PetitGarsTimide
Member
- Jan 6, 2018
- 225
- Tinnitus Since
- 2016
- Cause of Tinnitus
- Dumb teenager who listened to loud music everytime
My Posting Place
- Thread starter threefirefour
- Start date
Member
Agreed. Probably a very long time, in fact. I shouldn't get too excited.
At the same time at least this shows that there are companies who see past the 250 - 8000 hz Stone Age.
i seriously believe MPP will help raise awareness which can speed up research if more people become aware of the issues
Oh. I couldn't find any master threads tracking Otonomy, just a bunch of disparate ones.
In any case, thankfully they are definitely an active company as their website lists Phase I/II trials for both a hidden hearing loss therapy and a tinnitus therapy (two separate compounds) both to begin in the first half of 2019.
What I don't understand is that if curing hearing loss will also solve tinnitus why are there seperate trials, they are going on a false hyothesis that tinnitus has to do with NMDA and is based in the inner ear. Not that tinnitus is centralized in the brain from hearing loss.
Blocking NMDA helps prevent tinnitus, but it is not the root cause of tinnitus. By blockign NMDA it prevents more hearing loss. I am upset that an incorrect model of tinnitus exist and is still being used.
https://www.ncbi.nlm.nih.gov/pubmed/11423221
https://www.ncbi.nlm.nih.gov/pubmed/11423221
I agree. But they could intentionally be creating an overlap should one of the two fail. Also, the HL cure definitely may not work completely, so the tinnitus therapy could still be relevant. Finally, although I too am of the opinion that nonsomatic T is almost always caused by some type of HL, I believe there are some cases where it is not (e.g. TBI, where the cranial auditory system is affected directly).
So unfortunately imho your statement is based on a viewpoint that is too optimistic
What is NDMA and what is the NDMA hypothesis?
BRB I have to challenge the scientist at Auris Medical that have a false model of tinnitus, though they are right about blocking NDMA to prevent further damage.
I agree. But they could intentionally be creating an overlap should one of the two fail. Also, the HL cure definitely may not work completely, so the tinnitus therapy could still be relevant. Finally, although I too am of the opinion that nonsomatic T is almost always caused by some type of HL, I believe there are some cases where it is not (e.g. TBI, where the cranial auditory system is affected directly).
So unfortunately imho your statement is based on a viewpoint that is too optimistic
What is NDMA and what is the NDMA hypothesis?
They are right about everything except the part about "aberrant excitation of the audiotory nerve that is preceived as tinnitus" The auditory nerve itself is NOT generating the tinnitus signal, it's in the brain even in acute phases.
By preventing more hair cell damage they are theraputicizing the tinnitus by preventing hearing loss.
The central gain model is here I posted it a million times
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208401/
It's a shame there trial failed though, it would have helped acute sufferers
They are wrong about what leads to tinnitus, but they do have an effective way of treating acute tinnitus simply by preventing more hearing loss.
I just worry OTO-313 and OTO-413 will only be acute and the normies will flood it with "We don't know the acute phase BS" just like they did at Auris Medical trial
Thank you.
I too believe in this central gain hypothesis, and I agree that Occam's Razor (i.e. the simplest / most minimal explanation is preferred) would dictate that this is the cause of tinnitus in the acute phase as well. That said, I'm not sure how applicable Occam's Razor is here considering as there do seem to be so many factors involved in tinnitus, as evidenced by the fact that some with HL have no tinnitus, and that tinnitus goes away after some time for some people.
But at this point I'm kinda out of my league already lol. Although tbh the researchers apparently don't understand all that much either, so why is my/our opinion worth much less than theirs. Also confused as to why Keyzilen was only proposed for acute phase.
https://www.nature.com/articles/srep24907
24 hours after an exposure that causes an immediate loss of up to 50% loss of synapses in the cochlear basal region, can regenerate pre- and post-synaptic elements at the hair cell / cochlear nerve interface. This synaptic regeneration, as documented by confocal microscopy of immunostained cochlear sensory epithelia, was coupled with a corresponding functional recovery, as seen in the suprathreshold amplitude of auditory brainstem response Wave 1. Cochlear delivery of neurotrophins in humans is likely achievable as an office procedure via transtympanic injection, making our results highly significant in a translational context.
