Suicidal

[PeteJ]

FX-322 is a pipe dream, imho, unless people start leaking it's helped them.

Also, there's so many "types" of tinnitus and causes.

I think a real treatment for loud/severe tinnitus is needed so a regeneration type of treatment is most necessary compared to neuromod type ones because some type of inner ear damage/SNHL is the most likely condition - and regeneration (to repair inner ear) treatment is needed to help the largest group of people and may help others who had other causes to their tinnitus?

Also, that type of tinnitus probably involves most patients/sufferers with the louder tinnitus cases, I am guessing.

 

[weab00]

FX-322 is a pipe dream, imho, unless people start leaking it's helped them.

Also, there's so many "types" of tinnitus and causes.

I think a real treatment for loud/severe tinnitus is needed so a regeneration type of treatment is most necessary compared to neuromod type ones because some type of inner ear damage/SNHL is the most likely condition - and regeneration (to repair inner ear) treatment is needed to help the largest group of people and may help others who had other causes to their tinnitus?

Also, that type of tinnitus probably involves most patients/sufferers with the louder tinnitus cases, I am guessing.

I agree that cochlear regeneration is going to be needed for people with noise-induced tinnitus from broken cochleas. Neuromodulation is more likely to benefit somatic or central nervous system causes. FX-322 and all the other drugs certainly feel very intangible right now and will continue to until we have veritable results on the market. I rest optimistic for the drug though based on the anecdotes and results to date, as well as the indication that restoring some hearing with cochlear implants or hearing aids reduces tinnitus for a lot of people.

 

[GBB]

I agree that cochlear regeneration is going to be needed for people with noise-induced tinnitus from broken cochleas. Neuromodulation is more likely to benefit somatic or central nervous system causes. FX-322 and all the other drugs certainly feel very intangible right now and will continue to until we have veritable results on the market. I rest optimistic for the drug though based on the anecdotes and results to date, as well as the indication that restoring some hearing with cochlear implants or hearing aids reduces tinnitus for a lot of people.

Not trying to be fresh, but what do you guys mean by broken cochleas?

 

[weab00]

Not trying to be fresh, but what do you guys mean by broken cochleas?

I was just being hyperbolic, but assuming tinnitus is caused by damaged OHCs and synapses. @FGG or @serendipity1996 know a lot more than I do.

 

[GBB]

I was just being hyperbolic, but assuming tinnitus is caused by damaged OHCs and synapses. @FGG or @serendipity1996 know a lot more than I do.

Gotcha, just wanted to make sure there weren't even more additional modalities of damage I am unaware of (there most definitely are).

 

[Greg Sacramento]

@lis @FGG and @Chinmoku
Saw your questions above addressed to me.

This is a recent press release summary beyond their research library, advisors and videos that I provided this year. I have read their research library on neuro diseases and pain. Questions are welcome.

VistaGen Reports Positive Preclinical Data Differentiating Mechanism of Action of PH94B from Risk-Ridden Benzodiazepines

 

[Ismael]

I fully understand all the impressions.

I am not someone who talks in vain, as my tinnitus is very severe. In this tortuous life that was different from the previous one, I have searched, I have clung to values that are above my cross.
There are millions of people with insignificant problems in their day to day, they are ridiculous, they will never understand what it is to suffer our loss of silence.

They must find their personal weapons to live, there is always something to fight for, to live for, and also to enjoy despite everything.

A hug and strength (sorry for the translation).

 

[dan]

FX-322 is a pipe dream, imho, unless people start leaking it's helped them.

Also, there's so many "types" of tinnitus and causes.

I think a real treatment for loud/severe tinnitus is needed so a regeneration type of treatment is most necessary compared to neuromod type ones because some type of inner ear damage/SNHL is the most likely condition - and regeneration (to repair inner ear) treatment is needed to help the largest group of people and may help others who had other causes to their tinnitus?

