Vitamin Supplement (Nicotinamide Riboside) Successfully Prevents Noise-Induced Hearing Loss

[exodus]

Researchers from Weill Cornell Medical College and the Gladstone Institutes have found a way to prevent noise-induced hearing loss in a mouse using a simple chemical compound that is a precursor to vitamin B3. This discovery has important implications not only for preventing hearing loss, but also potentially for treating some aging-related conditions that are linked to the same protein.

Published today in Cell Metabolism, the researchers used the chemical nicotinamide riboside (NR) to protect the nerves that innervate the cochlea. The cochlea transmits sound information through these nerves to the spiral ganglion, which then passes along those messages to the brain. Exposure to loud noises damages the synapses connecting the nerves and the hair cells in the cochlea, resulting in noise-induced hearing loss.

The researchers set about trying to prevent this nerve damage by giving mice NR before or after exposing them to loud noises. NR was successful at preventing damage to the synaptic connections, avoiding both short-term and long-term hearing loss. What's more, NR was equally effective regardless of whether it was given before or after the noise exposure.

"One of the major limitations in managing disorders of the inner ear, including hearing loss, is there are a very limited number of treatments options. This discovery identifies a unique pathway and a potential drug therapy to treat noise-induced hearing loss," says Kevin Brown, MD, PhD, an associate professor of otolaryngology-head and neck surgery at the University of North Carolina School of Medicine and first author on the paper. Brown conducted the research while at Weill Cornell.

The researchers chose NR because it is a precursor to the chemical compound nicotinamide adenine dinucleotide (NAD+), which had previously been shown by Dr. Brown and co-senior author Samie Jaffrey, MD, PhD, to protect cochlea nerve cells from injury. However, NAD+ is an unstable compound, calling into question whether it could be used out of the petri dish and in a live animal. That led the scientists to use NR instead.

Methods for synthesizing NR were recently developed by Anthony Sauve, PhD, a professor of pharmacology at Weill Cornell and co-author of the study. This resulted in quantities of NR that were sufficient to test in animals.

"NR gets into cells very readily and can be absorbed when you take it orally. It has all the properties that you would expect in a medicine that could be administered to people," said Dr. Jaffrey, a professor of pharmacology at Weill Cornell.

Beyond just preventing hearing loss, the researchers think the results may have broader applications because of the underlying way NR protects nerve cells. The scientists showed that NR and NAD+ prevent hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in the function of mitochondria, the powerhouses of the cell.

The researchers hypothesized that it was this enhancement of SIRT3 that was behind the protective properties of NR. To test this, they manipulated SIRT3 levels independently of NR to see if they could still prevent noise-induced hearing loss by administering NR. Sure enough, deleting the SIRT3 gene in mice abolished any of the protective properties of NR. The researchers also showed that a new strain of mice, generated in the lab of co-senior author Eric Verdin, MD, at the Gladstone Institutes and engineered to express high levels of SIRT3, were inherently resistant to noise-induced hearing loss, even without administration of NR.

SIRT3 decreases naturally as we age, which could partially explain aging-related hearing loss. Additionally, some individuals carry different versions of the SIRT3 genes that result in reduced enzyme activity, which may make them more susceptible to noise-induced hearing loss.

Dr. Verdin, an investigator at the Gladstone Institute of Virology and Immunology and professor of medicine at the University of California, San Francisco, says, "The success of this study suggests that targeting SIRT3 using NR could be a viable target for treating all sorts of aging-related disorders—not only hearing loss but also metabolic syndromes like obesity, pulmonary hypertension, and even diabetes."

http://medicalxpress.com/news/2014-12-vitamin-supplement-successfully-noise-induced-loss.html


Amazon US:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count
• N (R) Niagen Nicotinamide Riboside - (3 pack) - 60 capsules per bottle

Amazon UK:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count

 

[J-rod]

Nicotinamide Riboside occurs naturally in beer and milk.

Has anyone tried taking Nicotinamide Riboside supplements?

 

[NeverLoseHope]

Nicotinamide Riboside occurs naturally in beer and milk.

Has anyone tried taking Nicotinamide Riboside supplements?

This is an interesting one I need to look into more.

I guess it would be worth a try, but it can spike you for a few hours as well if it is not for you.

 

[NeverLoseHope]

I have just bought some:

Amazon US:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count
• N (R) Niagen Nicotinamide Riboside - (3 pack) - 60 capsules per bottle

Amazon UK:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count

 

[exodus]

I have just bought some:

Amazon US:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count
• N (R) Niagen Nicotinamide Riboside - (3 pack) - 60 capsules per bottle

Amazon UK:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count

Is Vitamin B3 (Niacin/Niacinamide) the same as Nicotinamide Riboside (NR)?

The study used Nicotinamide Riboside, and it was the form that was deemed effective in preventing noise-induced hearing loss.

 

[NeverLoseHope]

Is Vitamin B3 (Niacin/Niacinamide) the same as Nicotinamide Riboside (NR)?

The study used Nicotinamide Riboside, and it was the form that was deemed effective in preventing noise-induced hearing loss.

Read this:
http://www.ncbi.nlm.nih.gov/pubmed/24071780

 

[exodus]

Read this:
http://www.ncbi.nlm.nih.gov/pubmed/24071780

I am confused.

I think that there are multiple sources of Vitamin B3; the regular Vitamin B3 (Niacin/Niacinamide) and the one they've experimented with and which is sold under the name of Nicotinamide Riboside.

Examples of Nicotinamide Ribose here:

Amazon US:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count
• N (R) Niagen Nicotinamide Riboside - (3 pack) - 60 capsules per bottle

Amazon UK:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count

My conclusion is that Nicotinamide Riboside is more neuroprotective than Vitamin B3 (Niacin/Niacinamide).

