Brivaracetam — KV3.1 Modulator

[Beste]

We waited it for working on KV3.1 but now it is out and it is working on different part of the brain.

What kind of hell is this?

 

[Kyxwz]

We waited it for working on KV3.1 but now it is out and it is working on different part of the brain.

What kind of hell is this?

I don' know but seems to be on market: http://www.briviact.com/

https://en.wikipedia.org/wiki/Brivaracetam

 

[Poyraz]

I don' know but seems to be on market: http://www.briviact.com/

https://en.wikipedia.org/wiki/Brivaracetam

I'd really like to try it but I really don't know if it will be worth doing it since is is not working on the channels we aspected.

 

[swc5150]

It's basically a really potent Keppra, from what I understand. A few of us here tried Keppra, some with success, others with horror stories. Keppra cured what H I had, which was pretty mild to begin with, and I think calmed my T a bit maybe? I'd be curious to try Briviact, just to see if it has any effect, as long as the side effects are mild. Keppra made me irritable for a while. My wife would call it Kepprage

 

[lapidus]

It's basically a really potent Keppra, from what I understand. A few of us here tried Keppra, some with success, others with horror stories. Keppra cured what H I had, which was pretty mild to begin with, and I think calmed my T a bit maybe? I'd be curious to try Briviact, just to see if it has any effect, as long as the side effects are mild. Keppra made me irritable for a while. My wife would call it Kepprage

"Keppra rage" is actually the "offical" term among people who use Keppra for epilepsy so she wasn't that far off

 

[swc5150]

"Keppra rage" is actually the "offical" term among people who use Keppra for epilepsy so she wasn't that far off

LOL, no kidding! It's true, that stuff would turn me into a monster sometimes.

 

[Vinnitus]

So, did anyone ultimately try this Brivaracetam?

 

[HomeoHebbian]

Here's what I don't get only 2 million people in the U.S, have epilepsy...Yet 50 million have tinnitus, so why nothing for tinnitus!? It's a bigger business yet nothing!? I honestly, don't get it. There's so many drugs for epilepsy, not even one for tinnitus!? I am so confused, honestly.

I share your frustration. Two reasons that I can see, Danny Boy: 1) There is no objective biomarker for tinnitus. Cancer : tumor, Epilepsy : seizure, tinnitus : ???. Without an objective biomarker we have no way of objectively estimating severity nor the means to gauge the efficacy of treatments; 2) Cancer biology is subsumed by the study of cellular biology. Epilepsy is the primary research focus of Neurology Departments. Tinnitus? It falls between the cracks of neuropsychiatry, neurology and otolaryngology. It takes a working knowledge of all three disciplines to understand it. No single discipline of medical sciences wants to own it.

I really believe that we will beat this thing. It is my career ambition to see that happen. I think real progress can only come from neuroscientists who are experts at understanding the nature of communication between the ear and the brain. There are a few qualified neuroscience labs who are devoting themselves to the study of tinnitus and tinnitus therapies. I wish there were a hundred laboratories but, sadly, there are less than a dozen that really understand the problem and have the means to make real progress. My laboratory is in a position to make progress and we are working hard to see that it happens.

 

[HomeoHebbian]

This is basically a more potent version of keppra, 10 times more potent. It works on the KV3.1 potassium channels, so is the same target as Autifony's new drug but is in phase 3 and been tested for 8 years already, so should be out sooner and could potentially help with tinnitus.

"Sudies conducted by Prof Len Kaczmarek's group at Yale University suggest that Autifony's Kv3 modulators may help to restore the timing of firing of neurons in the auditory brainstem important for central auditory processing."

http://www.ncbi.nlm.nih.gov/pubmed/17199019

http://www.zacks.com/stock/news/156795/ucb-reports-phase-iii-data-on-epilepsy-drug-to-file-in-2015

Can I be the wet blanket here and just point out that there is ZERO published connection between Kv3.1 and tinnitus? Nada. zip (at least that I know of). No clinical trial, no basic science. I understand that people are anxious but I don't really see how this news is relevant to tinnitus.

