GABA Supplements (Including Picamilon)

[John Bacon]

I'm new here and will appreciate your feedback.

GABA Boost contains Phenyl-GABA which is the only form of the neurotransmitter, amino acid GABA capable of passing the blood-brain barrier in significant amounts to improve neurological functions. GABA Boost contains L-Theanine, which increases levels of GABA,prevents neurotransmitter overstimulation, and keeps the excitatory system in balance. It also contains Taurine which is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. GABA Boost is a fast-acting all-natural nutraceutical product that quickly reduces tension, anxiousness & stress while uplifting mood.

 

[calin]

I keep looking at a GABA supplement, but I already take l-theanine and taurine. I also take 12 grams of inositol.

I took a neurotransmitter urine test and have not got back the results yet. I will wait until I find out what the report says before I go messing with more neurotransmitter supplement type products.

Gonna try it?

 

[mock turtle]

John Bacon, welcome to tinnitus talk...i haven't been around so long either but i can tell you the veteran members are smart and way cool people

regarding your question

ive tried gaba potentiating substances (alcohol for one), gaba analogues and gaba agonists (benzodiazepines)

especially β-Phenyl-γ-aminobutyric acid, aka, phenibut

it makes sense that gaba as an inhibitory neurotransmitter would have a calming effect on tinnitus, and for me and some others, it seems to do just that.

problem is, that in time one tends to need higher doses to maintain the effect...so in between periods of "help" there needs to be a period of abstention and pain...ok so its a trade off ...some better days for some that are not so good

problem is that repeated episodes of withdrawal can cause kindling

be ware of the effect known as kindling

http://en.wikipedia.org/wiki/Kindling_(sedative-hypnotic_withdrawal)

i take a low dose of a benzo (.5mg clonazepam , max, once a day and often, none) as needed (when i get in deep water so to speak)

but have made every effort not to build tolerance

best wishes
mock turtle

 

[Molan]

hello, you might want to look into Picamilon, It combines GABA with Niacin so it can cross the blood brain barrier and deliver it there. I haven't tried it yet so don't know if it's any good or not but I'm looking into taking it if it's safe.

http://en.wikipedia.org/wiki/Picamilon

 

[calin]

hello, you might want to look into Picamilon, It combines GABA with Niacin so it can cross the blood brain barrier and deliver it there. I haven't tried it yet so don't know if it's any good or not but I'm looking into taking it if it's safe.

http://en.wikipedia.org/wiki/Picamilon

My concern as well. If it was helpful I am thinking we would see more reviews on it.

 

[calin]

https://www.tinnitustalk.com/thread...tments-for-tinnitus-says-dr-tzounopoulos.296/

 

[Molan]

Hi Calin according to what I read on another forum it's quite new in terms of being used to treat Tinnitus. This is apparently why there is no data for Picamilon at this time. I think it might be worth a go though.

 

[calin]

Hi Calin according to what I read on another forum it's quite new in terms of being used to treat Tinnitus. This is apparently why there is no data for Picamilon at this time. I think it might be worth a go though.

Hey Molan... thanks

I searched reviews of it - http://www.amazon.com/dp/B004JZPPR0/?tag=tinntalk-20

If you try it please let us know how it goes. I can't be a guinea pig for everything! haha

 

[Molan]

Hi Calin, the oldest review on the amazon link was last september so that would seem to indicate this is quite new on the market relatively speaking.

Yes when I try it I will let everyone know of course! Might be a while though as I need to research it alot more and have some other things I want to try first. I'm happy to be the Guinea pig on this one!

 

[Peggyd]

I am new to the forum and wonder if anyone has heard of Gabatrol. It is phenyl-gaba and theannine as the product already mentioned. I tried a sample dose in my Natures Outlet store and although it seemed to really help the anxiety I have been struggling with lately due to a recent flare up of TMJ pain, the next morning I seemed to have a new second tinnitus sound in my left ear. I have had bilateral tinnitus for ten years now and really struggled to find a place of peace with it for a long time. Now, I am really worried about having taken this sample dose and blaming myself that this might have caused the new noise. I can't be sure since I have had a lot of pain from the TMJ problem and have taken a few doses of ibuprofen to cope with that. I would appreciate very much any opinion or help. Thanks.
Peggyd.

 

[tweak]

Tinnitus is supposed to be a side effect of Ibuprofen but only if you take loads of it. I think normal dosages are fine and you say you only took a few doses. I have taken minimum doses and and it didn't increase my t. This is my own personal experience though.

 

[Peggyd]

Tinnitus is supposed to be a side effect of Ibuprofen but only if you take loads of it. I think normal dosages are fine and you say you only took a few doses. I have taken minimum doses and and it didn't increase my t. This is my own personal experience though.

Thanks for the reply. Do you know anything about the Gabatrol (phenyl gaba)?

 

[Karl]

Peggyd-
If you took only a sample dose, it may be temporary.

I had a similar experience taking Gingo Biloba. Some people swear by it, saying that it reduces their tinnitus. When I took two pills, both my ears were humming away. I freaked out and didn't take another pill. I'm basically back to one-eared-T.

