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It's a complex subject but it means that the problem you have is inoculating the rest of your brain against the action which will solve the problem. An example would be depression: The best treatment (or one of the best) for depression is intensive exercise but guess what...the last thing you...

I agree with Michael Leigh. If your T seems to be getting louder and you haven't been exposed to a new acoustic trauma then it's your perception of T which is getting worse and it's most likely because you're focusing on it more (you're conscious mind is focusing your unconscious mind on it) or...

Habituation comes when you stop caring about your T. When you stop caring then there is no emotional valence to the signal and thus your amygdala stops attaching emotional "weighting" to it. The signal which is being received by the basolateral nucleus is shunted through to the central nucleus...

You're confusing getting louder (a person's own objective criteria based on its perception without further damage to the cochlea). With "getting worse" (damaging the cochlea more through exposure to further loud noise).

http://nootriment.com/gaba-agonist/

Bear in mind; when the fight or flight emotional response is hitting your pre-frontal cortex at the same time it's also receiving feedback from your body on your physiological state (heart rate, respiration, cortisol levels, adrenaline levels). If your physiological state isn't in keeping with...

If you don't worry about it then it gets better that's why habituation happens. If you do worry about it it takes longer to become habituated. If you worry about it a lot and obsess about it then it gets worse. It doesn't actually get louder it's just that you make a bigger deal about it in your...

Danny, in the article COX2 is mentioned. In your research have you come across any information regarding either COX or LOX as being a contributor to Tinnitus type neuro excitatory behaviours? The reason I ask is there are quite a few proven natural COX and LOX inhibitors in use at the moment...

Anxiety doesn't actually make your T louder it just makes it more noticeable, there's a big difference. Have you ever cut yourself and not noticed until you see the blood and as soon as you do it's starts hurting? It's the same principle. The Tinnitus/pain was always there but it's the paying...

Alas, thinking about something as in visualising or listening for something can create changes in the brains neural architecture. It's like holding a picture in your minds eye, when you do so the unconscious mind finds it difficult to separate what's real from what's not. That's why visualising...

Valeri, you don't have to live like this forever, it's impossible. Since I first got T I have read every single scholarly article on it and it's treatment. Over the last 6 month I can't keep up, the amount of research now is absolutely enormous and the reason being whoever finds a cure will most...

Great post. The cognitive mechanics you're describing ties in with one of the hot topics in theory of consciousness research, namely "global workspace theory". http://en.wikipedia.org/wiki/Global_Workspace_Theory. The conscious mind has to deal with a host of signals from the unconscious mind...

Brilliant post, fake it till you make it then (eventually) you're not faking anymore. You're not actually lying to yourself, you're deciding whats true and resetting your mind accordingly.

That would make your tinnitus worse as you're ascribing huge emotional content to the sound. If anyone feels suicidal then they need professional help. It's a permanent solution to a temporary problem. Nearly everyone who gets tinnitus feels depressed about it at the time, but when you...

The more you think about it, the more important it becomes to you and the harder it is to ignore it. The conscious mind inhibits emotional responses from you unconscious mind when it realises they aren't of any importance to your survival or well being or they might get you into trouble by...

When I first got to see an ENT consultant who actually knew a lot about tinnitus they showed me the notch in my audiogram and explained that this area and it's derived frequencies were responsible for my T, due to the lack of signals reaching that particular band of neurons in my auditory...

It's not the physical aspect of keeping busy which alleviates your T it's the mental aspect. Lots of things vie for your attention every second of the day (some researchers speculate there are over 10,000 bits of information hitting your unconscious mind every second; everything from the levels...

Yes you will be fine in time and yes there will be a day when you don't care about it anymore. The answer is in your post: "I began to listen to it again". Listening is an active process, your unconscious mind hears everything going on around but unless it's of importance, it doesn't inform...

A very good post, and within it the core of habituation. Neurons which fire together wire together, paying attention to your T (which is what happens when you have an emotional connection to a stimulus) mylenates the axons and dendrites of the neurons firing in a particular sequence (basically...

Indeed, there's even a name for it... http://en.wikipedia.org/wiki/Confirmation_bias#In_physical_and_mental_health Which if you're not objective can lead to this... http://en.wikipedia.org/wiki/Affect_heuristic And eventually create this situation...

Indeed, Tinnitus perception is routed to the pre frontal cortex when the amygdala is roused by the signal and attaches emotional salience to it. However...being happy depresses the amygdala's activity as you can't feel two opposing moods at the same time, other brain areas throw it off the...

"Ninety nine problems but T ain't one"

Here's some of the latest links (2014) I found on Google Scholar about LLLT and it efficacy as a treatment for hearing loss. http://oto.sagepub.com/content/151/1_suppl/P212.2.short http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1840622...

It's totally weird how Tinnitus works. I don't think we will know for sure how it's perception can be explained until we have a working model of a "theory of consciousness", and that's years in the future. It always reminds me of the Schrodingers cat business where the cat is both dead and...

Yes it would. Hyperacusis isn't actually super sensitive hearing like Superman has, were you can hear a leaf falling out of a tree at a 100 yards. Your hearing threshold is the same, but your limbic system is "priming" your pre-frontal cortex with negative emotion 300ms before the actual sound...

Yes faking is enough because eventually you're not faking: It's true. Your unconscious mind is like a horse that you (your conscious mind) rides to get wherever it's going. Sometimes the horse (unconscious) and you (conscious) disagree on where you are going and in that case the horse wins as...

You're exactly right. Although the model shown simplifies the concept a fair bit [ The Auditory Cortex also has a feedback loop to the MGN, otherwise asynchronous neurons firing in the auditory cortex area and creating the phantom T sound, would never reach the amygdala] it posits the conjecture...

