Not sure how one can compare fun for a couple of hours with say a 1% chance of a lifetime of suffering due to debilitating T, and choose to take that "calculated" risk.
Its not going to put off many people with 1% risk or 10% risk. Chances of getting lung cancer though smoking is around 15% but that doesn't put people entirely off. If no one took risks in life then no one would drink, smoke or take drugs as thee vices less so for drinking can have adverse long terms effects on health