Brivaracetam — KV3.1 Modulator

[Christian78]

btw MDMA trial begun, Daniel could read it if he was not banned on facebook:

18 hrs ·
MDMA trial update:
Day one yesterday of MDMA trial for managing Tinnitus. A Long day at the University for me, first up I took the pill, placebo or maybe the real thing, no one allowed to know, blood pressure checks half hourly, and then every 40 minutes, forms to fill in on level of T at that very moment , probably had to do that 5 times over 6 hours. I did get a bad headache and felt a bit light headed during the first hour, but considering I was soooo tired from only snatched bits of sleep in the week leading up to the first day of the trial, (that could be why) as no sleep meds allowed and none allowed from now on until 25th of April, that is to cover the 2nd day of the testing. No Alcohol from now until the 25th April either. They will let me no the results of the research later. NEXT update after April 20th Folks. Cheers Fran

 

[Danny Boy]

btw MDMA trial begun, Daniel could read it if he was not banned on facebook:

18 hrs ·
MDMA trial update:
Day one yesterday of MDMA trial for managing Tinnitus. A Long day at the University for me, first up I took the pill, placebo or maybe the real thing, no one allowed to know, blood pressure checks half hourly, and then every 40 minutes, forms to fill in on level of T at that very moment , probably had to do that 5 times over 6 hours. I did get a bad headache and felt a bit light headed during the first hour, but considering I was soooo tired from only snatched bits of sleep in the week leading up to the first day of the trial, (that could be why) as no sleep meds allowed and none allowed from now on until 25th of April, that is to cover the 2nd day of the testing. No Alcohol from now until the 25th April either. They will let me no the results of the research later. NEXT update after April 20th Folks. Cheers Fran

Can't you just buy MDMA?

 

[Christian78]

MDMA is part of ... drug so it is not ... well we will see

 

[Danny Boy]

By the way people! I found a document about KV3.1 modulates.

http://www.jneurosci.org/content/23/4/1133.full.pdf

 

[Carlos1]

By the way people! I found a document about KV3.1 modulates.

http://www.jneurosci.org/content/23/4/1133.full.pdf

Geez why hasn't there been anymore studies or trials using use Brivaracetam ?

 

[Danny Boy]

Geez why hasn't there been anymore studies or trials using use Brivaracetam ?

For tinnitus? Because nobody cares about us it seems...

 

[Carlos1]

For tinnitus? Because nobody cares about us it seems...

Yes for T ?.....That research dates back as far as 2003 ....Why bother do studies and then not proceed I don't get it

 

[Danny Boy]

Yes for T ?.....That research dates back as far as 2003 ....Why bother do studies and then not proceed I don't get it

Brivaracetam isn't for tinnitus, it's for epilepsy...But the possibility of it treating tinnitus is quite high.

 

[Carlos1]

Brivaracetam isn't for tinnitus, it's for epilepsy...But the possibility of it treating tinnitus is quite high.

That my point @Danny Boy you have all that data that can be applied to other diseases and yet nothing gets done...very disappointing

 

[Danny Boy]

That my point @Danny Boy you have all that data that can be applied to other diseases and yet nothing gets done...very disappointing

Well, maybe we can get it off-label.

And yeah, it is.

 

[Karl28]

How soon is soon

 

[Danny Boy]

How soon is soon

For brivaracetam? End of this year or next.

 

[Carlos1]

For brivaracetam? End of this year or next.

@Danny Boy How do you know that ? Was there a article that stated that?

 

[Danny Boy]

@Danny Boy How do you know that ? Was there a article that stated that?

Because they've applied for a licence in Europe and America.

 

[nills]

Belgian pharma company UCB has filed its investigational drug brivaracetam for approval to treat epilepsy in both the US and EU.

Both the US FDA and the European Medicines Agency (EMA) have accepted brivaracetam for review as an adjunctive therapy for the treatment of partial-onset seizures in [URL='http://www.pmlive.com/pharma_news/epilepsy_in_check_167369']epilepsy patients over 16 years of age.

Dr Iris Loew-Friedrich, chief medical officer and executive VP at UCB, commented: "Today is a major milestone for brivaracetam and an exciting day for everyone at UCB who is committed to its development.

"It is also an important time for the clinicians and patients whose involvement in brivaracetam clinical trials has been so important in helping up to address the need for new treatment options for adult patients who do not achieve partial-onset seizure control with current antiepileptic drugs."

