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I just became a Super Patreon of the Tinnitus Talk Podcast. I hope Tinnitus Talk is going to achieve even more in the future!

Has anyone seen the papers related about gamma secrete inhibitor, like this: https://www.ncbi.nlm.nih.gov/pubmed/23312516 From this paper I find the drug works much better at the apex area of the cochlear than the base. I am afraid Regain may not be efficient for high frequency hearing loss.

What are the cons?

Where did they say this?

Sorry it's just my guess. Your reply may answer my question. Comparison is only one of the aims in phase 3. So they may not skip it.

I find that generally the aim of a phase 3 trial is to compare the effects of a new drug with a present most useful drug. Since currently there exists no drug for hearing loss, so if phase 2 is successful, could FX-322 skip phase 3?

Here is the publication from Frequency Therapeutics: http://dx.doi.org/10.1016/j.celrep.2017.01.066. I just had a quick read and think the paper says they can expand the number of positive supporting cells. So maybe even if you have some injury to your supporting cells, the drug can still work.

That's sad. So when FX-322 comes, we all have some flat epithelium that may decrease the effect.

Does anyone know if the loss of hair cells cause damage to the supporting cells? FX-322 use supporting cells but if someone's supporting cells get hurt, it means nonsense? And it seems like there are different types of hair cells since they sense different frequencies, so FX-322 could...

I applied for an appointment, but I think I will be refused. I can't hear anything above 10 kHz in my bad ear, although my hearing is normal below 8 kHz. It's a steep decrease from 9 kHz. Maybe FX-322 can help me with my hearing and then I could try Lenire to solve my tinnitus.

I am sorry to hear that. Maybe @billie48's story can help you. And you can try Lenire, which is now taking to appointments.

So if phase 2a goes super well, the company will skip into phase 3 directly? I give huge confidence in FX-322 due to its theory. Did such things happen in past?

Can someone explain why phase 2 will be split into a / b / c sub phases? And I found CGF-166 has reached phase 2c, why does it get little attention?

I wish I can habituate it and one effective treatment will arrive within 10 years!

I am sorry to hear about your slight improvement. Besides hearing, do you feel any better about your tinnitus?

So does anyone find 7,8-DHF useful for improving hearing loss or tinnitus?

I really wonder do people hear their tinnitus when working? Tinnitus always distracts me from focusing on something. I am really sad. I am afraid that I can't do any job after graduation.

Does anyone know whether Lenire works on tinnitus with hearing loss? I got my tinnitus from sudden hearing loss in high frequencies and the tinnitus is high pitched which is rather annoying.

I am a grad student. Is there anyway to stay in Dublin for the whole period of treatment? I think I should try to find some international internship in Dublin but it seems there are not many opportunities.

So Lenire is the same as the University of Minnesota device?

So drugs like REGAIN, FX-322 and CGF166 for hair cell regeneration will work on both hair cells and nerves?

I got high-pitched T(7000hz maybe) and it can't be masked by the vent noise in my quiet office(I am a software intern in a IT company right now), so disturbing me a lot. I had hearing loss in ultra high freq. A quiet working env would be great to my hearing but it means the T is getting more...

It's quite hard to get a job in such countries, especially for people from China.

My PhD lab is dealing with AI and statistics. The rank of the Univ. is 32 according to QS. But actually I am not interested in Professor. The main goal for me to purse PhD is to get a high salary job in industry cause competition is fierce in China. Actually I am considering to talk with my...

@Yugal Rai Thx for your encouraging. I wish you can have a really nice univ. life!

@M.K. I now work as a short intern in a IT company(I want do something to distract from the T before my study), but I find the voice of vents cannot totally mask my T. I can still sense it but the volume of T is much lower. It's because I got high pitched T. I kinda struggle with it when...

Hello everyone, I am a year 4 college student and got sudden hearing loss with tinnitus this March. I went to ENT and got treatment for my hearing loss. My hearing improved a lot but my tinnitus still exists now. Actually I plan to earn PhD degree in CS this Sept. but I am really confused...