My Posting Place
- Thread starter threefirefour
- Start date
MemberI find it strange or spooky seeing DannyBoy's image on threads... it just feels weird considering he's no longer with us... I don't know man. This illness is a killer. There are a few members I correspond with who are really close to ending it.
Fuck JohnAdams, this shit is killer...
Over and out.
My village had their yearly party... the music is so loud that windows shake. i checked into a hotel with the kids, they were really happy... there was a pool and western food. At one point we were chilling, and over the PA they announced they would practice testing the fire alarm system. Broke out my ear muffs, and was just fine. Felt really nice to be prepared... Tinnitus sucks, but being prepared is cool... wooopeee.
I feel the same way seeing DannyBoy's image and makes me pause for thought each time I see it. Another member Kristen Harper, who sadly took her life due to tinnitus and other problems. I had tried to help her when she first developed tinnitus. I never got the chance to correspond with DannyBoy.
Tinnitus is without doubt an horrific problem. Doesn't matter what the level of intensity it is, it's how it affects the person's mental and emotional wellbeing.
Michael
Not fuck you JohnAdams, I meant fuck this... came out wrong... sorry... not intended to you, meant for tinnitus in general... peace.
A right of passage... congratulations amigo.Michael Leigh has now placed me on ignore.
ATA and BTA have no clout.If anyone can help push the message out, it would have to be someone quite famous.
- Feb 17, 2017
- 10,400
- Tinnitus Since
- February, 2017
- Cause of Tinnitus
- Acoustic Trauma
Is it the case that in the "Lenire User Experiences" thread, there isn't one true success story?! Or have I missed a post that, in certain light, might be interpreted as a success?
I have noticed that as well. You'd think there would still be major hype about this considering it is now the time that people should be getting full results. At least as many if not more than the curcumin thread.
New Breakthrough on Human Hearing Disorders From an Unlikely Source: Zebrafish
By CARDIFF UNIVERSITY NOVEMBER 1, 2019
https://scitechdaily.com/new-breakt...-disorders-from-an-unlikely-source-zebrafish/
A team including scientists from Cardiff University has identified how specific genes can dictate the patterns of the tiny cells — so-called hair cells — within our ears that allow us to hear and process sounds.
Genetic factors are thought to cause more than 50 percent of all incidents of congenital hearing loss, with many attributed to the misalignment or damage of tiny hair cells.
These hair cells exist in their thousands within the cochlea and are 'tuned' to respond to different sounds based on pitch or frequency. This is due to a collective property called 'planar polarization', or the orientation in which the tiny hairs are laid out. When sound enters the ear, the hairs change the sound vibrations into an electrical signal that is sent to the brain, allowing us to recognize it.
Using zebrafish as a proxy, scientists have shed light on how changes to specific genes alter the coordinated direction that these cells are laid out.
By CARDIFF UNIVERSITY NOVEMBER 1, 2019
https://scitechdaily.com/new-breakt...-disorders-from-an-unlikely-source-zebrafish/
A team including scientists from Cardiff University has identified how specific genes can dictate the patterns of the tiny cells — so-called hair cells — within our ears that allow us to hear and process sounds.
Genetic factors are thought to cause more than 50 percent of all incidents of congenital hearing loss, with many attributed to the misalignment or damage of tiny hair cells.
These hair cells exist in their thousands within the cochlea and are 'tuned' to respond to different sounds based on pitch or frequency. This is due to a collective property called 'planar polarization', or the orientation in which the tiny hairs are laid out. When sound enters the ear, the hairs change the sound vibrations into an electrical signal that is sent to the brain, allowing us to recognize it.
Using zebrafish as a proxy, scientists have shed light on how changes to specific genes alter the coordinated direction that these cells are laid out.
FREQ is stirring up awareness. Good for us, imho.
https://scitechdaily.com/newly-developed-drug-treatment-could-potentially-treat-hearing-loss/
https://scitechdaily.com/researchers-restore-hearing-to-noise-damaged-ears/
https://scitechdaily.com/hair-restoration-method-generates-new-human-hair-growth/
https://scitechdaily.com/newly-developed-drug-treatment-could-potentially-treat-hearing-loss/
https://scitechdaily.com/researchers-restore-hearing-to-noise-damaged-ears/
https://scitechdaily.com/hair-restoration-method-generates-new-human-hair-growth/
I agree.
