of influence.