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Because it did not have a meaningful clinical difference for me. It was great experience for me however. Are you new to Tinnitus Talk? It’s not always so positive - people are struggling, people are depressed, I don’t have to tell you how hard tinnitus is. P.S. Apply some nuances to your...

Mate, don’t bother with this stuff. I did stem MSC cells in China 4 years ago. I’m fairly sure my story is somewhere. Over 4 IVs over the space of 2 weeks. Anyway, apart from having my bank drained and a little holiday - it was a waste of time. I eventually became friends with some of the...

I would give it a try - it didn’t help my tinnitus much from memory, but it did give me some great benefits in the gym and with sex ha. I had no troubles getting off it when I wanted to stop. Like all these drugs, they can make you feel like you’re in a bit of a daze and tired initially. I...

This does not help. Others and myself has tried for a while. Good luck!

I might offer some clinical advice as a pharmacist. Xanax is not “milder” per say and has similar therapeutic index or potency to Klonopin. Realistically why they are both benzodiazepines, they have different indications for conditions due to their different onset of actions and effective half...

The clinical trials... like all medicines and devices. They can give you an ideal of the correctly indicated patient and the probability of a clinically significant improvement.

Which is why I’m surprised so many people are already handing over cash lol. Apart from a hypothesis and a few anecdotal reports it may be as clinically beneficial as ear candling!

No. The use of systemic corticosteroids is ill advised unless absolutely necessary.

You have a history of exposing yourself to loud events according to your post and getting tinnitus again. May I ask why you continually expose yourself to this?

Bingo! The concern sometimes is with these clinical studies... Is 7 points or more improvement in THI actually a difference patients would notice...

I didn’t read the paper, I was just replying to what you said and clarifying the difference between clinical significance and statistical significance. Ideally it would be both! But the authors should not mistake the difference regardless.

It’s related to a predetermined percentage of improvement of which a patient would require to notice or see an important in their symptoms. However it's not always exactly clear what the level of improvement required is deemed to be clinically significant especially with something such as...

You don’t need the internet to tell you the answer. Your post has it.

They all have mild and tolerable side effects in the lit. Longer half life ones are less addictive is all. Eg. Klonopin Take what your doc gives you. Don’t ask people on the internet. They are used by millions of people around the world safety. Don’t demonise an amazing class of drug, just...

I'm fairly sure I commented on one of the other Memantine threads... I took this for about a month. It's probably one of the strongest drugs I tried (I tried a lot! Maybe Pramipexole was harder..) as far as other side effects, and certainly makes you feel like you're on another planet aha. As...

Actually tinnitus volume and distress are not always inextricably linked. Distress/handicap reduction is generally accepted as the best indicator for treatment efficacy. However, of course members (myself included) of this forum want to see a reduction in our tinnitus volume which would give...

No AD is indicated for tinnitus. It's pot luck based upon anecdotal reports.

A robust and well controlled clinical study with a larger well representative sample size with logical co primary end points will always be more indicative than anecdotal responses on a forum. It's one of the reasons people end up down rabbit holes on this forum as one person reports...

Certainly not the most reliable source, but certainly would give hope if people are responding to the treatment on Tinnitus Talk.

Who says this? Alcohol or caffeine is not Ototoxic in that it causes physical damage to your ears. It may however irritate your tinnitus however!

Not at all. The fact the flu can make your tinnitus louder and the risk of ear infections resulting from that means you want to minimise the risk.

How many hours a day do you spend at the gym, Steve? haha

And ENT would tell you why but it’s likely ETD. Try a nasal spray to see if it helps

Nope. You should be able to pop your ears gently.

Get a robot vac so it cleans your house when you’re out.

That’s the one :) My mistake, it wasn’t the latest episode.

I recommend eveybody checkout the latest ATA podcast with Susan

Myself and a few others have as well. There is another thread about all the members whom have had MSC. I’ve talked about my experience in a few threads around too.

8500

Please be careful :) All the best.