Also, that type of tinnitus probably involves most patients/sufferers with the louder tinnitus cases, I am guessing.

How are you doin' Pete? Any habituation kicking in yet?

 

[dan]

My tinnitus is so loud right now my only outlet is to come here and vent. It's an insane level of volume and I hate it...

Just sit by the mini fridge dude.

 

[GBB]

Just sit by the mini fridge dude.

It quieted significantly since I posted that. On that day it was loud over everything - I was on Prednisone following exposure to a fire alarm.

 

[kamil1364]

Honestly I don't even know how to talk with my mum (I am 18 and still living with my parents). I was with her (she insisted to go with me) to 2 ENTs. After standard <8000 Hz audiometry they told her my tinnitus/dysacusis is caused by TMJ, but I am 99% sure it's noise induced. She just doesn't understand it is caused by lawnmowers ("because your dad used them for longer than you and he's fine") and by headphones ("because your sister also blasts them and she's fine"). I feel really sorry for her. Since my tinnitus onset I've became burden to my family. She sees me walking around like a zombie, totally emotionless. I am not happy with that, but I also don't have energy for pretending everything is okay. Killing myself would leave her devastated, but what choice do I have?

 

[PeteJ]

How are you doin' Pete? Any habituation kicking in yet?

Crappy. No.

Why does tinnitus worsen?

 

[GBB]

Honestly I don't even know how to talk with my mum (I am 18 and still living with my parents). I was with her (she insisted to go with me) to 2 ENTs. After standard <8000 Hz audiometry they told her my tinnitus/dysacusis is caused by TMJ, but I am 99% sure it's noise induced. She just doesn't understand it is caused by lawnmowers ("because your dad used them for longer than you and he's fine") and by headphones ("because your sister also blasts them and she's fine"). I feel really sorry for her. Since my tinnitus onset I've became burden to my family. She sees me walking around like a zombie, totally emotionless. I am not happy with that, but I also don't have energy for pretending everything is okay. Killing myself would leave her devastated, but what choice do I have?

Try to hang in there for 2-3 years - think about the math - you could be cured at 21 and have 70 good years on the other side of that. I know it's hell, but the math makes sense to stick it out.

 

[Matchbox]

It quieted significantly since I posted that. On that day it was loud over everything - I was on Prednisone following exposure to a fire alarm.

Prednisone is playing with fire, made me so much worse off... It temporarily keeps the noise away sure. But it's carpet bombing. I always spiked coming off of it, and left with gorgeous new noises, as the old ones come back (slightly quieter, which would've happened regardless).

 

[dan]

Crappy. No.

Why does tinnitus worsen?

That's the million $ question

 

[dan]

It quieted significantly since I posted that. On that day it was loud over everything - I was on Prednisone following exposure to a fire alarm.

You're recovering nicely.

 

[funeralcry]

The one thing I am grateful for is that death will come someday. Life is pointless. I wish for this painful existence to end.

 

[PeteJ]

That's the million $ question

And the answer????

 

[GBB]

You're recovering nicely.

Eh, dealing with another super loud spike. When I don't have any noise exposure my ears seem to be trending down volume-wise, and then innocuous crap seems to break them even further. No idea where I'll end up.

 

[dan]

Eh, dealing with another super loud spike. When I don't have any noise exposure my ears seem to be trending down volume-wise, and then innocuous crap seems to break them even further. No idea where I'll end up.

What kind of "innocuous" noise for example?

 

[dan]

And the answer????

The answer in your case, perhaps is to stop trying to improve your tinnitus with shopping cart noise... not sure, could be anything...

 

[Bill Bauer]

Eh, dealing with another super loud spike. When I don't have any noise exposure my ears seem to be trending down volume-wise, and then innocuous crap seems to break them even further. No idea where I'll end up.