I lead some of the research studies on AUT3 for Autifony and I have collaborated and published with Kaczmarek, so I can speak with some authority here. There is a semi-plausible link to Kv3.1 and tinnitus in that >enhancing< electrical current through the Kv3.1 channel could, in theory, make the cell less excitable and be able to fire at higher rates. We have seen some encouraging findings in our lab with their compound, particularly as it relates to enhancing temporal processing (see Hidden Hearing Loss), but let's not put the cart before the horse. It's educational, interesting and informative to talk about drug therapies for tinnitus but unless I see findings from a double-blind, randomized, placebo-controlled clinical trial I don't want to get my own hopes up by thinking of therapeutic value.

...sorry. Wet blanket. Debbie Downer.

 

[undecided]

@HomeoHebbian brivaracetam does not work on KV3.1 channels. It binds to a protein that (hypothetically) reduces over-excited neurons. That's the official story (the company that produces the the drug claims this, at least).
Danny Boy once mentioned that it is a potassium channel modulator, it is not. This whole thread and its title is misleading.

 

[morticia]

This is basically a more potent version of keppra, 10 times more potent. It works on the KV3.1 potassium channels, so is the same target as Autifony's new drug but is in phase 3 and been tested for 8 years already, so should be out sooner and could potentially help with tinnitus.

"Sudies conducted by Prof Len Kaczmarek's group at Yale University suggest that Autifony's Kv3 modulators may help to restore the timing of firing of neurons in the auditory brainstem important for central auditory processing."

http://www.ncbi.nlm.nih.gov/pubmed/17199019

http://www.zacks.com/stock/news/156795/ucb-reports-phase-iii-data-on-epilepsy-drug-to-file-in-2015

This drug is now on the market. Have you actually been able to try it?

 

[morticia]

Can I be the wet blanket here and just point out that there is ZERO published connection between Kv3.1 and tinnitus? Nada. zip (at least that I know of). No clinical trial, no basic science. I understand that people are anxious but I don't really see how this news is relevant to tinnitus.

I lead some of the research studies on AUT3 for Autifony and I have collaborated and published with Kaczmarek, so I can speak with some authority here. There is a semi-plausible link to Kv3.1 and tinnitus in that >enhancing< electrical current through the Kv3.1 channel could, in theory, make the cell less excitable and be able to fire at higher rates. We have seen some encouraging findings in our lab with their compound, particularly as it relates to enhancing temporal processing (see Hidden Hearing Loss), but let's not put the cart before the horse. It's educational, interesting and informative to talk about drug therapies for tinnitus but unless I see findings from a double-blind, randomized, placebo-controlled clinical trial I don't want to get my own hopes up by thinking of therapeutic value.

...sorry. Wet blanket. Debbie Downer.

What were the results of the trial done with AUT00063? All I can find is a page stating that the trial was completed.

 

[bobthebuilder]

So, did anyone ultimately try this Brivaracetam?

Sorry to necropost... but seems like this is the official Brivaracetam thread. Haven't seen any actual reports of people trying it so though I would give my experience. Just got an Rx last week at 50mg 2x a day. Hasn't had any effect on my tinnitus, and just made me kind of dizzy/unbalanced/feeling mildly drunk. I don't have hyperacusis though, and never previously tried Keppra, so can't tell you if it would work for that or not.

 

[StoneInFocus]

[Brivaracetam - A Good Alternative in the Acute Treatment of Trigeminal Neuralgia] - PubMed

Brivaracetam - A Good Alternative in the Acute Treatment of Trigeminal Neuralgia <b>Abstract.</b> In trigeminal neuralgia there is brief neuropathic pain in the supply area of the trigeminal nerve. A distinction is made between classic, symptomatic, and idiopathic trigeminal neuralgia. Only a...

pubmed.ncbi.nlm.nih.gov

Anyone have access to this article?

 

[annV]

[Brivaracetam - A Good Alternative in the Acute Treatment of Trigeminal Neuralgia] - PubMed

Brivaracetam - A Good Alternative in the Acute Treatment of Trigeminal Neuralgia <b>Abstract.</b> In trigeminal neuralgia there is brief neuropathic pain in the supply area of the trigeminal nerve. A distinction is made between classic, symptomatic, and idiopathic trigeminal neuralgia. Only a...

pubmed.ncbi.nlm.nih.gov

Anyone have access to this article?

Who can you always trust?

Me.

 

[yeezysqueezy]

English translation of the above paper: