Did some more research on Bacopa Monnieri with Synapsa:
Conclusion: Bacopa appears to upregulate GABA and acetylcholine which both seem to be a possible pathway to make the tinnitus back off a little bit.
Googled 3 references:
I) General
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Bacopa Monnieri is an adaptogen herb and a precursor to the GABA-boosting neurotransmitter serotonin, and it appears to upregulate
GABA binding sites with consistent, long-term use.
Bacopa supports dopamine and serotonin production, which is good for
GABA. But more importantly for tinnitus control, it can upgrade neural communication.
Aside from auditory symptoms, tinnitus can intensify anxiety, stress, and depression. Bacopa may increase the effects of key mood-boosting neurotransmitters including serotonin,
acetylcholine (*) , noradrenaline, and dopamine, helping you achieve a sense of calm and maintain mood balance.
(source)
II) Acetylcholine (*)
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1) Kilgard and his colleagues electrically stimulated the vagus nerve in rats, which runs from the brain's medulla to the abdomen. This releases chemicals such as
acetylcholine and norepinephrine, which can encourage changes in the brain. By pairing the stimulation with a high-pitched tone, the scientists were apparently able to halt the rats' tinnitus for more than three months.
(source)
2) Available evidence suggests that acetylcholine serves as a neurotransmitter for several centrifugal pathways of the auditory system, particularly olivocochlear and olivo-CN connections. Its effects are mostly excitatory in the CN as well as other locations, and it may function as a neuromodulator as well as a neurotransmitter.
(source)
@FGG @GBB sorry to tag you, you both seem knowledgeable.
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