Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

[_Patrick_]

So I'm guessing your ENT didn't believe in AM101 either? Maybe I'm confused on his definition of chemical solution, since Keppra helps me, Trobalt helps others, and if you want complete silence, get stoned off a Molly. I believe an Australian company is still trying to get to get the bottom why Molly (xtc) works?

Well, first of all there is a difference between "helps" and "cures". Of course, maybe in some cases, it does, and I'm glad it did for Danny Boy, but until now, research seem to consider it doesn't work any better than a placebo (and the failure of AUT63 is just about that).
He doesn't believe much in the AM101 approach either, he said the gel was very slimy, that it was particularly difficult to inject it, and that when people were asked if they wanted to continue with the study most of them refused.

 

[amandine]

Well, first of all there is a difference between "helps" and "cures". Of course, maybe in some cases, it does, and I'm glad it did for Danny Boy

Danny Boy is not cured.

 

[swc5150]

Yes, I definitely agree no one has been cured. Off the top of my head, I can't think of too many ailments that have been cured, like polio. A treatment is the best I'm hoping for. Keppra works great for me, as the reactive is what bothers me most, and Keppra stops it.

 

[amandine]

actually they have cured MS with stem cell treatment as has blindness....
http://www.dailymail.co.uk/news/art...patients-make-dramatic-recovery.html#comments
and
http://www.seattletimes.com/seattle...atment-halts-disease-lsquoin-its-tracksrsquo/

 

[swc5150]

actually they have cured MS with stem cell treatment as has blindness....
http://www.dailymail.co.uk/news/art...patients-make-dramatic-recovery.html#comments
and
http://www.seattletimes.com/seattle...atment-halts-disease-lsquoin-its-tracksrsquo/

Wow, that's awesome!

 

[Silvio Sabo]

actually they have cured MS with stem cell treatment as has blindness....
http://www.dailymail.co.uk/news/art...patients-make-dramatic-recovery.html#comments
and
http://www.seattletimes.com/seattle...atment-halts-disease-lsquoin-its-tracksrsquo/

Why isn't Stephen Hawking all over this one?!

 

[amandine]

Why isn't Stephen Hawking all over this one?!

He is! In Israel they have developed a cure or recovery in ALS (which S. Hawking has) using stem cells. This is since 2012 and there are now ongoing clinical trials together with USA. He may just have had it too long but no doubt he is very aware of it.

http://mfa.gov.il/MFA/InnovativeIsr...l-for-ALS-treatment-19-May-20150519-2015.aspx

 

[swc5150]

I can't believe this wasn't / isn't all over the news?! If this can't get airplay, just imagine how important the media thinks T is!

 

[Gill Hayes]

To be honest I don't care how important the media thinks T is as long as the scientist do that's good enough for me !

 

[Christian78]

I will try 101 and 102, and if there is autifony in USA i will get it and try it, i have family in USA...

 

[swc5150]

To be honest I don't care how important the media thinks T is as long as the scientist do that's good enough for me !

Agreed!

 

[Kate Winstol]

So this was just wishful thinking what a surprise. It will take a long time before there will be a cure because there needs to be so much more knowledge than there is today.

There are however some real science on how you can get used to the tinnitus by accepting it.

 

[Silvio Sabo]

So this was just wishful thinking what a surprise. It will take a long time before there will be a cure because there needs to be so much more knowledge than there is today.

There are however some real science on how you can get used to the tinnitus by accepting it.

Knowledge isn't always necessary. We discovered antibiotics by chance and at the time it wasn't known how it worked or why it worked. The important thing was that it DID WORK. We actually still don't know how aspirin really works and it's been around for almost 100 years. It's still pretty good when you have a headache though.

 

[t-man]

There are however some real science on how you can get used to the tinnitus by accepting it.

...I don't even.

 

[truesilence]

OMG! I few months back I tried to get onto the trial but was rejected because my hearing was normal. I've just received a voice mail from the research department at the Royal National Ear Nose and Throat Hosital asking me to contact them!!!!

 

[swc5150]

OMG! I few months back I tried to get onto the trial but was rejected because my hearing was normal. I've just received a voice mail from the research department at the Royal National Ear Nose and Throat Hosital asking me to contact them!!!!

You'll have to let us know what they say! Maybe they have a bunch of sugar pills to get rid of

 

[truesilence]

You'll have to let us know what they say! Maybe they have a bunch of sugar pills to get rid of

Lol! I hope not!! So strange as I received the call as I was having a consultation with the Neurologist and vowing never to step foot into a hospital again!

 

[Gill Hayes]

Hmm, interesting.

 

[truesilence]

Sorry, was getting my hopes up. It was just a call about my expenses. Oh well....

 

[shreddAr87]

I thought this thing didn't work anyways why are you sad?

 

[truesilence]

I thought this thing didn't work anyways why are you sad?

Because I stupidly thought it meant that the trial was possibly on again.

 

[JohnK]

Yes, I definitely agree no one has been cured.

Well, people have spontaneously resolved, but that doesn't count as a cure I suppose...

 

[skoupidis]

Well, people have spontaneously resolved, but that doesn't count as a cure I suppose...

Why shouldn't it? And who exactly is cured? After 1 year? 2 years? Did they take any treatment? The specifics are important...

 

[Christian78]

Autifony is dead, why do we speak about it???

 

[JohnK]

Indeed they are important but I don't know them. I just hear of people who spontaneously got better.

 

[Champ]

Autifony is dead, why do we speak about it???

Yeah there's plenty of other avenues on the horizon, time to move on

 

[Christian78]

Yeah there's plenty of other avenues on the horizon, time to move on

The only thing i see about Autifony is in USA. We will soon hear if they abolish reserch and that is it...

 

[Gill Hayes]

I think Champ was referring to Scifluor, Auris and Otonomy.

 

[Silvio Sabo]

The only thing i see about Autifony is in USA. We will soon hear if they abolish reserch and that is it...

I don't think they will stop their research. They might fail with the trial in US as well but that doesn't mean that they will shut down their business.

 

[attheedgeofscience]

I don't think they will stop their research. They might fail with the trial in US as well but that doesn't mean that they will shut down their business.

Fast forward a year from now and I doubt that Autifony Therapeutics will still exist. To my knowledge, Autifony Therapeutics does not have in-house research and so any further research will involve collaboration with an outside entity. I therefore do not think that we are likely to see"AUT00063 version 2.0" just around the corner.

Early stage research is unlikely to be undertaken (= financed) by a small pharma company. And even if Autifony Therapeutics did undertake such research, it would be a while before the fruits of such research could be harvested.

The above is, of course, just my opinion. Rather than speculating, asking Autifony Therapeutics for a statement would be the correct approach - although any response would probably be limited. I will, however, have to leave the liaison between TT and Autifony Therapeutics to someone else...