Brivaracetam — KV3.1 Modulator

[skoupidis]

Well, by the time it gets out, if it ever gets out, it may not even be for chronic sufferers...
Autifony shows more promise, but it still does not seem to be a permanent cure.
Perhaps a permanent cure doesn't come as a pill.

 

[Danny Boy]

Well, by the time it gets out, if it ever gets out, it may not even be for chronic sufferers...
Autifony shows more promise, but it still does not seem to be a permanent cure.
Perhaps a permanent cure doesn't come as a pill.

We don't know if Autifony's will be a permanent cure, but it seems quite safe to being on it long term seems like it'll be no problem.

 

[skoupidis]

We don't know if Autifony's will be a permanent cure, but it seems quite safe to being on it long term seems like it'll be no problem.

I would prefer it permanent. What is the meaning of the label for tinnitus and hearing loss? If it helps with hearing loss, it can not be only temporary, can it? I mean you take the pill and hear better for a couple of ours? The missing frequencies, the damaged cells/neurons/connections/whatever, reconnect, work, cure? But only for little time? What is that?

How exactly is a potassium channel drug supposed to work? RTG is not permanent. Does it help with hearing loss? Do missing frequencies come back? Can you enjoy music?
I cannot enjoy music the way I was before onset. My T interferes and I can specifically listen to mp3 being badly scrambled, like they are badly encoded or something. I mean a 320 kbps mp3 sounds like a 96 kbps. A 128 mp3 is so scrwed up I won't even listen to it... The sound is distorted somehow.

It was such a better world before...

 

[Danny Boy]

I would prefer it permanent. What is the meaning of the label for tinnitus and hearing loss? If it helps with hearing loss, it can not be only temporary, can it? I mean you take the pill and hear better for a couple of ours? The missing frequencies, the damaged cells/neurons/connections/whatever, reconnect, work, cure? But only for little time? What is that?

How exactly is a potassium channel drug supposed to work? RTG is not permanent. Does it help with hearing loss? Do missing frequencies come back? Can you enjoy music?
I cannot enjoy music the way I was before onset. My T interferes and I can specifically listen to mp3 being badly scrambled, like they are badly encoded or something. I mean a 320 kbps mp3 sounds like a 96 kbps. A 128 mp3 is so scrwed up I won't even listen to it... The sound is distorted somehow.

It was such a better world before...

Potassium channel modulators work by reducing the hyperactive neurons. So basically, they can reduce the excitability of these nerurons and Autifony's drug can repolarize the state of these neurons, effectively putting a break on the hyperactivity and restoring them to their normal state. They can't restore hearing, but can treat tinnitus. Hope that answers your question.

 

[skoupidis]

Potassium channel modulators work by reducing the hyperactive neurons. So basically, they can reduce the excitability of these nerurons and Autifony's drug can repolarize the state of these neurons, effectively putting a break on the hyperactivity and restoring them to their normal state. They can't restore hearing, but can treat tinnitus. Hope that answers your question.

Why do they call it for "Tinnitus and hearing loss" then?

 

[Silvio Sabo]

Why do they call it for "Tinnitus and hearing loss" then?

Probably becouse they tend to go together. Not always though.

But if the neurons are hyperactive then they don't work properly, which means that if they start working as they should you might get better hearing in a certain range of frequencies. Just a guess...

 

[Calories]

@Danny Boy , The two links posted does not suggest anything about tinnitus, will this work for Tinnitus?

 

[Barbara777]

Would this be for tinnitus, or would it be another drug we'd have to get off label and hard to get?

 

[Zechariah]

Would this be for tinnitus, or would it be another drug we'd have to get off label and hard to get?

Well, if you had used a minute or two to read source material you would have noticed that the drug is tested for treating epilepsy. So the answer is: Yes, it would be another possibly hard-to-get off label drug for tinnitus.

And btw, excellent finding @Danny Boy

 

[Barbara777]

Zechariah, you don't have to be sarcastic in your response. For your information I did take a minute or two to read it. I'm was wondering if there was more info I didn't know about.

 

[Zechariah]

Zechariah, you don't have to be sarcastic in your response. For your information I did take a minute or two to read it. I'm was wondering if there was more info I didn't know about.

Sorry, many people seem to be asking questions before actually reading any material or thread and the way you asked appeared to me as another question like this. I apologize my behavior.

 

[nills]

@Barbara777 If you add up information you can tell that this drug and also Autifony`s creation called AUT00063 work on the same potassium channels. Kv3.1 ... although this drug is n`t being tested for tinnitus it is safe to guess that if Autifony is on the right track ... this drug would probably do the same for tinnitus. I`m not sure what the difference is between the two and if the molecules are very different.

 

[Danny Boy]

@Barbara777 If you add up information you can tell that this drug and also Autifony`s creation called AUT00063 work on the same potassium channels. Kv3.1 ... although this drug is n`t being tested for tinnitus it is safe to guess that if Autifony is on the right track ... this drug would probably do the same for tinnitus. I`m not sure what the difference is between the two and if the molecules are very different.

Well, I'm just guessing that Autifony's drug is basically a more potent version of keppra and since this drug is 10x more potent than keppra, we've got an early t drug. God knows when Autifony's drug is gonna come out, we know this drug will be out this year or next.

 

[linearb]

We don't know if Autifony's will be a permanent cure, but it seems quite safe to being on it long term seems like it'll be no problem.

It does? Based on all the data that's available about how safe and effective it is when used for a period of years or decades?

Until there is longitudinal data from a large sample size over a period of decades, it's not really reasonable to make projections about how effective and/or toxic this drug is going to be. Drug metabolism is extremely complex, and serious adverse reactions that only show up in a minority of users often do not appear in the literature until well after a drug has been released -- even if it's a significant minority. Look at phen/fen.

I want this stuff to work as much as anyone else does, but I'm not going to get all excited about it until there's a reason to be, because I think it's pretty unlikely that any single drug is going to work really well for a huge percentage of T people without some significant side effects, and spending all my time wondering about whether some cure in the future is going to change my situation, just makes me spend more time thinking about T. If it works, great, but let's not let our hope get the better of our common sense.

 

[Danny Boy]

It does? Based on all the data that's available about how safe and effective it is when used for a period of years or decades?

Until there is longitudinal data from a large sample size over a period of decades, it's not really reasonable to make projections about how effective and/or toxic this drug is going to be. Drug metabolism is extremely complex, and serious adverse reactions that only show up in a minority of users often do not appear in the literature until well after a drug has been released -- even if it's a significant minority. Look at phen/fen.

I want this stuff to work as much as anyone else does, but I'm not going to get all excited about it until there's a reason to be, because I think it's pretty unlikely that any single drug is going to work really well for a huge percentage of T people without some significant side effects, and spending all my time wondering about whether some cure in the future is going to change my situation, just makes me spend more time thinking about T. If it works, great, but let's not let our hope get the better of our common sense.

Well, we'll know after phase 2, hope it's good news. The true cure will be the regeneration of hair cells.

 

[linearb]

Well, we'll know after phase 2, hope it's good news. The true cure will be the regeneration of hair cells.

I guess I'm just a skeptic at heart, but here's an interesting question:

If you have someone (like me), who has a small amount of upper-frequency hearing loss on one side. I now have well-established (5+ year) tinnitus which has become bilateral over time.

So, the tinnitus signal, is now deeply wrapped up in several parts of my brain. It started in the ear, but now the DCN, thalamus, and probably other structures are affected, as well.

What happens to the tinnitus if you go and fix the hearing loss by regenerating the hair cells?

I am very far from convinced that this will be enough to reverse the tinnitus. The problem isn't really the lack of input anymore, it's that clusters of cells have become hyperactive, and new firing patterns are now well established and being maintained.

 

[Danny Boy]

I guess I'm just a skeptic at heart, but here's an interesting question:

If you have someone (like me), who has a small amount of upper-frequency hearing loss on one side. I now have well-established (5+ year) tinnitus which has become bilateral over time.

So, the tinnitus signal, is now deeply wrapped up in several parts of my brain. It started in the ear, but now the DCN, thalamus, and probably other structures are affected, as well.

What happens to the tinnitus if you go and fix the hearing loss by regenerating the hair cells?

I am very far from convinced that this will be enough to reverse the tinnitus.

Yeah, if chickens somehow manage to rid themselves of t after the regeneration of their hair cells I don't see why we can't...So jealous of birds now lol

 

[linearb]

Yeah, if chickens somehow manage to rid themselves of t after the regeneration of their hair cells I don't see why we can't...So jealous of birds now lol

Even if it does work in humans (which is a huge if), realistically, the technology is at least 10-20 years from being ready for mass consumption by people with insignificant hearing loss (and that might be a very optimistic assessment).

If there's a cure for this solution in my lifetime, then I will benefit from that and be ecstatic about it. But, I'm not holding my breath.

 

[Danny Boy]

Even if it does work in humans (which is a huge if), realistically, the technology is at least 10-20 years from being ready for mass consumption by people with insignificant hearing loss (and that might be a very optimistic assessment).

If there's a cure for this solution in my lifetime, then I will benefit from that and be ecstatic about it. But, I'm not holding my breath.

Well, a massive reduction will be good enough for now. Mild tinnitus isn't so bad.

 

[linearb]

Well, a massive reduction will be good enough for now. Mild tinnitus isn't so bad.

out of curiousity, did you have any luck with benzos? They cut my ringing by about 90% for a loooong time, they kept working until I was most of the way off of them. Downsides turned out to not be worth it, but I still thought it was interesting that a lot of people report that benzos either do nothing or just make them calmer without actually changing the T. For me, it's like throwing a wet blanket over a light source, it totally covers it up.

 

[Danny Boy]

out of curiousity, did you have any luck with benzos? They cut my ringing by about 90% for a loooong time, they kept working until I was most of the way off of them. Downsides turned out to not be worth it, but I still thought it was interesting that a lot of people report that benzos either do nothing or just make them calmer without actually changing the T. For me, it's like throwing a wet blanket over a light source, it totally covers it up.

Well, I heard beznos can make it far worse.

 

[skoupidis]

Yeah, if chickens somehow manage to rid themselves of t after the regeneration of their hair cells I don't see why we can't...So jealous of birds now lol

Do you have a link of that? I mean they induced hearing loss to chickens, how do they know they got tinnitus and then got rid of it?
It is logical to assume such a thing. Temporary tinnitus (after a night club) goes on its own after one day or so. Inflammation of hair cells is what possibly causes this temporary damage. If these hair cells die, the tinnitus and damage remain for ever. This is the prevailing theory. That is why it is crucial to take corticosteroids immediately, to prevent the inflamed cells from dying by helping them recover.
This is the thoery on witch Novaris is based on and proceed with atoh1 trials. The part of Tinnittus being in the brain totally escapes me. Even if it happens after time, new neuron connections or hyperactivity because of hearing differentiation, it would be illogical to assume that they won't come back after hearing returns to normal. Even if it takes some time for the mind to do so, it is logical it will adjust ones again.

It is simply illogical to claim it will adjust to the destruction of hearing but it will not adjust to the recovering of hearing.

 

[Danny Boy]

Do you have a link of that? I mean they induced hearing loss to chickens, how do they know they got tinnitus and then got rid of it?
It is logical to assume such a thing. Temporary tinnitus (after a night club) goes on its own after one day or so. Inflammation of hair cells is what possibly causes this temporary damage. If these hair cells die, the tinnitus and damage remain for ever. This is the prevailing theory. That is why it is crucial to take corticosteroids immediately, to prevent the inflamed cells from dying by helping them recover.
This is the thoery on witch Novaris is based on and proceed with atoh1 trials. The part of Tinnittus being in the brain totally escapes me. Even if it happens after time, new neuron connections or hyperactivity because of hearing differentiation, it would be illogical to assume that they won't come back after hearing returns to normal. Even if it takes some time for the mind to do so, it is logical it will adjust ones again.

It is simply illogical to claim it will adjust to the destruction of hearing but it will not adjust to the recovering of hearing.

http://hearinghealthfoundation.org/curing_hearing_loss

 

[Christian78]

Do you have a link of that? I mean they induced hearing loss to chickens, how do they know they got tinnitus and then got rid of it?
It is logical to assume such a thing. Temporary tinnitus (after a night club) goes on its own after one day or so. Inflammation of hair cells is what possibly causes this temporary damage. If these hair cells die, the tinnitus and damage remain for ever. This is the prevailing theory. That is why it is crucial to take corticosteroids immediately, to prevent the inflamed cells from dying by helping them recover.
This is the thoery on witch Novaris is based on and proceed with atoh1 trials. The part of Tinnittus being in the brain totally escapes me. Even if it happens after time, new neuron connections or hyperactivity because of hearing differentiation, it would be illogical to assume that they won't come back after hearing returns to normal. Even if it takes some time for the mind to do so, it is logical it will adjust ones again.

It is simply illogical to claim it will adjust to the destruction of hearing but it will not adjust to the recovering of hearing.

is it not so that birds regenerate hearing?

 

[Christian78]

Well, a massive reduction will be good enough for now. Mild tinnitus isn't so bad.

Even if it does work in humans (which is a huge if), realistically, the technology is at least 10-20 years from being ready for mass consumption by people with insignificant hearing loss (and that might be a very optimistic assessment).

If there's a cure for this solution in my lifetime, then I will benefit from that and be ecstatic about it. But, I'm not holding my breath.

I agree, life time can be long, and they give you treatments, tinnitus is known that cut your life 50% because all stress no sleep, you just die of, and in last year when you don't even know for yourself you get something.

aldo about @Danny Boy his quote incurable is curable, well, i would rather say incurable is treatable because that raises chance 1000%

 

[Danny Boy]

is it not so that birds regenerate hearing?

Yeah, birds can regenerate hair-cells...They say within 10 years we'll be able to regenerate hair cells.

 

[linearb]

tinnitus is known that cut your life 50% because all stress no sleep, you just die of, and in last year when you don't even know for yourself you get something.

What? No, that's not true... I mean, extended sleep deprivation is bad for you, but lots of people sleep fine with tinnitus...

 

[Danny Boy]

What? No, that's not true... I mean, extended sleep deprivation is bad for you, but lots of people sleep fine with tinnitus...

Depends on how loud their tinnitus is...For example, before trobalt I needed meds to just sleep as it was so loud it would wake me up from sleep....Terrible, just terrible.

 

[Christian78]

What? No, that's not true... I mean, extended sleep deprivation is bad for you, but lots of people sleep fine with tinnitus...

a lot of people don have any problem with tinnitus, just those with severe that is some 3%

 

[dan]

a lot of people don have any problem with tinnitus, just those with severe that is some 3%

I agree, a lot of people who have T and are Ok with more or less, think they have severe tinnitus, when if fact they have mild/moderate tinnitus. T is so subjective and psychological and most people are not so tough psychologically (because of today's society) so do the math. If there was no such thing as truly severe (loud piercing unmaskable reactive multi tone T) then therapies such as CBT and TRT would be 99.9% effective, as opposed to only 80-85%.