The filings are supported by data from three phase III studies, which evaluated the efficacy and safety of adjunctive brivaracetam in a 5-200mg daily dosage in patients with uncontrolled partial-onset seizures.

A fourth phase III study evaluated the safety and tolerability of adjunctive brivaracetam given to patients with the same symptoms.

The filing is a major milestone for UCB as it pursues its goal of building its epilepsy business following the loss of patent for Keppra in the US and EU in the past few years.

The company has since turned to other drugs in its epilepsy portfolio, including Vimpat (lacosamide). At the end of last year UCB announced a partnership with Daiichi Sankyo to bring Vimpat to Japan.
[/URL]
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947

Apparently it is a Belgian pharmaceutical making this medicine ... In the best dream possible I will call them, talk to them, get it it off counter and be cured! ... than will book a flight to a deserted island and listen to the waves for immeasurable amount of time ... I will give them a call this week!

 

[Carlos1]

http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947

Apparently it is a Belgian pharmaceutical making this medicine ... In the best dream possible I will call them, talk to them, get it it off counter and be cured! ... than will book a flight to a deserted island and listen to the waves for immeasurable amount of time ... I will give them a call this week!

I wish you luck and silence @nills keep us posted

 

[Danny Boy]

Belgian pharma company UCB has filed its investigational drug brivaracetam for approval to treat epilepsy in both the US and EU.

Both the US FDA and the European Medicines Agency (EMA) have accepted brivaracetam for review as an adjunctive therapy for the treatment of partial-onset seizures in epilepsy patients over 16 years of age.

Dr Iris Loew-Friedrich, chief medical officer and executive VP at UCB, commented: "Today is a major milestone for brivaracetam and an exciting day for everyone at UCB who is committed to its development.

"It is also an important time for the clinicians and patients whose involvement in brivaracetam clinical trials has been so important in helping up to address the need for new treatment options for adult patients who do not achieve partial-onset seizure control with current antiepileptic drugs."

The filings are supported by data from three phase III studies, which evaluated the efficacy and safety of adjunctive brivaracetam in a 5-200mg daily dosage in patients with uncontrolled partial-onset seizures.

A fourth phase III study evaluated the safety and tolerability of adjunctive brivaracetam given to patients with the same symptoms.

The filing is a major milestone for UCB as it pursues its goal of building its epilepsy business following the loss of patent for Keppra in the US and EU in the past few years.

The company has since turned to other drugs in its epilepsy portfolio, including Vimpat (lacosamide). At the end of last year UCB announced a partnership with Daiichi Sankyo to bring Vimpat to Japan.
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947

Apparently it is a Belgian pharmaceutical making this medicine ... In the best dream possible I will call them, talk to them, get it it off counter and be cured! ... than will book a flight to a deserted island and listen to the waves for immeasurable amount of time ... I will give them a call this week!

Hope you can get it! Keep us posted about it.

 

[skoupidis]

Do they say what more this drug offers for epilepsy than other existent anticonvulsant drugs?

 

[Danny Boy]

Do they say what more this drug offers for epilepsy than other existent anticonvulsant drugs?

Basically, we're hoping this will be an early Autifony drug.

 

[Danny Boy]

Belgian pharma company UCB has filed its investigational drug brivaracetam for approval to treat epilepsy in both the US and EU.

Both the US FDA and the European Medicines Agency (EMA) have accepted brivaracetam for review as an adjunctive therapy for the treatment of partial-onset seizures in epilepsy patients over 16 years of age.

Dr Iris Loew-Friedrich, chief medical officer and executive VP at UCB, commented: "Today is a major milestone for brivaracetam and an exciting day for everyone at UCB who is committed to its development.

"It is also an important time for the clinicians and patients whose involvement in brivaracetam clinical trials has been so important in helping up to address the need for new treatment options for adult patients who do not achieve partial-onset seizure control with current antiepileptic drugs."

The filings are supported by data from three phase III studies, which evaluated the efficacy and safety of adjunctive brivaracetam in a 5-200mg daily dosage in patients with uncontrolled partial-onset seizures.

A fourth phase III study evaluated the safety and tolerability of adjunctive brivaracetam given to patients with the same symptoms.

The filing is a major milestone for UCB as it pursues its goal of building its epilepsy business following the loss of patent for Keppra in the US and EU in the past few years.

