Solsaem Clinic (Dr. Minbo Shim) Experience

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Not adipose.

Think about it.

Good question.

Yeah there'll be some scars. My left hip is still a little sore.

No clue, didn't look. Felt good, especially when it penetrated my iliac crest. The 6th time was the best.

Yes. He also gave me rhinitis surgery.

No, but that's a good idea. I think he was trying to use all the PRP for my ears.

I was there everyday for 12 days back to back except Sunday. They were taking a decent amount of my blood everyday. Every little bit counts.

I'll be honest, now that I'm back home and back to my daily life, this whole thing seems like a dream.

So here you say that you aren't sure that he got MSCs from the bone marrow. I guess now you do, glad that you conveniently remember now that we are debating it. Also, I'm not sure why you even bring this up, you and I both know that the MSC count must be low, but yet, you haven't shared us the count either, so how can we know? I doubt you actually know the count. Also, it is an autologous procedure, the robustness of the cells is less than allogenic, the MSC factor is hardly comparable.
 
Here you go again, making statements that you have no idea about. STOP THAT. PLEEAAASE!!!!

I had my bone marrow taken 6 times. So if anything, I probably had way more than normal.
Exactly, you have no idea how many MSCs you had. I don't even know what we're debating at this point except for how little you actually know about your own procedure. You are one to require the last word, so I'll let you have it.
 
So here you say that you aren't sure that he got MSCs from the bone marrow. I guess now you do, glad that you conveniently remember now that we are debating it.
What are you talking about? Were they pure MSC's no, I never said that. There are MSC's in bone marrow. Quit spamming up my thread with your pretentious, pointless arguments.
 
John, do you, or anyone, have any idea if the stem cells can help grow new spiral g cells, being injected into the middle ear?
I got bone marrow out 7 times. Dr Shim said there were stem cells from the marrow, but I don't know what the number might be.
He said the molecules could go thru the cochlear window, but stem cells could not go thru it.
I asked if he injects into the cochlear. He said not into the cochlear. Only into the middle ear.
Could the stem cells help in the middle ear?
 
I asked if he injects into the cochlear. He said not into the cochlear. Only into the middle ear.
I thought both the bone marrow adult stem cells and the PRP permeate through the round window into the cochlea during Dr. Shim's IT treatment?
 
I want to point out that I contacted Dr. Shim in early December and @JohnAdams in early January.
I visited stem cell clinic regarding MSCs and PRP around the time @JohnAdams went to Korea, before he reported any results from his treatment. In early January I also had a consultation with neuroENT who did intratympanic stem cells before in Russia. There's also a doctor in Ukraine who uses stem cells to restore hearing.

There has been no pressure from either John or Dr. Shim. I believe they are both good people who want to help others. I decided to take out a loan, because my situation was extremely bad and I knew that it started, because of temporary hearing loss in the left ear. Even though according to audiograms hearing fully recovered it was obvious that there was some hidden damage (probably cochlear synaptopathy, because OAE and DPOAE didn't report any abnormalities meaning hearing cells weren't damaged).
I did my own research and consulted with John about it. Before you decide to do anything you need to do your own research and decide if it has potential to work in your case.
I'm convinced that bone marrow derived MSCs and growth factors can restore hearing loss and there are studies and documentation available online regarding this.

In fact there's a drug that's being developed at Massachusetts Eye and Ear by Charles Liberman, Sharon Kujawa and Albert Edge (who's one of co founders of Audion therapeutics) that is based on growth factors and the research is being funded by United States Department of Defense.

https://patents.google.com/patent/US20190022101A1/en

Methods of treating or reducing the risk of developing hidden hearing loss by administering a small molecule Trk agonists (e.g., amitriptyline, imipramine, LM 22A4 (N,N′,N″Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide), 7, 8-dihydroxyflavone (DHF), 7,8,3′-Trihydroxyflavone (THF), Mab2256, neurotrophin-4 (NT-4), neurotrophin-3 (NT-3), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), N-acetylserotonin, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide (HIOC), deoxygedunin, LM-22A4, or tricyclic dimeric peptide 6 (TDP6)).

  • FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
  • [0002]
    This invention was made with Government support under Grant Nos. RO1 DC08577, RO1 DC007174, RO1 DC0188, P30 DC05209, awarded by the National Institutes of Health and Grant No. W81XWH-15-0103 awarded by the Department of Defense. The Government has certain rights in the invention.


@humptydumpty69 @kelpiemsp @GlennAz @GSC @7Thunder's
 
@JohnAdams,

When I read your results and experiences, I compare them to @attheedgeofscience's reduction of 50% tinnitus from MSCs, and his violent ear resets. PRP is a comparable concept regarding therapy, and so far it seems to be inferior when we are concerned with its efficacy. On this forum we have more people who have undergone genuine stem cell procedures than PRP, and so far, we have mixed stem cell results, but the ones who have results, seem to have better results than you. Not to mention, both procedures generally are executed outside of The West, and are both costly procedures. I find it logical to compare them.
The stem cell procedures were not injected into the tympanic membrane, that's a huge difference to me in what JohnAdams and GlennAz had. Totally different kettle of fish, for the latter reason alone. For me at least.
 
look @humptydumpty69 you are more than welcome to post on this thread, just try and keep the criticism constructive. Trust me, I totally understand your apprehension about this but just remember, I have not been pushing anyone to try this unless they are totally accepting of the risks involved and the commitment. I'd honestly like to see this be a $100 a pop kinda deal but it's just not the case right now and at this point I've explained it well enough to be basically open source.
 
Quit spamming up my thread with your pretentious, pointless arguments.
look @humptydumpty69 you are more than welcome to post on this thread

The way that you write is indicative of your character. "Quit spamming up MY thread." It is evident that you view this thread as belonging to yourself and being yours. Dissenting opinions and debate are very healthy and important for the community. This thread belongs to the community; the purpose of this thread is to share the experience in which you have tried to enable yourself and the community. Though, I'm glad that I have your permission to participate. I assure you, this post is purely constructive; I'm sure that you appreciate an opportunity for self-examination and reflection. Lastly, I am genuinely appreciative of a John Adams olive branch and effort towards amicability and resolution.
 
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@Daniel Lion,

Yes, which is a great point, and constructive, and the kind of cordial interaction that I prefer to have. Though, I think that the fact that it did not perforate the ear drum is a reason that the raw SC treatment seems more appealing to me personally.
Humpty , hi... as far as I can tell there's no way around the eardrum injection, for FX-322, PRP... it would seem to me that this is the most effective way to get the concoction of choice to go exactly where it's meant to go... in this case the inner ear. I have no scientific background and could be completely wrong... just seems logical to me.

Perhaps in the future nano carriers or the use of magnetics could make the delivery safer, avoiding puncturing the membrane.
 
I thought both the bone marrow adult stem cells and the PRP permeate through the round window into the cochlea during Dr. Shim's IT treatment?
Yup, that's the idea as I understand it, and it seeps down your tubes and you can taste it in your mouth JohnAdams said. The whole idea of it being viscous enough to stay there in the inner ear and work its magic is one of the benefits of spinning the blood, or byproducts of using the centrifuge, as I understand it.

I think if perhaps Dr. Shim had jumped from John's $9K to perhaps $12K or $14K, that might have been a better business move, and a bit easier for people on the forum to swallow. Having said that, I'm always wrong when it comes to business, and business ventures.
 
@Daniel Lion,

I'm no expert on the matter either Daniel, though I can recall that fellow Ed benefitting from interarticular injections, though I believe that he had some interesting causation, differing a bit from our general community. And the intramuscular injections that ATEOS received were very effective in his personal case. I have read decent claims about intrathecal administration, though I haven't read anecdotal accounts or legitimate data on its efficacy.
Also, when you are comparing these other therapies to PRP, I think we must note that PRP is potentially 72 or more injections, though the PRP does aid in healing. Then you have the standard injections which are only once, or a handful of times at most. Which is less risk? I can't answer that, but I would speculate that the risk is similar. 72 injections aided by a serum comprised of wonderful healing properties, and then one or more injections left to heal by the body? I imagine that age is a factor, as well as general robustness of the subject's body. Also, if there are autologous aspects in that serum, again we have to consider the general robustness of the source of extraction. Elderly people could fair far worse than youth.

And yes Daniel, bring on the Sci-Fi, it is about time.
 