You're welcome. When I first had tinnitus it drove me round the bend but the turn in the road happened when I realised why it bothered me. It's like a weight off the shoulders. Sort of like having an annoying squeak in your car then all of a sudden discovering what caused it. Even if you just...

Here's a good link explaining how the brain filters out tinnitus after habituation has occurred. http://www.cell.com/action/showImagesData?pii=S0896-6273%2810%2900325-9 Notice the sentence: "The same signal is directed in parallel via the amygdala to the subcallosal area (which includes...

It's a major gain mechanism to increase the accuracy of neuronal responsiveness. By balancing the excitation drive with inhibiting inputs it increases the range of excitation that the neuron can work with. Think of it like the brakes and the accelerator of a car. You can slow down by easing off...

Thanks for that link Sjoerd. Have a look at this one: http://www.sciencedirect.com/science/article/pii/S0896627310003259 especially the paragraph on: Paralimbic Structures as Part of an Intrinsic Noise-Cancellation System "NAc" is the Nucleus Accumbens which is the part of the brain...

The science behind it seems sound enough; Page 10 on this link is very interesting... http://spdfoundation.net/pdf/dodds_synthesis.pdf The latest research into the cause of T is that; Once a specific frequency isn't detected by the auditory cortex then the requisite neurons involved in...

If it is a neuronal malfunction you have more chance of it healing than if it's your cochlea. The brain is very plastic and remaps itself every time you learn something new. People who lose their sight due to eye injury experience huge plasticity into their occipital cortex.

My optimism is getting the better of me haha. My logic is that there are a lot of people from the UK on this forum who would jump at a chance on this trial yet we have no word from anyone at all? I appreciate that a lot of the trialees will have been referred or informed about it by their GP...

If you're not showing any hearing loss then it's a bit of a puzzle. Your auditory cortex may have remapped around temporary damage with adjacent zones taking over the specific frequency recognition remit of the area which was starved of input. The neurons in the zero sum input area can go into...

No news is good news, considering what a moneyspinner this could be if it's successful, I'm not surprised it's being kept wire tight. If there are people from TT involved in the trial they will have signed strict non disclosure agreements. If you were on it and it was working would you risk...

The reason I'm mentioning it is somewhat anecdotal but it does tie in with my own research into a limbic relevance to T. My tinnitus is only in one ear (the right one) and my other ear is fine. I can calibrate the actual level of my tinnitus by playing a tone of the same frequency to my good...

Here's a link quantifying the prevalance of tinnitus as a side effect on people taking Keppra as of Nov 28th 2014 http://www.ehealthme.com/ds/keppra/tinnitus Bear in mind it's not a random sample of the population and only involves patients suffering from epilepsy. This could skew the sample as...

Verbalise what your're thinking and do it in the mirror. First using the Word "I" and then in the second person using the word "You're" Very important: Make eye contact with your self and jump from eye to eye each affirmation. The reason is that your eyes make movements called saccades all the...

It's privately funded but it's biggest investors are. SV Life Sciences http://www.svlsa.com/ Imperial innovations http://www.imperialinnovations.co.uk/ Pfizer venture investments http://www.pfizer.com/partnering/areas_of_interest/venture_investments Do we have a financial analyst on TT anywhere?

There's nothing showing any results on the Clinical trails register yet https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2014-002179-27 Bear in mind it's a double blind placebo criteria study and these things take time. The first indicator of success will be a huge...

Grapefruit juice interacts with some calcium channel blockers and is known to increase the blood levels of certain medications. I guess if they're doing blood sampling to check for metabolites to see how your liver is dealing with the dosage they don't want it being skewed with it being a trial.

The pre-frontal cortex (your conscious mind) does mediate your emotional mind but it's a slow drip drip process of applying very gentle pressure to it; over time though it does add up. The trick is to tailgate your acceptance on to a positive emotion you may be feeling at the time. Strong...

Anything stressful makes T worse in that your perception of it is worse. The volume is the same but the relevance of it is increased. "Stress" from a cognitive stand point is actually information from your senses which has an emotional value linked to it. The culprit is the limbic system of the...

Habituation works by your brain not caring about the sound. Everyone has what's called a global workspace where information is presented to the conscious mind for evaluation by the unconscious. It's the interaction of this information which creates your sense of "I" Eventually tinnitus doesn't...

Dr Charlie. Do you think that the habituation of tinnitus works on a similar mechanism to the therapeutic method of desensitisation used in the treatment of phobias? The reason I'm asking is because; whilst desensitisation works from a slow but gentle fear mediation perspective it also...

This is very interesting. As far as I'm aware, the RVPFC acts as a sort of mediator of the threat response from the amygdala once it has reached the Dorsal Anterior Cingulate Cortex (the DACC informs the conscious mind how much to be concerned about something). The exact mechanism is unknown...

An interesting perspective. Reminds me of the famous scene in Lawrence of Arabia, where Lawrence lets a match burn down in his fingers without flinching. One of his men tries to do the same thing and burns himself and lets out a yelp of pain exclaiming "it hurts!". Upon being asked "what's the...

Hi Melanie, when I was exactly your age I had an empty air rifle fired directly in my ear which did burst my eardrum and give me horrendous T which resolved itself after about a month, gradually abating over the weeks. I told my ENT specialist about it and would the same thing happen again with...

Dr Charlie, would it be possible to speed up the habituation process of tinnitus by consciously focusing upon it during periods of extreme relaxation? I'm wondering if the neural association of T with periods of very low limbic arousal, might in theory place it in the mental box of "safe to...

Hi everyone. I've had the big T for 3 years now due two two acoustic traumas at work in my right ear -left is fine- in my job as an Engineer. Just had an MIR scan at my local hospital in case it was something serious but given the all clear on that front thank heavens ,but now in limbo as my Doc...