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You are really young so I think you’ll be able make a lot of improvement. Work on improving your general health, lifestyle and diet, you can still do a lot of things you wish to do but one advice is to be careful of the noise exposure. Normal situations are fine but my personal preference is to...

I have been taking Clonazepam and Mirtazapine daily for 2 years since the onset of this condition. Trying to get off them, it’s hard.

Hi Sarah, after reading your question carefully, my answer is I really can’t tell you whether it’s worth the risk or not. But it is a fulfilling job that I do like much more than my previous other jobs (engineer at a semicon). Yes, I do try to manage my classroom so that it’s quite quiet most...

Me too, I’m teaching in elementary school. It gets so busy that frankly I can’t stop to think too much of my tinnitus. That said, I have been careful with my noise exposure as far as I can. Every time there’s a lesson transition and noise levels increase, I’ll whip out my ear plugs and walk off...

Exercising and being more in the outdoors were some ways that really helped me. I also spent a lot of time with my loved ones and volunteered myself for all sorts of work.

You are young so you have have a very good chance of recovering. Be careful and protect your ears from loud noises. I was in a terrible shape at the beginning mentally and emotionally and started to feel better after one year plus.

INVESTIGATION ALERT: The Schall Law Firm Announces it is Investigating Claims Against Frequency Therapeutics, Inc. and Encourages Investors with Losses of $100,000 to Contact the Firm The company is under investigation for violation of securities law. I felt crushed after hearing the recent...

@stillsinging I wanted to share with you that I had very very extremely intrusive tinnitus for a year. Many times I wanted to kill myself and also did try but was stopped. I couldn’t sleep for days. Everyday I was crying in the middle of the night next to a fridge to mask tinnitus. I spent all...

Thanks and glad it was useful. Yes, it’s mind-blowing!

Thanks. The notes made by @FGG on his Tinnitus Talk Podcast interview helped a lot. I hope his preclinical trials go well. All of us are waiting and hoping.

I think he is talking about RL-81? I feel so down because he seems to say it only works for acute cases of noise induced tinnitus. I hope that’s not the case.

Even if the other ear is normal and doesn't have tinnitus?

Tinnitus Talk has been a lifesaver and hope for me. I truly appreciate the honesty here. I do not find it anywhere else. Thank you so so much to all! :):):):):)

On my good days, I don’t think about such things as you mentioned above but on my bad days I do wonder. But I’m glad I have people here who keep telling us to hold onto hope. That’s what I’m trying to do. No one understands how damaged ears damages life...

Could it be because there was a report on it here? https://finance.yahoo.com/news/strong-stocks-analyst-coverage-screener-012701683.html/URL]

This reminded me of a person who said her hyperacusis got so much better after CIs. But from what I read, they avoid destroying your existing cochlear tissue as far as possible.

I don’t mean to be misleading but it’s 100 percent correct. Tinnitus is generated by the brain, not the ears. The electrical signal sent by the ears through the nerve to the brain is interpreted as sound. With tinnitus, some population of neurons responsible for hearing synchronises and are...

I feel quite down because I can only increase my tinnitus when I clench my jaw. I cannot reduce it... Oh Lord, where on earth are my abnormal neural circuits?

Sorry, I’m not sure what you mean?

I just feel so sad this whole thing happened to me.

Personally, I think we should consider what @FGG mentioned about the difference between human adults and neonatal rats; the myelination makes a huge difference imo.

This clip explains the mechanisms of how hair cell synapses work. I think it might help you understand Dr. Thanos’ work much better.

From what I saw in that video, correct me if I am wrong, synapses talk to neurons, and then the neurons talk to the nerve? :)

A good clip explaining synapses. It’s from Catherine Weisz who discovered the role of the type II afferent synapses in the cochlear. She was then a graduate student in Paul Fuchs lab.

I was thinking about FX-322's mechanism of action and I don’t understand why the signalling is turned on in the small intestine but turned off in the cochlea. Since the LGR5 progenitor cells are relatively similar in these two areas, why did those in the cochlea get no more signalling after...

In the hardest bone of the human body(temporal bone)Sometimes I feel the same way as you too like the odds are against us. Goodness, to image the blood vessels require magnification equipment the size of a soccer goal net. I still hold onto hope.

Sorry and deeply pained to hear of this news. She was a loyal and kind wife. Deepest condolences to you, Dave...

I pray it be so!! :)

Me too, I’m on mirtazapine for 1 year and it only gave me gastric problems. But it was solved by taking it in between a meal. It made my sleep so much better.