PRP and Stem Cells are the sci-fi... two forum members as you know have tried the procedure... we are living in a sci-fi reality in terms of Orwellian marvel and doom...

Having said that, PRP definitely works for some people and some traumas. I have come to believe this, but it would appear that no person or institution in the USA, or Western Europe has embarked on this for ear regeneration, or an anti-inflammatory therapy, as far as I know. PRP in cosmetic surgery and for athletes is common place.

It's not common place in ears... Why? Is it as simple as the West not having caught up yet with stem cells and PRP?

I am trying to read through documents posted on this thread. It's time consuming and it's definitely out of my realm of experience, but I try. Some studies that have been posted I see as compelling and others I have difficulty seeing some of the correlations, as opposed to implications... so yeah... I am actually confident that John Adams's audiogram will be sweet and show real gains... I am just an observer and a friend, rooting for JohnAdams, GlennAZ, and everybody who suffers on this forum. I know everybody agrees. Same team.
 
Writing @Daniel Lion about intrathecal injections has reminded me of a supplement that I have taken for autoimmunity and my hearing called "Stem Cell Activators". I don't believe that I have shared this information with the community before, but this is a supplement with which I have tried to ease in to the idea of stem cell therapy. I learned about it from a book on both PRP and SC by a naturopath named "Joseph Christiano". His book is titled, "Stem Cell Revolution".

The book is very accessible to the layman, it contains both scientific citations and a narrative of anecdotal accounts.

I will try my best to explain what I know about this supplement, and forgive me, it is possible that I state inaccuracies:

Stem Cell Activators are synthesized regulatory peptide hormones. As I understand it, whenever the body is injured and in need of repair, every tissue has a specific regulatory peptide hormone that it excretes in order to prompt naturally occurring autologous stem cells to travel to that site and then to repair that tissue. So the proprietors of this product have isolated those specific, naturally occurring, and individual peptide chains, identified their composition, and then reproduced them to be ingested in microdoses. Evidently this substance is so small that they call it "Nanotechnology," and it seemlessly passes into the bloodstream when taken sublingually or is absorbed through the stomach lining.

I was taking Stem Cell Activators for my autoimmune condition because of the claims that stem cells are wonderfully immunomodulatory. I can say definitively that the immune version of this supplement brought me from a mildly/moderately bedridden state to decently active in a few months. But why I am making this post is regarding the ears. I spoke to the company representatives extensively, and they told me that their serum associated with the calling of stem cells to the spinal cord and central nervous system has been noted by customers to reduce their tinnitus. Since this correlated to the concepts that I had read regarding clinics utilizing intrathecal SC injections, I decided to give this supplement a try.

Concerning my ears, I noticed very little change aside from a couple reactions. I had the sensation of an ear reset that was so deep and long, I went to sleep in a panic because I thought that I couldn't hear. The volume went way down and was distorted, though when I awoke, my hearing was much improved regarding the textures of sound that I could discern. I can't say that I held on to this progress long, because I seem to nearly enjoy reinjuring my ears via noise exposure; though I can say that I experienced the aforementioned sensation a handful of times, each time followed by slightly better perception of texture and overtones. Unfortunately and ultimately, I had no better stamina towards volume or noise.

I would like to state that I noticed not 1 negative side effect, and the distributor claims that they have never been made aware of a side effect other than mild nausea. The worst that has happened is no efficacy. But I rationalized this as an affordable means of experimenting with SC, and I told myself that if I experienced changes, perhaps I would go on to attempt an actual procedure. What I experienced was at least enough to make me curious about a SC procedure regarding my ears, and absolutely enough to make me optimistic about immunomodulatory effiicacy.

For those who are interested, the website is listed as the following:

https://www.bodyredesigning.com/index.php?l=product_list&c=21

Evidently there are other distributors of Stem Cell Activators, but I am not aware of those companies. The labeling of these products and advertising could be interpreted as unprofessional, and I'd agree, but try not to be influenced by poor graphics and labeling. They recommend 6-8 months of usage for a therapy cycle. Some people never stop taking the supplement in fear that symptoms will return. The cost is about 50 USD for just under 1 month of dosage. I could elaborate on dosage further if there is interest. I have heard about potential difficulties in customs with Canada, as the vendor that I have listed is USA based; though I believe the Canadian post was striking at that time, so I'm not sure if customs had an issue with this specific product, or if the post was just crazy out of whack. Ultimately the package was returned to the sender.