 

[mock turtle]

many threads ago there have been discussions about gamma amino butyric acid (gaba) the neurotransmitter that calms things down, an how it might affect tinnitus

some drugs like alcohol affect the porosity of the membrane that lets in gaba to the receptors

some drugs mimic or ad to the gaba in the brain

gaba has an alpha and a beta ligand and some drugs effect just one or the other "plug-in"

and some drugs seems to effect the number of ligands available..agonists

so as we can see the entire gaba thing is not simple at all

but heres an interesting twist

once again some interesting treatment research suggests that baclofen which is not a benzo but acts to affect gaba activity, may have a calming effect on tinnitus
Revisiting baclofen for the treatment of severe chronic tinnitus

Paul F. Smith*, Yiwen Zheng and Cynthia L. Darlington

• Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, and Brain Health Research Centre, University of Otago, Dunedin, New Zealand

http://www.frontiersin.org/Neuro-Otology/10.3389/fneur.2012.00034/full

i was re reading this article and found some issues worth reconsidering

there appears to be two kinds of baclofen, both with the same chemical formula but each with either a left or a right twist to one end of the molecule... L-baclofen versus D-baclofen

one works, (the L baclofen) and the other (D-baclofen) counter acts the effectiveness of L-baclofen !! so taking both "recemates" together nullifies the medicinal potential of baclofen

amazing

from wikipedia
In chemistry, a racemic mixture, or racemate (

/reɪˈsimeɪt/), is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule. The first known racemic mixture was "racemic acid", which Louis Pasteur found to be a mixture of the two enantiomeric isomers of tartaric acid.

 

[erik]

Baclofen is Gababb antagonist. I thought the only effect ones for T were related to Gaba-a. If l-baclofen can really reduce tone- and click-evoked hyperexcitability in neurons, then theoretically it should be effective for T.​

This part of the article is interesting...

"

There is also a new generation of novel GABA B​

receptor agonists, such as CGP7930 (Adams and Lawrence, 2007), which do not have the adverse side effects of baclofen but which may be useful for the treatment of tinnitus. It would unfortunate if the extensive use of racemic baclofen prevented these new GABA​

B receptor agonists from being investigated for their efficacy against tinnitus."​

 

[erik]

I took Picamilon for about a week and a few days, maybe not long enough but it didn't really do anything for me or my T

 

[calin]

I keep looking at a GABA supplement, but I already take l-theanine and taurine. I also take 12 grams of inositol.

I took a neurotransmitter urine test and have not got back the results yet. I will wait until I find out what the report says before I go messing with more neurotransmitter supplement type products.

Gonna try it?

My tests came back negative. I am normal in all levels.

 

[erik]

so does that mean you are going to try gaba sup?

 

[calin]

so does that mean you are going to try gaba sup?

Me?

Nope - don't need it....

I am taking l-theanine and taurine as supplements which I understand helps with GABA. Right?

 

[mistygreen]

I am looking for a GABA supplement.I have read number of good reviews about GABA supplement.I really feel that this supplement are good solution for tinnitus.

 

[erik]

Unfortunately regular Gaba supplements will not work. You have to use

Me?

Nope - don't need it....

I am taking l-theanine and taurine as supplements which I understand helps with GABA. Right?

Yes they are supposed to be able to cross the blood brain barrier unlike the actual "Gaba" named supplements. However, I think the way it gets to brain is complicated and there are many factors so no telling how much actually makes it there in the end...

 

[calin]

Unfortunately regular Gaba supplements will not work. You have to use​

Yes they are supposed to be able to cross the blood brain barrier unlike the actual "Gaba" named supplements. However, I think the way it gets to brain is complicated and there are many factors so no telling how much actually makes it there in the end...

Catechlamine test I took shows nothing abnormal.

 

[LadyDi]

Hey, since this seems to be one of the main Gaba threads, thought I would mention this...
I tried a supplement that was supposed to be "pure" Gaba capsules, nothing mixed in. They were 750 mg and I was told to take one, preferably in the morning without food.

First few days, I noticed I found I was getting very itchy across my back and arms. Then one morning, I suddenly was very short of breath, feeling weird. Turns out it was the Gaba. It's not a common reaction, but I discovered some people get it. Maybe the dose was too high but I cant break a capsule in half.

Have to say: when it comes to interacting with Gaba, alcohol actually is the one thing that lowers my T. Just a half of glass of wine and I notice a difference. I drink cautiously, given I also I am on low doses of alprazolam.

 

[christine kauhane]

Has anyone tried GABA or KAVA and if so do they help?

 

[Markku]

Has anyone tried GABA or KAVA and if so do they help?

Regular GABA doesn't cross the blood-brain barrier.

Read the above comments for some alternatives, e.g. Picamilon which is a combination of GABA and niacin and is able to cross the BBB.

Kava can be relaxing, but it also has some interactions with other medications, and other possible adverse effects.
http://en.wikipedia.org/wiki/Kava#Effects

I have first-hand experience of Picamilon, and while it may have had a very subtle effect of reducing my tinnitus, I haven't continued ordering it after my initial test. The hassle with the Finnish customs is a pain in the butt.

My previous post about Picamilon is here: https://www.tinnitustalk.com/thread...perception-in-an-animal-model.271/#post-11241

 

[Leo1994]

I just ordered picamilon, I hope it works, nothing has worked so far, and my tinnitus is driving me insane.

 

[5htp]

As far as I am aware, no supplements of any kind have shown to be more effective than placebo in reducing the tinnitus signal.

 

[Danny]

I just ordered picamilon, I hope it works, nothing has worked so far, and my tinnitus is driving me insane.

hello
I`ve just ordered picamilon myself,

 

[Leah]

Oh, don't like hearing that supplements don't work. Leo going insane here too.
Missing work etc.

 

[mat]

picamilon capsules or powder? and how much mg? 100 200 mg?