Maybe they will just read out things we all already know but phrased differently?

He’s from UCI. Not the same person I think.

Maybe you’re right, I could have misread the principle and it works like a cochlear implant. But it was promising because it preserved hearing and was minimally invasive.

There’s a recent trial done by Fan Gang Zeng. Upon sending electrical stimulation to the cochlea in order to excite or activate those broken synapses, it stopped or reduced the tinnitus for half of the patients, though the tinnitus came back again. Disconnected synapses may not show up on...

I experience this as well, a morse code sound above car engines and car brakes. I didn’t even know how to put it in words. Thanks for giving it a name...

Thanks! Watching this clip just makes me treasure my imperfect hearing and feel I’m so so privileged to be given the gift of sound but sadly took it and so many things for granted foolishly.

The herb is reported to be poisonous if consumed in large amounts.

Yes, I caught it. But there was nothing new in her presentation...

I was happy reading all these good projections about FX-322 succeeding. The only hurdle is being able to finance the treatment. I’m not rich at all. But please fast forward to such a time! I’ll sell my house and get a shot. Still, it would be one of the TOP THREE best things that ever happened...

Could it be tinnitus sufferers' brains are somehow not as plastic as those who have recovered? Rather than the cochlear recovering and the brain responding to that recovery, it could be the brain was already compromised and therefore the insult from the cochlear triggers it. So the problem...

That’s a lot of NAC to take! I’m not sure about liver failure since NAC is used to prevent liver failure with aspirin overdose.

Yes, I agree. I don’t remember the name of that drug but they gave it systemically to the mice and most of them died of diarrhoea. I remember reading that it burned the mice' guts and those who survived were very thin.

I remember this article about middle ear muscle reflex changing after cochlear damage by Liberman. It says that when there’s damage in the inner hair cells, the middle ear muscle reflex is affected. So I think yes, all the ear structures are interrelated. Before I had this bad tinnitus and...

I think they were founders of the Frequency Therapeutics?

Yes, I think a reformulation would require another trial.

I’m worried about the delay... Is there some bad news from the trial results? Maybe I’m thinking too much into it? Frankly, the the Audion and Susan Shore delays have made me wary and a bit scared, I am worried it’s going to be like that, some vague excuse...

I am making a guess, it could be the temporal bone bank in MEEI. Then it would be a substantial number. It is not easy to get temporal bones so I think maybe they studied the temporal bones from MEEI.

I seem to understand why @dan feels the way he does. He could have seen too many failed trials/attempts over the years, from AM-101 to Retigabine and I lost track of the rest. But at the same time, I can see the science and phase 1 results so far for FX-322 that there’s something going on to...

Me too, I really pray that it is so :)

Thanks a million to @Hazel, @Markku, @Autumnly, @mrbrightside614, @FGG and all who put in much of their time, effort, money and labour to produce this podcast. I'm grateful that we have you representing the needs of our community! :)

The machines will be calibrated for this kind of testing, if not, there’s no point in doing the test at all.

I think that in an indirect way they are trying to ‘increase the concentration’ by repeating that safe phase 1 dose four times. To increase the concentration in a single dose would maybe entail a new round of trials. They won’t risk the unknown by using a different concentration on something as...

Yes, we could prevent more harm being done.

I’m sorry to pour cold water (I really hope I’m wrong), it’s mainly tested to work well on acute cases and for prevention.

From what I read, I think it seems to be working on calcium channel blockers... it is for acute cases or prevention mainly. When these calcium channel blockers are administered prior to cochlear damage they preserve hair cells. After the injury, these calcium channel blockers also do the same...

So maybe it’s because they only did the pre FX-322 audiograms up to 8kHz.

I was thinking for those four patients who showed clinical meaningful improvements, they could have asked them back and did a UHF audiogram? It is quite easy...

Thanks for clarifying @FGG and @Sloth :) Yes, that’s what I meant. You can maybe test for synaptopathy or at the very least inner hair cell function through acoustic reflex, but I’m not extremely certain about this.

sorry to hear about what you are going through, me too, I understand the desperation, hope you look at many people here who live with it and have a little hope, easier said than done, but look at the many other people who face it and this gives me some strength. Plus the fact that you are very...

And may I add something about synaptopathy from what I read recently. The spiral ganglion neurons are much more with regards to the number of inner hair cells. But one spiral ganglion cell synapses with ONLY and only one inner hair cell. The inner hair cell can have a few synapses extending...

Sorry but what do you mean? Is it something good?