I would like to clarify that I am not recommending that anyone try this product; the purpose of my post is simply to give people who are curious or considering spending thousands of dollars an affordable option of something far less potent in order to potentially help them decide if SC is actually right for them as individuals with very subjective maladies.
 
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Writing @Daniel Lion about intrathecal injections has reminded me of a supplement that I have taken for autoimmunity and my hearing called "Stem Cell Activators". I don't believe that I have shared this information with the community before, but this is a supplement with which I have tried to ease in to the idea of stem cell therapy. I learned about it from a book on both PRP and SC by a naturopath named "Joseph Christiano". His book is titled, "Stem Cell Revolution".

The book is very accessible to the layman, it contains both scientific citations and a narrative of anecdotal accounts.

I will try my best to explain what I know about this supplement, and forgive me, it is possible that I state inaccuracies:

Stem Cell Activators are synthesized regulatory peptide hormones. As I understand it, whenever the body is injured and in need of repair, every tissue has a specific regulatory peptide hormone that it excretes in order to prompt naturally occurring autologous stem cells to travel to that site and then to repair that tissue. So the proprietors of this product have isolated those specific, naturally occurring, and individual peptide chains, identified their composition, and then reproduced them to be ingested in microdoses. Evidently this substance is so small that they call it "Nanotechnology," and it seemlessly passes into the bloodstream when taken sublingually or is absorbed through the stomach lining.

I was taking Stem Cell Activators for my autoimmune condition because of the claims that stem cells are wonderfully immunomodulatory. I can say definitively that the immune version of this supplement brought me from a mildly/moderately bedridden state to decently active in a few months. But why I am making this post is regarding the ears. I spoke to the company representatives extensively, and they told me that their serum associated with the calling of stem cells to the spinal cord and central nervous system has been noted by customers to reduce their tinnitus. Since this correlated to the concepts that I had read regarding clinics utilizing intrathecal SC injections, I decided to give this supplement a try.

Concerning my ears, I noticed very little change aside from a couple reactions. I had the sensation of an ear reset that was so deep and long, I went to sleep in a panic because I thought that I couldn't hear. The volume went way down and was distorted, though when I awoke, my hearing was much improved regarding the textures of sound that I could discern. I can't say that I held on to this progress long, because I seem to nearly enjoy reinjuring my ears via noise exposure; though I can say that I experienced the aforementioned sensation a handful of times, each time followed by slightly better perception of texture and overtones. Unfortunately and ultimately, I had no better stamina towards volume or noise.

I would like to state that I noticed not 1 negative side effect, and the distributor claims that they have never been made aware of a side effect other than mild nausea. The worst that has happened is no efficacy. But I rationalized this as an affordable means of experimenting with SC, and I told myself that if I experienced changes, perhaps I would go on to attempt an actual procedure. What I experienced was at least enough to make me curious about a SC procedure regarding my ears, and absolutely enough to make me optimistic about immunomodulatory effiicacy.

For those who are interested, the website is listed as the following:

https://www.bodyredesigning.com/index.php?l=product_list&c=21

Evidently there are other distributors of Stem Cell Activators, but I am not aware of those companies. The labeling of these products and advertising could be interpreted as unprofessional, and I'd agree, but try not to be influenced by poor graphics and labeling. They recommend 6-8 months of usage for a therapy cycle. Some people never stop taking the supplement in fear that symptoms will return. The cost is about 50 USD for just under 1 month of dosage. I could elaborate on dosage further if there is interest. I have heard about potential difficulties in customs with Canada, as the vendor that I have listed is USA based; though I believe the Canadian post was striking at that time, so I'm not sure if customs had an issue with this specific product, or if the post was just crazy out of whack. Ultimately the package was returned to the sender.

I would like to clarify that I am not recommending that anyone try this product; the purpose of my post is simply to give people who are curious or considering spending thousands of dollars an affordable option of something far less potent in order to potentially help them decide if SC is actually right for them as individuals with very subjective maladies.
Supplements...? I appreciate what you said about peptide hormones, but the rest was a digression. I, we, do it all the time, no offense intended. We are all trying to figure out how to get better. In this case, it's 2 people's experience with PRP, one for NIHL and the other with bad hearing from birth as I understand it.
 
