@Zimichael
I hope you get some positive results once you get your hands on this drug.
Fingers crossed!
@Jay M ...Thanks! Yeah I'm ready to start today after all the research I've done to weigh the risks, but obviously the "Potiga Gods" are not. Oh well, after the gazillion hours, days, weeks, years, I have had this 'charming' affliction, and my age...(creaking and groaning sounds
) I have learned some patience. I think???!!! Hopefully the stuff will ship rapidly from the cold, wet, damp, ever-drizzling land and accelerate in anticipation of sunny California.
Hi Everyone,
It would be interesting to know that once the potassium channels have opened and stay strong for a while, if once off the drug, they will then stay open. Unlike a Benzo which needs continued use. I believe Benryu may have intimated that once this plasticity takes place re potassium channels, it will stay strong, even off the drug. Right? Can anyone comment more on this re plasticity and potassium channels?
Thanks.
@Lisa88 ...This is one of the $50K (Uhhh...now with inflation and Fed stimulus I guess that should be $5o Billion) questions, and is probably the most anticipated and exciting, to my mind, after the fact that the K channels actually do "work" on T....viz. Retigabine/AUT00063.
My personal feeling is that it is very likely brain plasticity will adapt to the new state - or back to the prior pre "bouton boom" damage + Glutamate, that likely caused the problem in the first place. Brain adaption is just a fact and amazing (just look at what happens with stroke patients). Now I realize that with stroke and such there are 're-directions' within undamaged parts of the brain getting worked on and roads traveled that were dusty side streets before getting traffic, but I can't believe there are not "synaptic level" changes going on too, as per this K channel door kicking stuff.
This has been pretty well covered by
@benryu and some of the other posts in this Goliath of a thread and it will take some work to decipher it, but it's there. If you go back, you will find it.
In the end though, the proof is in the pudding. We need to see what happens with this current "experiment" and then ultimately Autifony's lead in the game.
@jazz ...(and others) looking forward to reading your new research posts. Thanks much for consistently good info. This truly is an example to me of the fact that 'more heads mulling a puzzle are better than one' (well as long as Putin isn't one of them...sorry, couldn't resist. Maybe I should say Mugabe, to stick to my experiential roots
).
As an aside, now that I have to sit (not exactly as in 'doing nothing' these days!) and wait for the Potiga, I am going to see if I can dig up some potential counter-measures for "urinary retention" issue with Retigabine. Something that does not work on K ions and such, as this could be a side effect that is more common than many of the other potential ones we could encounter.
@jazz ...You are such an excellent researcher, if you have any great ideas on this, would be very useful to know and please swing my way in Conv. (or here) if you wish to, or have time/inclination.
I intend to ask my doc as well after the dust settles a bit as boy have they been getting an email storm of requests from me...Kinda like all the letters Harry got from 500 directions to get him into Hogwarts! "Owls everywhere" overload.
Getting long post attack again ~ Sorry, this darn coffee...but it is one of the few things I look forward to in a day of "screeching", etc., etc., etc.
Best, Zimichael
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