Just remember if they say it's an "acute treatment" that in no sense should a MPPer get there hopes up
24 hours after an exposure that causes an immediate loss of up to 50% loss of synapses in the cochlear basal region, can regenerate pre- and post-synaptic elements at the hair cell / cochlear nerve interface. This synaptic regeneration, as documented by confocal microscopy of immunostained cochlear sensory epithelia, was coupled with a corresponding functional recovery, as seen in the suprathreshold amplitude of auditory brainstem response Wave 1. Cochlear delivery of neurotrophins in humans is likely achievable as an office procedure via transtympanic injection, making our results highly significant in a translational context.
Just remember if they say it's an "acute treatment" that in no sense should a MPPer get there hopes up
Auris Medicals attempt to prevent more hearing damage by using NDMA antagonist was only for early phases of tinnitus.
Folks with long term tinnitus assumed it would help them even though Auris Medical clearly stated it would not.
They were in self denial convincing themselves it would help them, despite not understanding the science of how it works.
Same thing now we have normies with Cochlear implants thinking Frequency Theraputics will help them when CI's require destroying parts of the cochlea. Or totally deaf people that don't have any progeintor cells to duplicate.
Frequency Theraputics is to help people with mild/moderate hearing loss.
if your damage is worse almost entirely related to mushy hearing )synapse only damage) it won't be much help.
It would be better if my damaged high frequency hair cells mostly died before Frequencies treatment.
Because Frequency will not repair hair cells with damaged synapses just grow new ones and my problem like actually most people is synapse damage, not actual hair cell death.
https://www.sciencedirect.com/science/article/pii/S0378595516302507
Crazy as it sounds it would hypothetically be a good idea to destroy the damaged hair cells then grow new ones.
I thought about this idea months ago, but didn't want to mention it because it sounds a bit cooky.
Because Frequency will not repair hair cells with damaged synapses just grow new ones and my problem like actually most people is synapse damage, not actual hair cell death.
https://www.sciencedirect.com/science/article/pii/S0378595516302507
Crazy as it sounds it would hypothetically be a good idea to destroy the damaged hair cells then grow new ones.
I thought about this idea months ago, but didn't want to mention it because it sounds a bit cooky.
it's not about hearing above 14,000 hz in my case, I'm okay with my hearing cutting of there. It's about having quality hearing in my high frequencies. High pitch noises shouldn't muffle or be outcompeted by background noise. They should sound sharp and natural.
Also normies would be offended if they found out I was a whiny crybaby that literally spent so much time complaning about hearing distortion that only effects music and noisy enivorments. By normie definition my hearing loss is clinically unconcerning and reactive tinnitus can be habituated too and TTTS isn't even mentioned.
If you thought the cover page was bad, the actual magazine itself is a million times worse.
https://www.ata.org/sites/default/files/TinnitusToday-Spring2018.pdf
https://www.ata.org/sites/default/files/TinnitusToday-Spring2018.pdf
I'm a fucking amateur posing as an expert. Pay no attention that the only thing I am doing is linking science papers about tinnitus, not making my own hypothesis.
if i get something wrong or over exaggerate it is because I am an amateur and not an actual PHD.
Honestly, this was the only gem I found while sifting through the magazine, and it was on complete accident. I was hoping MPP or TT could get name recognition or something, but the general acknowledgement is cool too.
The problem I fret is if we do get mentioned specifically by the ATA is that it would most likely be a scenario where the ATA itself will directly contact the "administrative forces of this Xenforo™ forum which host discussion to abnormal activity in the audiotory regions of the brain" may be directly advised by the ATA that we need to be purged. Rather the "administrative forces of this Xenforo™ forum in which host discussion to abnormal activity in the audiotory regions of the brain" allow MPP to continue to use memes and science advocacy to bring us closer to the cure or the "administrative forces of this Xenforo™ forum in which host discussion about abnormal activity in the audiotory regions of the brain" decides to delete our thread and even block us from the forum is yet to be seen. It really depends of status quo comes before getting people real help. However I'd choose the latter if I was an association with the "administrative forces of this Xenforo™ forum in which host discussion to abnormal activity in the audiotory regions of the brain"
However in the mean time MPP still exist to put damage control on the propaganda
so hooray for us!
Get's Juicy. The Author of that article is Dr. Hubbard, who is a member here. He absolutely targeted the "negative forum" dig at the site, and the "negative users" is probably a direct reference to people who would browse this post.
We made it bois.
I never really blamed CBT as a problem because it seems to have it's roots in therapies outside of tinnitus where it can be very useful, I mainly focused on TRT being a problem. But make no mistake if they value CBT as the equivalent of being cured that's not going to be tolerated by MPP.
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