The way that you write is indicative of your character.
Well thanks for making this thread go totally off topic and transforming it into a dissection of my character.
I never asked for a psychotherapist, but since you're taking on the role, am I going to get a bill?
 
I haven't had anything negative from Dr Shims treatment. The only thing negative is it's not healing me fast enough.

Although I got 7 bone marrow stabs, I only got about 50-55 injections. The first two days were only 2 injections each day, but then the pace went up to 4-6 per day.
I really didn't watch what Dr Shim and his nurses were doing. Most of the time, my eyes were closed, and I was trying to stay in my happy place. I didn't feel it would help to look at his bloody syringes, everything and watch too.

But I can tell you, being 65, and I'm nothing close to being a frail old man, there was nothing negative. My eardrums healed excellent. It probably is very helpful that Dr Shim is very skilled and knows what he's doing. I got 4-6 injections on the last Sat, and by Sun evening I was at 35000 feet heading back to Phnx.
Actually, I did notice something. My eutuscian tubes were open and adjusting to the changing altitude the easiest ever in my life.
I don't think there will be problems for me or anyone else with Dr Shins PRP. I'm not trying to sell his services. I'm giving my opinion.
 
I'm not trying to sell his services. I'm giving my opinion.

I get the feeling that some people are furious that I've tried this and given a good report and now you've tried it and are scraping the bottom of the barrel to play chicken little. I bet these same people agree with the the saying "my body my choice".

Seriously, there are people or a person that have created accounts only to get on this thread to make posts accusing Dr. Shim of defrauding them of thousands of dollars through Western Union. For some reason tthey have made up their mind that this is some kind of dangerous threat and are doing what they can to spread fear and disinformation about it.

What about the injections? Yes there is a risk involved with that. Go take your fear mongering to the fx-322 thread because that's going to be an injection too.
 
I want to point out that I contacted Dr. Shim in early December and @JohnAdams in early January.
I visited stem cell clinic regarding MSCs and PRP around the time @JohnAdams went to Korea, before he reported any results from his treatment. In early January I also had a consultation with neuroENT who did intratympanic stem cells before in Russia. There's also a doctor in Ukraine who uses stem cells to restore hearing.

There has been no pressure from either John or Dr. Shim. I believe they are both good people who want to help others. I decided to take out a loan, because my situation was extremely bad and I knew that it started, because of temporary hearing loss in the left ear. Even though according to audiograms hearing fully recovered it was obvious that there was some hidden damage (probably cochlear synaptopathy, because OAE and DPOAE didn't report any abnormalities meaning hearing cells weren't damaged).
I did my own research and consulted with John about it. Before you decide to do anything you need to do your own research and decide if it has potential to work in your case.
I'm convinced that bone marrow derived MSCs and growth factors can restore hearing loss and there are studies and documentation available online regarding this.

In fact there's a drug that's being developed at Massachusetts Eye and Ear by Charles Liberman, Sharon Kujawa and Albert Edge (who's one of co founders of Audion therapeutics) that is based on growth factors and the research is being funded by United States Department of Defense.

https://patents.google.com/patent/US20190022101A1/en

Methods of treating or reducing the risk of developing hidden hearing loss by administering a small molecule Trk agonists (e.g., amitriptyline, imipramine, LM 22A4 (N,N′,N″Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide), 7, 8-dihydroxyflavone (DHF), 7,8,3′-Trihydroxyflavone (THF), Mab2256, neurotrophin-4 (NT-4), neurotrophin-3 (NT-3), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), N-acetylserotonin, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide (HIOC), deoxygedunin, LM-22A4, or tricyclic dimeric peptide 6 (TDP6)).

  • FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
  • [0002]
    This invention was made with Government support under Grant Nos. RO1 DC08577, RO1 DC007174, RO1 DC0188, P30 DC05209, awarded by the National Institutes of Health and Grant No. W81XWH-15-0103 awarded by the Department of Defense. The Government has certain rights in the invention.

@humptydumpty69 @kelpiemsp @GlennAz @GSC @7Thunder's
Did you go through with the procedure?
 
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