And you can see the prices are not the same. Nicotinamide Riboside is far more expensive than Vitamin B3 (Niacin/Niacinamide).

 

[Mosaik]

I was just going to post this, and yes, you are right. B3 supplements are not likely to contain any NR.
Link to the same article on sciencedaily:
www.sciencedaily.com/releases/2014/12/141202123840.htm

 

[NeverLoseHope]

Thanks I will get them as well, sorry I had a tough night last night.

 

[mintblue]

Never tried Niacin or any B3 before but it couldn't hurt. Just ordered some Nicotinamide Riboside and will try the whole bottle. Cheers!

 

[Katkin]

Niacinimide Riboside occurs naturally in beer and milk.

Beer and milk sounds like a good option to me, not together of course though!

 

[Mosaik]

I am really looking forward to this. Right now I have a fear of sounds and if NR would be confirmed to have the same effect on humans, my fears would go away. Since this works on a really low level I hope that it has a good chance to work the same as well, maybe the research team would be able to answer this, I think I will contant them.

For those of you who ordered 'Niagen Nicotinamide Riboside' please report your experiences ASAP, if there are any. I might order it today as well.
Cheers!

 

[AnnaW]

Anyone found a dosage in the study?

 

[Markku]

Anyone found a dosage in the study?

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00500-2

Anyone here happen to have access to the full text article?

 

[AnnaW]

http://www.longecity.org/forum/topi...riboside-nrniagen-personal-experience-thread/

Some info above, haven't had a chance to read it properly yet...

 

[LadyDi]

Looks like this research looks specifically at tinnitus caused by noise exposure. Wonder if the supplement has any affect on T not caused by noise, like mine. Still: Couldn't hurt to give it a try. I have had some relief with NAC.

 

[EatMoTacos]

http://www.google.com/patents/WO2014014828A1?cl=en

This might help.

 

[mintblue]

I'm two days in and have taken 2 pills (2 x 250 MG = 500 MG/day) each morning before food. I'm not gonna report anything about my experience until I finish the bottle, which should take a month. See you guys in 2015!

 

[Zaxdad]

Just ordered a bottle. Willing to try anything at this point. Still don't see what the recommended daily dosage is though.

 

[AnnaW]

It seems as though they start at a low dose and work upwards depending upon at what level patients experience improvement. I think I have seen 300mg/day somewhere too but not sure where now sorry.

 

[OptimusPrimed]

http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00500-2

Anyone here happen to have access to the full text article?

Yes. There isn't anything in the article that directly mentions tinnitus. They mention the 24 hour nerve cell death window and how NR may be a form of emergency treatment to prevent permanent damage. Limitations such as person-to-person variation in effectiveness are also emphasized.

 

[mintblue]

IMPORTANT NOTE: If you bought this supplement off Amazon http://www.amazon.com/Niagen-Nicoti...sim_hpc_2?ie=UTF8&refRID=0964Q7BZCXYRWYQ6Z7N0

The capsules are kind of hardy, I tried dissolving two in water this morning and this is what they looked like after 25 minutes.

http://imgur.com/a/TYstT

Barely dissolved. I'm not saying that they wouldn't dissolve better in our stomachs with bile and 98.6 F temperature, but I'm going to take my pills apart and dissolve the B3 in water from now on.

 

[OptimusPrimed]

IMPORTANT NOTE: If you bought this supplement off Amazon http://www.amazon.com/Niagen-Nicoti...sim_hpc_2?ie=UTF8&refRID=0964Q7BZCXYRWYQ6Z7N0

The capsules are kind of hardy, I tried dissolving two in water this morning and this is what they looked like after 25 minutes.

http://imgur.com/a/TYstT

Barely dissolved. I'm not saying that they wouldn't dissolve better in our stomachs with bile and 98.6 F temperature, but I'm going to take my pills apart and dissolve the B3 in water from now on.

Have you noticed any improvement yet

 

[mintblue]

Have you noticed any improvement yet

I'll let you know when I finish the bottle

 

[Mosaik]

Do they have shiny coating? I guess it is meant to be digested like that
https://en.wikipedia.org/wiki/Pill_(pharmacy)
vs
https://en.wikipedia.org/wiki/Tablet_(pharmacy)

 

[Zaxdad]

Took my first two this morning. Here's hoping.

 

[Manuel Tissm]

Took my first two this morning. Here's hoping.

Good luck. Keep us informed.

 

[LeQuack]

I am confused.

I think that there are multiple sources of Vitamin B3; the regular Vitamin B3 (Niacin/Niacinamide) and the one they've experimented with and which is sold under the name of Nicotinamide Riboside.

Examples of Nicotinamide Ribose here:

Amazon US:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count
• N (R) Niagen Nicotinamide Riboside - (3 pack) - 60 capsules per bottle

Amazon UK:

• Life Extension NAD+ Cell Regenerator Nicotinamide Riboside Capsules, 30 Count

My conclusion is that Nicotinamide Riboside is more neuroprotective than Vitamin B3 (Niacin/Niacinamide).

And you can see the prices are not the same. Nicotinamide Riboside is far more expensive than Vitamin B3 (Niacin/Niacinamide).

I ordered it directly from their own store:
https://www.lifeextensioneurope.com/catalogsearch/result/?q=Nicotinamide+

Shipping is 5€ across EU, since the Amazon UK store I think only sends to UK.

 

[spingee]

I ordered it directly from their own store:
https://www.lifeextensioneurope.com/catalogsearch/result/?q=Nicotinamide

Shipping is 5€ across EU, since the Amazon UK store I think only sends to UK.

What is the difference between those two?

 

[LeQuack]

The more expensive one has some other stuff in there apparently.