They are probably so high on drugs with their careers they wouldn’t even notice.

I suggest that you do some research. Tinnitus or not, people should be wearing ear plugs at concerts. Even if yours is not a result of hearing damage, it very much could end up that way. Just because yours started from benzodiazepines doesn’t mean you don’t have hearing loss, Tinnitus is a...

Please don’t feel bad for being down! Lots of hugs! Xoxo

A lot of ADs have that the first few days but that improves. In my experience that nausea is quite common but improves with time. Nortriptyline, and Mirtazapine is considered pretty safe. Zoloft is very popular too. I’ve tried Valdoxan as well with limited benefits but it’s safe and has...

Thank you! God bless

Great you wore earplugs. If you want to enjoy your music get some professional musician plugs or custom so it reduces the volume but doesn’t reduce how beautiful music can be. That way you don’t need to remove them. Take regular breaks and don’t sit near the front. Enjoy!

Have you seen a doctor about your sadness sir? It might be worth taking something to help:)

Yep, and they are antidotal internet reports which are impossible to verify.

FYI. In my experience this is all negotiable:)

They can induce MSC to a pluripotent form. Making the MSC becoming the type of cell you need it too is another level. Playing God isn’t easy!

For it to be considered clinically relevant it would be a costly outlay and require many participants. There is a paper regarding a single case of embryonic stem cells causing cancer, again that’s not clinically relevant but still a scary possibility nonetheless. You’re asking questions nobody...

No references, what is tinnitus123? You may as well be reading what somebody posted on their Facebook. See above for my thoughts on that author. He should best stick to forestry, not anything medical related.

I wish there was a sticky or something on TT about that site. The author has no medical or pharmaceutical qualifications. Infact they are in forestry! Why he writes about audiology matters is beyond me!

Most certainly not. Always check your sources of who is telling you its ototoxic. I have taken it for years since my Tinnitus; it maybe even makes it more quiet! Panadol is very gentle.

And myself. 150M Umbilical delivered via IV.

That is actually quite a fair bit. Every clinic seems to have different recommendations on what they wish to inject (with the price getting higher the more they inject).

You're confusing stem cell potency and the DNA they are deprived from. Stem cell potency is their capability to become different types of cells. Pluripotent (usually embryonic) can pretty much become any type of cell in your body so thats potentially why in regards to the paper you're...

Which papers? The difference between cord blood Msc is they are donated, adipose are your own fat. The paper I know of talks about a case of pluripotent embryonic causing cancer or believed to.

And expensive!!! Ha

That was be a big undertaking for such a clinical trial to exist and also be clinically reliable and credible, so not that I know of. Cancer is quite common so a causal link would require thousands of applicants. So no, and if it did it would mostly be antidotal and a scientific hypothesis.

You are confusing yourself. MSC can be deprived from many types of DNA including cord blood and adipose which are all multipotent by default in that their potential to become certain types of cells is limited. Pluripotent is a type of MSC that can become all type of cells within the body and...

Feel free to reach out if you need anything. All the best.

150 million. 3x IV treatments. No, not LP or Intratympanic.

I believe so yes. I was a musician for years and it started the day after being in a club. Not in my experience, no. I thought so initially but that’s likely a result of the corticosteroid injection to avoid rejection (not required if they are Adipose) of the MSC when the IV is inserted. Time...

Yup. China. Mostly sales fluff from the consultant, but it’s believed they can reduce inflammation so seem to help with issues such as arthritis. I used to get RSI in my wrist and it’s gone since MSC. The stem cells you would be injected with are not pluripotent (embryonic etc) so can’t...

Very few drugs are actually ototoxic, in that they actually cause physical damage to ears. Sure many will ascerbate Tinnitus, but that often stops on succession of the medication. As for the hearing loss website. Using that website as a reference point is I’ll advised as the author has no...

- 150 million embryonic mesenchymal stem cells - 2 weeks for treatment - no side effects for me, but your results may vary :)