The company has since turned to other drugs in its epilepsy portfolio, including Vimpat (lacosamide). At the end of last year UCB announced a partnership with Daiichi Sankyo to bring Vimpat to Japan.
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947
http://www.pmlive.com/pharma_news/ucb_submits_brivaracetam_for_use_in_epilepsy_635947

Apparently it is a Belgian pharmaceutical making this medicine ... In the best dream possible I will call them, talk to them, get it it off counter and be cured! ... than will book a flight to a deserted island and listen to the waves for immeasurable amount of time ... I will give them a call this week!

Do you reckon it'll be out this year or next?

 

[valeri]

So is there any evidence that this drug may help tinnitus?

 

[nills]

INFO 1:

Brussels (BELGIUM), October 26, 2007 at 7:00 am CET - Phase III clinical trials of UCB's antiepileptic drug (AED) in development, brivaracetam , are underway, as adjunctive therapy in patients with refractory partial-onset epilepsy. Rikelta(TM) is the proposed tradename for brivaracetam . 25/10/07 22:10:00 | 2695

-------------------------------------------------------------------------------------------------------------------------------------------

INFO 2:

UCB announces first results from Phase III brivaracetam studies in epilepsy

• One study met its primary efficacy endpoint while the second study did not meet its primary efficacy endpoint
  
  
• A third safety and tolerability study confirmed brivaracetam was well tolerated
  
  
• Further analysis will be conducted and regulatory authorities will be consulted to determine next steps to bring brivaracetam to patients

Brussels (Belgium), 28 April 2009 - 07:00 am (CEST) - press release, regulated information - UCB announced today top-line results from two Phase III clinical studies to assess the efficacy and safety of brivaracetam as adjunctive treatment of partial-onset seizures in adults with epilepsy. Results were also announced for a third well-controlled safety and tolerability study.

SOURCE:
http://www.ucb.com/presscenter/News...om-Phase-III-brivaracetam-studies-in-epilepsy



reading this information I carefully conclude 2 things.

1. it takes YEARS for these drugs to come to the patients. They were speaking about phase 3 in 2007 and 2009. We are 6 years later.

2. The double blind controlled study started with milligrams in the range of nr`s like 5-50 ... I think the end nr was 200 mg daily. This makes me believe that Autifony also might start very low and therefor we have n`t yet heard of or maybe won`t hear of any positive effects soon. On the other hand it still gives hope that if they find the sweetspot it might be that AUT00063 is the drug we all been waiting for.

I sent UCB an email today and asked to speak to one of their people considering a few topics. I will keep you informed.

EDIT: Anyone have a good question I can ask please shoot ...

 

[valeri]

2007???

8 years ago and stil not on the market?

 

[Danny Boy]

2007???

8 years ago and stil not on the market?

Trials take an awfully long time...Which is why you better hope Autifony's drug get's fast-tracked or something.

 

[valeri]

Trials take an awfully long time...Which is why you better hope Autifony's drug get's fast-tracked or something.

All well and good but is there any evidence of this drug working for t?

 

[Danny Boy]

All well and good but is there any evidence of this drug working for t?

Not yeah, we'll found out later this year. I think most people got the placebo on here, sadly.

 

[valeri]

Not yeah, we'll found out later this year. I think most people got the placebo on here, sadly.

Danny I'm not talking autifony but brivaracetam.

 

[Danny Boy]

Danny I'm not talking autifony!

Oh, sorry. Of course there's no evidence it's not being made for tinnitus. But since it works on the same target as Autifony there's some potential it can off label, like trobalt. Hopefully, this will be a permeant reduction or cure.

 

[Carlos1]

Oh, sorry. Of course there's no evidence it's not being made for tinnitus. But since it works on the same target as Autifony there's some potential it can off label, like trobalt. Hopefully, this will be a permeant reduction or cure.

If brivaracetam is safer then Trobalt and easier to obtain then I too will try it

 

[undecided]

I'm not too optimistic about drug 'sequels' that promise to be X times more effective than previous ones.
I mean, look at trileptal and lyrica... They both promised better effectiveness and a safer side-effect profile yet doctors still prescribe tegretol and gabapentin by the ton.
Getting a new promising drug is good but we must wait for some actual 'real-life' results before doing anything with it. Drug companies will create hype for their products (i.e 10 times more effective) but that's what they usually do.