I spoke to the representative for Lenire (formerly 'MuteButton' ) at the Tinnitus Expo in Birmingham a couple of years ago, and she explained to me the thinking behind bimodal stimulation - the consecutive tongue-tip charge, and the audio input etc...
I asked her how that was supposed to reduce the actual 'noise level' that we all experience, and she said something about re-setting the neurological aspect of the condition.
The explanation was very unsatisfactory to me, and I was left feeling less than convinced, and highly skeptical.
My own belief is that the action of tampering with already compromised nerve cells and fibres in the cochlea carries the real possibility of causing even further damage.
Along with @Bill Bauer I await a 'credible' success story.
That's been my problem with them. They don't explain in detail on a neuronal level exactly how that calms down hyperactivity. Reset? Reset how? What's being reset? Ion channels? Neurotransmitter receptor sites? What?
We need to start following the clues available to us. There is now data about things calming tinnitus. Why would the Hough Ear pill and the Sound Pharmaceuticals pill quiet tinnitus? both of them, HPN-007 and Ebselen seem to just be powerful anti-oxidants. How does that work? Oxidative stress playing a role in the perpetuation of the damage we've done?
- Feb 17, 2017
- 10,400
- Tinnitus Since
- February, 2017
- Cause of Tinnitus
- Acoustic Trauma
Just de Moss told us it does and Ebselen has phase 2 data showing a 30% reduction in tinnitus volume
- Aug 21, 2014
- 5,049
- Tinnitus Since
- 1999
- Cause of Tinnitus
- karma
I have no opinion on Lenire.
The University of Michigan device significantly reduced my tinnitus after 2 weeks of use with no negative side effects, and it stayed significantly reduced for the two weeks which I continued to use the device. It was confirmed through objective volume matching in a sound-proof room at the UMich lab, that the actual volume of my tinnitus (and that of a number of other test subjects) had been reduced. The initial study was small, but double blinded, and the results were peer reviewed after aggregation before I was told anything (and are all very available now, if you look through Pubmed / scihub).
As far as "how" bimodal is supposed to work, there's really no mystery there either, because this was developed as a ground-up technology, meaning they induced tinnitus in animals, observed specific neuroplastic changes in a particular brain region, and developed a technology to (temporarily) reverse those changes by exploiting what we understand about spike-timing dependent plasticity.
This video is six years old now, but is still the best thing I have found as far as explaining what this stuff actually is and how it works
Note that when this video was recorded, this had only been demonstrated in lab animals. In 2014 we had a "phase zero" preclinical work where a bunch of lab techs with tinnitus who happened to be involved with the lab, zapped themselves with the device and said "yeah we think this works, let's do a phase I", and then a phase I was conducted.
The conclusion of the phase I, in general was:
* no one was harmed
* some people showed no benefit as measured by a reduction in tinnitus volume or self-reported annoyance
* some people showed a moderate benefit as measured by same
* some people showed a significant benefit as measured by same
Unlike Lenire, I do not believe any of the UMich Phase-I people said their tinnitus "went away". Also unlike Lenire, the overall response rate and overall impact is more modest. Also unlike Lenire, they have published real papers that show some of the sausage making behind their little aurdino beep zap box, which makes me think they're more likely to be operating in good faith than Neuromod, even if that is hardly a guarantee of success.
Here is UMich's Phase I:
https://www.ncbi.nlm.nih.gov/pubmed/29298868
7-8 dB average actual volume reduction as measured in a lab is nothing to sneeze at, that gets close to halving the volume (which more or less aligns with my experience).
I have no idea if this thing will work for you, or any other particular person, but I do know that if someone offered me the experimental device I used in the trial tomorrow for $15,000 -- I would loot my savings/retirement as needed without blinking. On the other hand, I have thus far resisted the urge to try Lenire for a third of that money.
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