What happens in any given hour or day is irrelevant. The spikes and the setbacks are completely natural. What Matters is the Monthly trend and the global low. If the monthly trend is for the volume to go down, and the lowest tinnitus volume level keeps getting lower every month or two or 6, then you are in a great shape and will eventually be over tinnitus.

 

[GBB]

What kind of "innocuous" noise for example?

Just dumb stuff - a family member opened an Amazon box in a loud manner by ripping off tape in one quick motion - wouldn't be a problem for 99% of people, for me fleeting tinnitus into big EEEEEE spike. I have earplugs and earmuffs, and I already spent a month alone in a quiet location away from home to give my ears a chance to heal, it's just hard to avoid sound sometimes. Another example would be a family member puncturing the film that seals certain kinds of foods from the grocery store - in this case a container of parmesan cheese - the loud "pop" set me off.

One that got me today, when I close doors in the house I twist the knob all the way left to fully retract the metal piece and let it avoid contact with the door frame, and then slowly let the knob rotate backwards to silently put it in place. A family member closed the door in a normal fashion resulting in a loud click and a spike.

The world is dangerous for me, I'm afraid.

 

[PeteJ]

The answer in your case, perhaps is to stop trying to improve your tinnitus with shopping cart noise... not sure, could be anything...

Huh?!?

I live in a POS apartment building that has frequent fire alarms.

Also, ambulances constantly go around the corner. I can't move though.

I HATE THIS FUCKING COUNTRY AND THE PEOPLE IN IT.

Does anyone wish you could do a murder suicide? I would like to take out certain people who risk making my tinnitus worse. Maybe it did.

I fucking hate this world.

Can I die by making carbon dioxide go in my car? I can't take it anymore.

 

[David Vance]

Maybe we can meet up for mutual support. I'm in Toronto. You?

Still in Toronto? I'm from there and moving back soon!

 

[just1morething]

What happens in any given hour or day is irrelevant. The spikes and the setbacks are completely natural. What Matters is the Monthly trend and the global low. If the monthly trend is for the volume to go down, and the lowest tinnitus volume level keeps getting lower every month or two or 6, then you are in a great shape and will eventually be over tinnitus.

I didn't think anyone got over tinnitus unless it was somatic? That's why treatments are being developed for cochlear damage.

 

[GBB]

I didn't think anyone got over tinnitus unless it was somatic? That's why treatments are being developed for cochlear damage.

Have you spent any time in the Success Stories portion of this site?

 

[dan]

Huh?!?

I live in a POS apartment building that has frequent fire alarms.

Also, ambulances constantly go around the corner. I can't move though.

I HATE THIS FUCKING COUNTRY AND THE PEOPLE IN IT.

Does anyone wish you could do a murder suicide? I would like to take out certain people who risk making my tinnitus worse. Maybe it did.

I fucking hate this world.

Can I die by making carbon dioxide go in my car? I can't take it anymore.

You need to go on disability ASAP and move out of there.
Have you gotten hit by those alarms more than once?

 

[dan]

Just dumb stuff - a family member opened an Amazon box in a loud manner by ripping off tape in one quick motion - wouldn't be a problem for 99% of people, for me fleeting tinnitus into big EEEEEE spike. I have earplugs and earmuffs, and I already spent a month alone in a quiet location away from home to give my ears a chance to heal, it's just hard to avoid sound sometimes. Another example would be a family member puncturing the film that seals certain kinds of foods from the grocery store - in this case a container of parmesan cheese - the loud "pop" set me off.

One that got me today, when I close doors in the house I twist the knob all the way left to fully retract the metal piece and let it avoid contact with the door frame, and then slowly let the knob rotate backwards to silently put it in place. A family member closed the door in a normal fashion resulting in a loud click and a spike.

The world is dangerous for me, I'm afraid.

Ditto on those noise scenarios.

 

[PeteJ]

My Dad passed away last night.

I couldn't visit him because of COVID-19.

At least, his suffering is over. I want my suffering to be over now.